Therapeutic drug monitoring of voriconazole for treatment and prophylaxis of invasive fungal infection in children

• Published in: British journal of clinical pharmacology Vol. 84; no. 1; pp. 197 - 203
• Main Authors: Allegra, Sarah, Fatiguso, Giovanna, De Francia, Silvia, Favata, Fabio, Pirro, Elisa, Carcieri, Chiara, De Nicolò, Amedeo, Cusato, Jessica, Di Perri, Giovanni, D'Avolio, Antonio
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.01.2018
• Subjects: Administration, Intravenous; Administration, Oral; Adolescent; Age Factors; Antifungal Agents - pharmacokinetics; Antifungal Agents - therapeutic use; antifungals; Biological Variation, Population; Child; Child, Preschool; Chromatography, High Pressure Liquid - instrumentation; Chromatography, High Pressure Liquid - methods; Creatinine - blood; Dose-Response Relationship, Drug; Drug Monitoring - instrumentation; Drug Monitoring - methods; Female; high‐performance liquid chromatography; Humans; invasive fungal infections; Invasive Fungal Infections - blood; Invasive Fungal Infections - therapy; Male; Mass Spectrometry - instrumentation; Mass Spectrometry - methods; Sex Factors; Short Report; therapeutic drug monitoring; triazoles; Voriconazole - pharmacokinetics; Voriconazole - therapeutic use; triazoles; high-performance liquid chromatography; antifungals; invasive fungal infections; therapeutic drug monitoring

Voriconazole therapeutic drug monitoring is not consistently recommended due to its high interpatient and intrapatient variability. Here, we aimed to describe our experience with voriconazole for treatment and prophylaxis of invasive fungal infections in paediatric patients. A fully validated high‐p...