Redox- and Temperature-Controlled Drug Release from Hollow Mesoporous Silica Nanoparticles

• Published in: Chemistry : a European journal Vol. 19; no. 45; pp. 15410 - 15420
• Main Authors: Jiao, Yunfeng, Sun, Yangfei, Chang, Baisong, Lu, Daru, Yang, Wuli
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 04.11.2013; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Antineoplastic Agents - chemistry; antitumor agents; Carriers; Chemistry; core/shell materials; Disulfides; drug delivery; Drug Delivery Systems; Drugs; Glycols; Humans; Leakage; mesoporous materials; Nanoparticles; Nanoparticles - chemistry; Oxidation-Reduction; Silicon dioxide; Temperature; nanoparticles; drug delivery; core/shell materials; mesoporous materials; antitumor agents

A controlled drug‐delivery system has been developed based on mesoporous silica nanoparticles that deliver anticancer drugs into cancer cells with minimized side effects. The copolymer of two oligo(ethylene glycol) macromonomers cross‐linked by the disulfide linker N,N′‐bis(acryloyl)cystamine is use...