Effects of itraconazole and rifampicin on the single‐dose pharmacokinetics of the nonsteroidal mineralocorticoid receptor blocker esaxerenone in healthy Japanese subjects

• Published in: British journal of clinical pharmacology Vol. 86; no. 10; pp. 2070 - 2079
• Main Authors: Kirigaya, Yoshiaki, Shiramoto, Masanari, Ishizuka, Tomoko, Uchimaru, Hinako, Irie, Shin, Kato, Manabu, Shimizu, Takako, Nakatsu, Takafumi, Nishikawa, Yasuhiro, Ishizuka, Hitoshi
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.10.2020
• Subjects: CYP3A; drug–drug interactions; itraconazole; Original; pharmacokinetics; rifampicin; pharmacokinetics; CYP3A; rifampicin; drug-drug interactions; itraconazole

Aims To investigate the effects of the strong cytochrome P450 (CYP) 3A inhibitor itraconazole and the strong CYP3A inducer rifampicin on the pharmacokinetics of single‐dose esaxerenone, a nonsteroidal mineralocorticoid receptor blocker, in healthy Japanese subjects. Methods Two open‐label, single‐se...