Bombesin improves adaptive immunity of the salivary gland during parenteral nutrition

• Published in: JPEN. Journal of parenteral and enteral nutrition Vol. 39; no. 2; p. 190
• Main Authors: Pierre, Joseph F, Heneghan, Aaron F, Wang, Xinying, Roenneburg, Drew A, Groblewski, Guy E, Kudsk, Kenneth A
• Format: Journal Article
• Language: English
• Published: United States 01.02.2015
• Subjects: Acinar Cells - drug effects; Adaptive Immunity - drug effects; Amylases - analysis; Animals; Bombesin - administration & dosage; Bombesin - pharmacology; Immunoglobulin A - analysis; Male; Mice; Mice, Inbred ICR; Neurotransmitter Agents - pharmacology; Parenteral Nutrition - methods; Plasma Cells - drug effects; Salivary Glands - drug effects; Salivary Glands - metabolism; T-Lymphocytes - drug effects; Treatment Outcome; salivary glands; parotid; parenteral nutrition; sIgA, amylase; submandibular

The parotid and submandibular salivary glands are gut-associated lymphoid tissues (GALTs) that secrete immune compounds into the oral cavity. Parenteral nutrition (PN) without enteral stimulation decreases GALT function, including intestinal lymphocyte counts and secretory immunoglobulin A (sIgA) le...