The JAK1 Inhibitor Upadacitinib Has No Effect on the Pharmacokinetics of Levonorgestrel and Ethinylestradiol: A Study in Healthy Female Subjects

• Published in: Journal of clinical pharmacology Vol. 59; no. 4; pp. 510 - 516
• Main Authors: Mohamed, Mohamed‐Eslam F., Trueman, Sheryl, Feng, Tian, Friedman, Alan, Othman, Ahmed A.
• Format: Journal Article
• Language: English
• Published: England 01.04.2019
• Subjects: ABT‐494; drug interaction; ethinylestradiol; levonorgestrel; upadacitinib; upadacitinib; ABT-494; drug interaction; levonorgestrel; ethinylestradiol

Upadacitinib is a novel selective oral Janus kinase 1 (JAK) inhibitor being developed for treatment of several inflammatory diseases. Oral contraceptives are anticipated to be a common concomitant medication in the target patient populations. This study was designed to evaluate the effect of multipl...