Plasma p‐tau181, p‐tau217, and other blood‐based Alzheimer's disease biomarkers in a multi‐ethnic, community study

Introduction Blood‐based Alzheimer's disease (AD) biomarkers provide opportunities for community studies and across ethnic groups. We investigated blood biomarker concentrations in the Washington Heights‐Inwood Columbia Aging Project (WHICAP), a multi‐ethnic community study of aging and dementi...

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Published inAlzheimer's & dementia Vol. 17; no. 8; pp. 1353 - 1364
Main Authors Brickman, Adam M., Manly, Jennifer J., Honig, Lawrence S., Sanchez, Danurys, Reyes‐Dumeyer, Dolly, Lantigua, Rafael A., Lao, Patrick J., Stern, Yaakov, Vonsattel, Jean Paul, Teich, Andrew F., Airey, David C., Proctor, Nicholas Kyle, Dage, Jeffrey L., Mayeux, Richard
Format Journal Article
LanguageEnglish
Published United States John Wiley and Sons Inc 01.08.2021
Subjects
Aged, 80 and over
Alzheimer Disease - blood
Alzheimer Disease - diagnosis
Alzheimer Disease - ethnology
Alzheimer's disease
amyloid
Amyloid beta-Peptides - blood
Autopsy
Biomarkers - blood
blood‐based biomarkers
Ethnicity - statistics & numerical data
Female
Humans
Male
neurofilament light chain
Neurofilament Proteins - blood
New York City
Phosphorylation
Positron-Emission Tomography
tau
tau Proteins - blood
New York City
tau
amyloid
neurofilament light chain
blood-based biomarkers
Alzheimer's disease
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Abstract Introduction Blood‐based Alzheimer's disease (AD) biomarkers provide opportunities for community studies and across ethnic groups. We investigated blood biomarker concentrations in the Washington Heights‐Inwood Columbia Aging Project (WHICAP), a multi‐ethnic community study of aging and dementia. Methods We measured plasma amyloid beta (Aβ)40, Aβ42, total tau (t‐tau), phosphorylated tau (p‐tau)181, and p‐tau217, and neurofilament light chain (NfL) in 113 autopsied participants (29% with high AD neuropathological changes) and in 300 clinically evaluated individuals (42% with clinical AD). Receiver operating characteristics were used to evaluate each biomarker. We also investigated biomarkers as predictors of incident clinical AD. Results P‐tau181, p‐tau217, and NfL concentrations were elevated in pathologically and clinically diagnosed AD. Decreased Aβ42/Aβ40 ratio and increased p‐tau217 and p‐tau181 were associated with subsequent AD diagnosis. Discussion Blood‐based AD biomarker concentrations are associated with pathological and clinical diagnoses and can predict future development of clinical AD, providing evidence that they can be incorporated into multi‐ethnic, community‐based studies.
AbstractList Introduction Blood‐based Alzheimer's disease (AD) biomarkers provide opportunities for community studies and across ethnic groups. We investigated blood biomarker concentrations in the Washington Heights‐Inwood Columbia Aging Project (WHICAP), a multi‐ethnic community study of aging and dementia. Methods We measured plasma amyloid beta (Aβ)40, Aβ42, total tau (t‐tau), phosphorylated tau (p‐tau)181, and p‐tau217, and neurofilament light chain (NfL) in 113 autopsied participants (29% with high AD neuropathological changes) and in 300 clinically evaluated individuals (42% with clinical AD). Receiver operating characteristics were used to evaluate each biomarker. We also investigated biomarkers as predictors of incident clinical AD. Results P‐tau181, p‐tau217, and NfL concentrations were elevated in pathologically and clinically diagnosed AD. Decreased Aβ42/Aβ40 ratio and increased p‐tau217 and p‐tau181 were associated with subsequent AD diagnosis. Discussion Blood‐based AD biomarker concentrations are associated with pathological and clinical diagnoses and can predict future development of clinical AD, providing evidence that they can be incorporated into multi‐ethnic, community‐based studies.
Blood-based Alzheimer's disease (AD) biomarkers provide opportunities for community studies and across ethnic groups. We investigated blood biomarker concentrations in the Washington Heights-Inwood Columbia Aging Project (WHICAP), a multi-ethnic community study of aging and dementia.INTRODUCTIONBlood-based Alzheimer's disease (AD) biomarkers provide opportunities for community studies and across ethnic groups. We investigated blood biomarker concentrations in the Washington Heights-Inwood Columbia Aging Project (WHICAP), a multi-ethnic community study of aging and dementia.We measured plasma amyloid beta (Aβ)40, Aβ42, total tau (t-tau), phosphorylated tau (p-tau)181, and p-tau217, and neurofilament light chain (NfL) in 113 autopsied participants (29% with high AD neuropathological changes) and in 300 clinically evaluated individuals (42% with clinical AD). Receiver operating characteristics were used to evaluate each biomarker. We also investigated biomarkers as predictors of incident clinical AD.METHODSWe measured plasma amyloid beta (Aβ)40, Aβ42, total tau (t-tau), phosphorylated tau (p-tau)181, and p-tau217, and neurofilament light chain (NfL) in 113 autopsied participants (29% with high AD neuropathological changes) and in 300 clinically evaluated individuals (42% with clinical AD). Receiver operating characteristics were used to evaluate each biomarker. We also investigated biomarkers as predictors of incident clinical AD.P-tau181, p-tau217, and NfL concentrations were elevated in pathologically and clinically diagnosed AD. Decreased Aβ42/Aβ40 ratio and increased p-tau217 and p-tau181 were associated with subsequent AD diagnosis.RESULTSP-tau181, p-tau217, and NfL concentrations were elevated in pathologically and clinically diagnosed AD. Decreased Aβ42/Aβ40 ratio and increased p-tau217 and p-tau181 were associated with subsequent AD diagnosis.Blood-based AD biomarker concentrations are associated with pathological and clinical diagnoses and can predict future development of clinical AD, providing evidence that they can be incorporated into multi-ethnic, community-based studies.DISCUSSIONBlood-based AD biomarker concentrations are associated with pathological and clinical diagnoses and can predict future development of clinical AD, providing evidence that they can be incorporated into multi-ethnic, community-based studies.
Blood-based Alzheimer's disease (AD) biomarkers provide opportunities for community studies and across ethnic groups. We investigated blood biomarker concentrations in the Washington Heights-Inwood Columbia Aging Project (WHICAP), a multi-ethnic community study of aging and dementia. We measured plasma amyloid beta (Aβ)40, Aβ42, total tau (t-tau), phosphorylated tau (p-tau)181, and p-tau217, and neurofilament light chain (NfL) in 113 autopsied participants (29% with high AD neuropathological changes) and in 300 clinically evaluated individuals (42% with clinical AD). Receiver operating characteristics were used to evaluate each biomarker. We also investigated biomarkers as predictors of incident clinical AD. P-tau181, p-tau217, and NfL concentrations were elevated in pathologically and clinically diagnosed AD. Decreased Aβ42/Aβ40 ratio and increased p-tau217 and p-tau181 were associated with subsequent AD diagnosis. Blood-based AD biomarker concentrations are associated with pathological and clinical diagnoses and can predict future development of clinical AD, providing evidence that they can be incorporated into multi-ethnic, community-based studies.
Author Stern, Yaakov
Vonsattel, Jean Paul
Brickman, Adam M.
Airey, David C.
Reyes‐Dumeyer, Dolly
Manly, Jennifer J.
Honig, Lawrence S.
Lao, Patrick J.
Dage, Jeffrey L.
Mayeux, Richard
Lantigua, Rafael A.
Proctor, Nicholas Kyle
Sanchez, Danurys
Teich, Andrew F.
AuthorAffiliation 6 Eli Lilly and Company Indianapolis Indiana USA
1 Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University New York New York USA
3 Department of Neurology Vagelos College of Physicians and Surgeons, Columbia University New York Presbyterian Hospital New York New York USA
5 Department of Pathology and Cell Biology Vagelos College of Physicians and Surgeons, Columbia University New York New York USA
2 G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University New York New York USA
4 Department of Medicine Vagelos College of Physicians and Surgeons, Columbia University, New York Presbyterian Hospital New York New York USA
AuthorAffiliation_xml – name: 4 Department of Medicine Vagelos College of Physicians and Surgeons, Columbia University, New York Presbyterian Hospital New York New York USA
– name: 6 Eli Lilly and Company Indianapolis Indiana USA
– name: 2 G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University New York New York USA
– name: 1 Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University New York New York USA
– name: 5 Department of Pathology and Cell Biology Vagelos College of Physicians and Surgeons, Columbia University New York New York USA
– name: 3 Department of Neurology Vagelos College of Physicians and Surgeons, Columbia University New York Presbyterian Hospital New York New York USA
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  organization: New York Presbyterian Hospital
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33580742$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright 2021 The Authors. published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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Issue 8
Keywords tau
amyloid
neurofilament light chain
blood-based biomarkers
Alzheimer's disease
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2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
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Snippet Introduction Blood‐based Alzheimer's disease (AD) biomarkers provide opportunities for community studies and across ethnic groups. We investigated blood...
Blood-based Alzheimer's disease (AD) biomarkers provide opportunities for community studies and across ethnic groups. We investigated blood biomarker...
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SubjectTerms Aged, 80 and over
Alzheimer Disease - blood
Alzheimer Disease - diagnosis
Alzheimer Disease - ethnology
Alzheimer's disease
amyloid
Amyloid beta-Peptides - blood
Autopsy
Biomarkers - blood
blood‐based biomarkers
Ethnicity - statistics & numerical data
Female
Humans
Male
neurofilament light chain
Neurofilament Proteins - blood
New York City
Phosphorylation
Positron-Emission Tomography
tau
tau Proteins - blood
Title Plasma p‐tau181, p‐tau217, and other blood‐based Alzheimer's disease biomarkers in a multi‐ethnic, community study
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Falz.12301
https://www.ncbi.nlm.nih.gov/pubmed/33580742
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Volume 17
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