A TIME-COURSE CHARACTERIZATION OF MALE REPRODUCTIVE TOXICITY IN RATS TREATED WITH METHYL METHANESULPHONATE (MMS)

• Published in: Journal of toxicological sciences Vol. 30; no. 2; pp. 91 - 102
• Main Authors: KURIYAMA, Kazuya, YOKOI, Ryohei, KOBAYASHI, Kazuo, SUDA, Satoshi, HAYASHI, Morimichi, OZAWA, Shigenari, KURODA, Junji, TSUJII, Hirotada
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Toxicology 2005; Japan Science and Technology Agency
• Subjects: Animals; Body Weight - drug effects; Dominant lethal; Dose-Response Relationship, Drug; Epididymis - drug effects; Female; Male; Methyl Methanesulfonate - toxicity; MMS; Organ Size - drug effects; Rats; Rats, Sprague-Dawley; Reproductive toxicity; Sperm Count; Sperm morphology; Sperm Motility - drug effects; Spermatozoa - drug effects; Spermatozoa - pathology; Time-course study

Methyl methanesulphonate (MMS), a potent alkylating agent and testicular toxicant, was orally administered to rats for 5 days at doses of 20, 30, and 40 mg/kg. During the recovery period of 5 weeks, males were evaluated for multiple endpoints such as organ weights, fertility, and sperm parameters. T...