Macimorelin (AEZS-130)-Stimulated Growth Hormone (GH) Test: Validation of a Novel Oral Stimulation Test for the Diagnosis of Adult GH Deficiency

• Published in: The journal of clinical endocrinology and metabolism Vol. 98; no. 6; pp. 2422 - 2429
• Main Authors: Garcia, J. M., Swerdloff, R., Wang, C., Kyle, M., Kipnes, M., Biller, B. M. K., Cook, D., Yuen, K. C. J., Bonert, V., Dobs, A., Molitch, M. E., Merriam, G. R.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.06.2013; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Administration, Oral; Adult; Aged; Arginine; Biological and medical sciences; Body mass index; Cross-Over Studies; Diagnosis; EKG; Endocrine Care; Endocrinopathies; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Ghrelin; Ghrelin - analogs & derivatives; Growth Hormone-Releasing Hormone; Human Growth Hormone - blood; Human Growth Hormone - deficiency; Humans; Indoles; Insulin-like growth factor I; Insulin-Like Growth Factor I - analysis; Male; Medical sciences; Middle Aged; Obesity; ROC Curve; Tryptophan - analogs & derivatives; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Human; Endocrinopathy; Obesity; Nutrition; Deficiency; Nutrition disorder; Oral administration; Exploration; Metabolic diseases; Stimulation; Test validation; Somatotropin; Adenohypophyseal hormone; Adult; Diagnosis; Endocrinology; Nutritional status

Context:In the absence of panhypopituitarism and low serum IGF-I levels, the diagnosis of adult GH deficiency (AGHD) requires confirmation with a GH stimulation test. Macimorelin is a novel, orally active ghrelin mimetic that stimulates GH secretion.Objective:The objective of the study was to determ...