Polyphenol-rich foods exhibit DNA antioxidative properties and protect the glutathione system in healthy subjects

Scope Polyphenols (ingested via food items) can decrease DNA, and oxidative damage of proteins and lipids. However, polyphenol effects in healthy populations have not been well defined. The aim of this study was to assess the relationship between urinary total polyphenol excretion (TPE), a biomarker...

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Published inMolecular nutrition & food research Vol. 56; no. 7; pp. 1025 - 1033
Main Authors Pedret, Anna, Valls, Rosa M., Fernández-Castillejo, Sara, Catalán, Úrsula, Romeu, Marta, Giralt, Montserrat, Lamuela-Raventós, Rosa M., Medina-Remón, Alexander, Arija, Victoria, Aranda, Núria, Espinel, Alberto, Delgado, Marco Antonio, Solà, Rosa
Format Journal Article
LanguageEnglish
Published Weinheim Blackwell Publishing Ltd 01.07.2012
Wiley
Subjects
Adolescent
Adult
Age Factors
Aged
Antioxidants - administration & dosage
Antioxidants - analysis
Biological and medical sciences
Biomarkers - urine
Cross-Sectional Studies
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - urine
Diet
Diet Records
DNA Damage
DNA oxidation
Erythrocytes - metabolism
Female
Fermented food industries
Food Analysis
Food industries
Fruit and vegetable industries
Fruits
Fundamental and applied biological sciences. Psychology
Glutathione - blood
Humans
Male
Middle Aged
Oxidation-Reduction
Oxidative Stress
Polyphenols - administration & dosage
Polyphenols - analysis
Polyphenols - urine
Urinary phenol excretion
Vegetables
Vitaceae
Wine
Wines and vinegars
Young Adult
Wine
Excretion
Vegetables
Fruit
Healthy subject
Urinary phenol excretion
Antioxidant
Properties
DNA oxidation
Fruits
Alcoholic beverage
Phenol
Polyphenol
DNA
Phenols
Oxidation
Food
Glutathione
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Abstract Scope Polyphenols (ingested via food items) can decrease DNA, and oxidative damage of proteins and lipids. However, polyphenol effects in healthy populations have not been well defined. The aim of this study was to assess the relationship between urinary total polyphenol excretion (TPE), a biomarker of total polyphenol intake (TPI), polyphenol‐rich foods, and oxidative stress biomarkers in healthy adults of different ages participating in the cross‐sectional PAScual MEDicina study. Methods and results Urinary TPE was determined by Folin–Ciocalteau method in spot urine samples of 81 participants (46 women), classified into three age groups: 18 to 39, 40 to 54, and 55 to 72 years of age. TPI was quantified from 3‐day dietary records using the Phenol‐Explorer database. Urinary TPE increased with age (p < 0.001). Urinary TPE was inversely associated with urinary 8‐hydroxydeoxyguanosine (8‐OHdG; p<0.001) and erythrocyte‐oxidized glutathione concentrations (p < 0.05). A negative association between urinary 8‐OHdG and daily intake of polyphenols from vegetables and fermented beverages such as red wine was observed. Conclusion Urinary TPE increased with age and may reflect attenuation of oxidative damage. These results could explain the beneficial effects in healthy individuals of a diet rich in vegetables and moderate red wine; food items typical of the Mediterranean diet.
AbstractList Scope Polyphenols (ingested via food items) can decrease DNA , and oxidative damage of proteins and lipids. However, polyphenol effects in healthy populations have not been well defined. The aim of this study was to assess the relationship between urinary total polyphenol excretion ( TPE ), a biomarker of total polyphenol intake ( TPI ), polyphenol-rich foods, and oxidative stress biomarkers in healthy adults of different ages participating in the cross-sectional PAS cual MED icina study. Methods and results Urinary TPE was determined by F olin- C iocalteau method in spot urine samples of 81 participants (46 women), classified into three age groups: 18 to 39, 40 to 54, and 55 to 72 years of age. TPI was quantified from 3-day dietary records using the P henol- E xplorer database. Urinary TPE increased with age (p < 0.001). Urinary TPE was inversely associated with urinary 8-hydroxydeoxyguanosine (8- OH d G ; p<0.001) and erythrocyte-oxidized glutathione concentrations (p < 0.05). A negative association between urinary 8-OHdG and daily intake of polyphenols from vegetables and fermented beverages such as red wine was observed. Conclusion Urinary TPE increased with age and may reflect attenuation of oxidative damage. These results could explain the beneficial effects in healthy individuals of a diet rich in vegetables and moderate red wine; food items typical of the M editerranean diet.
Scope Polyphenols (ingested via food items) can decrease DNA, and oxidative damage of proteins and lipids. However, polyphenol effects in healthy populations have not been well defined. The aim of this study was to assess the relationship between urinary total polyphenol excretion (TPE), a biomarker of total polyphenol intake (TPI), polyphenol‐rich foods, and oxidative stress biomarkers in healthy adults of different ages participating in the cross‐sectional PAScual MEDicina study. Methods and results Urinary TPE was determined by Folin–Ciocalteau method in spot urine samples of 81 participants (46 women), classified into three age groups: 18 to 39, 40 to 54, and 55 to 72 years of age. TPI was quantified from 3‐day dietary records using the Phenol‐Explorer database. Urinary TPE increased with age (p < 0.001). Urinary TPE was inversely associated with urinary 8‐hydroxydeoxyguanosine (8‐OHdG; p<0.001) and erythrocyte‐oxidized glutathione concentrations (p < 0.05). A negative association between urinary 8‐OHdG and daily intake of polyphenols from vegetables and fermented beverages such as red wine was observed. Conclusion Urinary TPE increased with age and may reflect attenuation of oxidative damage. These results could explain the beneficial effects in healthy individuals of a diet rich in vegetables and moderate red wine; food items typical of the Mediterranean diet.
Polyphenols (ingested via food items) can decrease DNA, and oxidative damage of proteins and lipids. However, polyphenol effects in healthy populations have not been well defined. The aim of this study was to assess the relationship between urinary total polyphenol excretion (TPE), a biomarker of total polyphenol intake (TPI), polyphenol-rich foods, and oxidative stress biomarkers in healthy adults of different ages participating in the cross-sectional PAScual MEDicina study. Urinary TPE was determined by Folin-Ciocalteau method in spot urine samples of 81 participants (46 women), classified into three age groups: 18 to 39, 40 to 54, and 55 to 72 years of age. TPI was quantified from 3-day dietary records using the Phenol-Explorer database. Urinary TPE increased with age (p < 0.001). Urinary TPE was inversely associated with urinary 8-hydroxydeoxyguanosine (8-OHdG; p<0.001) and erythrocyte-oxidized glutathione concentrations (p < 0.05). A negative association between urinary 8-OHdG and daily intake of polyphenols from vegetables and fermented beverages such as red wine was observed. Urinary TPE increased with age and may reflect attenuation of oxidative damage. These results could explain the beneficial effects in healthy individuals of a diet rich in vegetables and moderate red wine; food items typical of the Mediterranean diet.
Polyphenols (ingested via food items) can decrease DNA, and oxidative damage of proteins and lipids. However, polyphenol effects in healthy populations have not been well defined. The aim of this study was to assess the relationship between urinary total polyphenol excretion (TPE), a biomarker of total polyphenol intake (TPI), polyphenol-rich foods, and oxidative stress biomarkers in healthy adults of different ages participating in the cross-sectional PAScual MEDicina study.SCOPEPolyphenols (ingested via food items) can decrease DNA, and oxidative damage of proteins and lipids. However, polyphenol effects in healthy populations have not been well defined. The aim of this study was to assess the relationship between urinary total polyphenol excretion (TPE), a biomarker of total polyphenol intake (TPI), polyphenol-rich foods, and oxidative stress biomarkers in healthy adults of different ages participating in the cross-sectional PAScual MEDicina study.Urinary TPE was determined by Folin-Ciocalteau method in spot urine samples of 81 participants (46 women), classified into three age groups: 18 to 39, 40 to 54, and 55 to 72 years of age. TPI was quantified from 3-day dietary records using the Phenol-Explorer database. Urinary TPE increased with age (p < 0.001). Urinary TPE was inversely associated with urinary 8-hydroxydeoxyguanosine (8-OHdG; p<0.001) and erythrocyte-oxidized glutathione concentrations (p < 0.05). A negative association between urinary 8-OHdG and daily intake of polyphenols from vegetables and fermented beverages such as red wine was observed.METHODS AND RESULTSUrinary TPE was determined by Folin-Ciocalteau method in spot urine samples of 81 participants (46 women), classified into three age groups: 18 to 39, 40 to 54, and 55 to 72 years of age. TPI was quantified from 3-day dietary records using the Phenol-Explorer database. Urinary TPE increased with age (p < 0.001). Urinary TPE was inversely associated with urinary 8-hydroxydeoxyguanosine (8-OHdG; p<0.001) and erythrocyte-oxidized glutathione concentrations (p < 0.05). A negative association between urinary 8-OHdG and daily intake of polyphenols from vegetables and fermented beverages such as red wine was observed.Urinary TPE increased with age and may reflect attenuation of oxidative damage. These results could explain the beneficial effects in healthy individuals of a diet rich in vegetables and moderate red wine; food items typical of the Mediterranean diet.CONCLUSIONUrinary TPE increased with age and may reflect attenuation of oxidative damage. These results could explain the beneficial effects in healthy individuals of a diet rich in vegetables and moderate red wine; food items typical of the Mediterranean diet.
Author Romeu, Marta
Aranda, Núria
Solà, Rosa
Fernández-Castillejo, Sara
Espinel, Alberto
Pedret, Anna
Lamuela-Raventós, Rosa M.
Medina-Remón, Alexander
Arija, Victoria
Giralt, Montserrat
Delgado, Marco Antonio
Catalán, Úrsula
Valls, Rosa M.
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Issue 7
Keywords Wine
Excretion
Vegetables
Fruit
Healthy subject
Urinary phenol excretion
Antioxidant
Properties
DNA oxidation
Fruits
Alcoholic beverage
Phenol
Polyphenol
DNA
Phenols
Oxidation
Food
Glutathione
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Covas, M. I., Gambert, P., Fitó, M., de la Torre, R., Wine and oxidative stress: up-to-date evidence of the effects of moderate wine consumption on oxidative damage in humans. Atherosclerosis 2010, 208, 297-304.
Elousa, R., Marrugat, J., Molina, L., Pons, S., et al., Validation of the Minnesota Leisure Time Physical Activity Questionnaire in Spanish men. The MARATHOM investigators. Am. J. Epidemiol. 1994, 139, 1197-1209.
Cao, G., Alessio, H. M., Cutler, R. G., Oxygen-radical absorbance capacity assay for antioxidants. Free Radic. Biol. Med. 1993, 14, 303-311.
Misra, H. P., Fridovich, I., Superoxide dismutase and peroxidase: a positive activity stain applicable to polyacrylamide gel electropherograms. Arch. Biochem. Biophys. 1977, 183, 511-515.
Wheeler, C. R., Salzman, J. A., Elsayed, N. M., Omaye, S. T., et al., Automated assays for superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Anal. Biochem. 1990, 184, 193-199.
Benzie, I. F. F., Strain, J. J., The ferric reducing ability of plasma (FRAP) as a measure of ''Antioxidant Power'': the FRAP Assay. Anal. Biochem. 1996, 239, 70-76.
Medina-Remón, A., Zamora-Ros, R., Rotchés-Ribalta, M., Andres-Lacueva, C., et al., Total polyphenol excretion and blood pressure in subjects at high cardiovascular risk. Nutr. Metab. Cardiovasc. Dis. 2011, 21, 323-331.
Cohen, G., Dembiec, D., Marcus, J., Measurement of catalase activity in tissue extracts. Anal. Biochem. 1970, 34, 30-38.
Tamura, S., Tsukahara, H., Masaki, U., Maeda, M., et al., Evaluation of a urinary multi-parameter biomarker set for oxidative stress in children, adolescents and young adults. Free Radic. Res. 2006, 40, 1198-1205.
Valavanidis, A., Vlachogianni, T., Fiotakis, C., 8-hydroxy-2'deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J. Environ. Sci. Health C. Environ. Carcinog. Ecotoxicol. Rev. 2009, 27, 120-139.
Stevenson, D. E., Hurst, R. D., Polyphenolic phytochemicals- just antioxidants or much more? Cell. Mol. Life Sci. 2007, 64, 2900-2916.
Jaffé, M., Über den Niederschlag welchen Pikrinsäure in normalem Harn erzeugt und über eine neue Reaktion des Kreatinins. Physiol. Chem. 1886, 10, 391-400.
Hissin, P. J., Hilf, R., A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 1976, 74, 214-226.
Arola-Arnal, A., Bladé, C., Proanthocyanidins modulate MicroRNA expression in Human HepG2 Cells. PLoS ONE 2011, 6, e25982, DOI: 10.1371/journal.pone.0025982.
Saura-Calixto, F., Goni, I., Antioxidant capacity of the Spanish Mediterranean diet. Food Chem. 2006, 94, 442-447.
Uriquiaga, I., Strobe, P., Perez, D., Martinez, C., et al., Mediterranean diet and red wine protect against oxidative damage in young volunteers. Atherosclerosis 2010, 211, 694-699.
Ya-Chen, Y., Chong-Kuei, L., Ai-Husan, L., Yu-Wen, Y., Induction of glutathione synthesis and heme oxygenase 1 by flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress. Free Radic. Biol. Med. 2011, 51, 2073-2081.
Bouayed, J., Bohn, T., Exogenous antioxidants-double-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxid. Med. Cell Longev. 2010, 3, 228-237.
Spencer, J. P., Abd El Mohsen, M. M., Minihane, A. M., Mathers, J. C., Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research. Br. J. Nutr. 2008, 99, 12-22.
Kemperman, R. A., Bolca, S., Roger, L. C., Vaughan, E., Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities. Microbiology 2010, 156, 3224-3231.
Chen, C. M., Lin, Y. L., Chen, C. Y., Hsu, C. Y., et al., Consumption of purple sweet potato leaves decreases lipid peroxidation and DNA damage in humans. Asia Pac. J. Clin. Nutr. 2008, 17, 408-414.
Wang, D., Luo, X., Zhong, Y., Yang, W., et al., Pu-erh tea extract supplementation attenuates the oxidative DNA damage and oxidative stress in Sprague-Dawley rats with renal dysfunction induced by subchronic 3-methyl-2-quinoxalin benzenevinylketo-1,4-dioxide exposure. Food Chem. Toxicol. 2011, 50, 147-154.
Seifried, H. E., Anderson, D. E., Fisher, E. I., Milner, J. A., A review of the interaction among dietary antioxidants and reactive oxygen species. J. Nutr. Biochem. 2007, 18, 567-579.
Terra, X., Valls, J., Vitrac, X., Mérrillon, J. M., Grape-seed procyanidins act as antiinflamatory agents in endotoxin-stimulated RAW 264.7 macrophages by inhibiting NFkB signalling pathway. J. Agric. Food Chem. 2007, 55, 4357-4365.
EFSA Panel on Dietetic Products NaANScientific Opinion on the substantiation of health claims related to various food(s)/food constituent(s) and protection of cells from premature aging, antioxidant activity, antioxidant content and antioxidant properties, and protection of DNA, proteins and lipids from oxidative damage pursuant to Article 13(1) of Regulation (EC) No 1924/2006). EFSA J. 2010, 8, 1489-1552.
Speciale, A., Canali, R., Chirafisi, J., Saija, A., et al., Cyanidin-3-O-glucoside protection against TNF-α-induced endothelial dysfunction: involvement of nuclear factor-kB signalling. J. Agric. Food Chem. 2010, 58, 12048-12054.
Buege, J. A., Aust, S. D., Microsomal lipid peroxidation. Methods Enzymol. 1978, 52, 302-310.
Cooke, M. S., Evans, M. D., Dizdaroglu, M., Lunec, J., Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J. 2003, 17, 1195-1214.
Tsimikas, S., Oxidative biomarkers in the diagnosis and prognosis of cardiovascular diseases. Am. J. Cardiol. 2006, 98, S9-S17.
Yin, B., Whyatt, R. M., Perera, F. P., Randall, M. C., et al., Determination of 8-hydroxydeoxyguanosine by an immunoaffinity chromatography-monoclonal antibody-based ELISA. Free Radic. Biol. Med. 1995, 18, 1023-1032.
Engelfried, P., Hoekstra, J., Hoogeneveen, R., Büchner, F., et al., Food and vessels: the importance of a healthy diet to prevent cardiovascular disease. Eur. J. Cardiov. Prev. Rehabil. 2010, 17, 50-55.
Medina-Remón, A., Barrionuevo-Gonzáles, A., Zamora-Ros, R., Andres-Lacueva, C., et al., Rapid Folin-Ciocalteau method using microtiter 96-well plate cartridge for solid phase extraction to assess urinary total phenolic compounds, as a biomarker of total polyphenol intake. Anal. Chim. Acta. 2009, 634, 54-60.
Roura, E., Andrés-Lacueva, C., Estruch, R., Lamuela-Raventós, R. M., Total polyphenol intake stimulated by a modified Folin-Ciocalteau assay of urine. Clin. Chem. 2006, 52, 749-752.
2007; 18
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References_xml – reference: EFSA Panel on Dietetic Products NaANScientific Opinion on the substantiation of health claims related to various food(s)/food constituent(s) and protection of cells from premature aging, antioxidant activity, antioxidant content and antioxidant properties, and protection of DNA, proteins and lipids from oxidative damage pursuant to Article 13(1) of Regulation (EC) No 1924/2006). EFSA J. 2010, 8, 1489-1552.
– reference: Roura, E., Andrés-Lacueva, C., Estruch, R., Lamuela-Raventós, R. M., Total polyphenol intake stimulated by a modified Folin-Ciocalteau assay of urine. Clin. Chem. 2006, 52, 749-752.
– reference: Hissin, P. J., Hilf, R., A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 1976, 74, 214-226.
– reference: Saura-Calixto, F., Goni, I., Antioxidant capacity of the Spanish Mediterranean diet. Food Chem. 2006, 94, 442-447.
– reference: Arola-Arnal, A., Bladé, C., Proanthocyanidins modulate MicroRNA expression in Human HepG2 Cells. PLoS ONE 2011, 6, e25982, DOI: 10.1371/journal.pone.0025982.
– reference: Speciale, A., Canali, R., Chirafisi, J., Saija, A., et al., Cyanidin-3-O-glucoside protection against TNF-α-induced endothelial dysfunction: involvement of nuclear factor-kB signalling. J. Agric. Food Chem. 2010, 58, 12048-12054.
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– reference: Stevenson, D. E., Hurst, R. D., Polyphenolic phytochemicals- just antioxidants or much more? Cell. Mol. Life Sci. 2007, 64, 2900-2916.
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Snippet Scope Polyphenols (ingested via food items) can decrease DNA, and oxidative damage of proteins and lipids. However, polyphenol effects in healthy populations...
Polyphenols (ingested via food items) can decrease DNA, and oxidative damage of proteins and lipids. However, polyphenol effects in healthy populations have...
Scope Polyphenols (ingested via food items) can decrease DNA , and oxidative damage of proteins and lipids. However, polyphenol effects in healthy populations...
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SubjectTerms Adolescent
Adult
Age Factors
Aged
Antioxidants - administration & dosage
Antioxidants - analysis
Biological and medical sciences
Biomarkers - urine
Cross-Sectional Studies
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - urine
Diet
Diet Records
DNA Damage
DNA oxidation
Erythrocytes - metabolism
Female
Fermented food industries
Food Analysis
Food industries
Fruit and vegetable industries
Fruits
Fundamental and applied biological sciences. Psychology
Glutathione - blood
Humans
Male
Middle Aged
Oxidation-Reduction
Oxidative Stress
Polyphenols - administration & dosage
Polyphenols - analysis
Polyphenols - urine
Urinary phenol excretion
Vegetables
Vitaceae
Wine
Wines and vinegars
Young Adult
Title Polyphenol-rich foods exhibit DNA antioxidative properties and protect the glutathione system in healthy subjects
URI https://api.istex.fr/ark:/67375/WNG-P5ZLD34H-X/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmnfr.201100676
https://www.ncbi.nlm.nih.gov/pubmed/22760977
https://www.proquest.com/docview/1023533851
https://www.proquest.com/docview/1439219525
Volume 56
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