Pregnancy Alters CYP- and UGT-Mediated Metabolism of Buprenorphine

• Published in: Therapeutic drug monitoring Vol. 42; no. 2; p. 264
• Main Authors: Zhang, Hongfei, Bastian, Jaime R, Zhao, Wenchen, Chen, Huijun, Shaik, Imam H, Chaphekar, Nupur, Caritis, Steve N, Venkataramanan, Raman
• Format: Journal Article
• Language: English
• Published: United States 01.04.2020
• Subjects: Adult; Buprenorphine - analogs & derivatives; Buprenorphine - blood; Buprenorphine - pharmacokinetics; Cytochrome P-450 CYP3A - metabolism; Cytochrome P-450 Enzyme System - metabolism; Female; Glucuronosyltransferase - metabolism; Humans; Longitudinal Studies; Narcotic Antagonists - pharmacokinetics; Narcotic Antagonists - therapeutic use; Opiate Substitution Treatment - methods; Opioid-Related Disorders - drug therapy; Postpartum Period - metabolism; Pregnancy; Pregnancy Trimesters - metabolism; Young Adult

In the United States, drug addiction has become a nationwide health crisis. Recently, buprenorphine (BUP), a maintenance therapy approved by the Food and Drug Administration, has been increasingly used in pregnant women for the treatment of opioid use disorder. Pregnancy is associated with various a...