Levels and function of regulatory T cells in patients with polymorphic light eruption: relation to photohardening
Summary Background We hypothesized that regulatory T cells (Tregs) are involved in the immunological abnormalities seen in patients with polymorphic light eruption (PLE). Objectives To investigate the number and suppressive function of peripheral Tregs in patients with PLE compared with healthy cont...
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Published in | British journal of dermatology (1951) Vol. 173; no. 2; pp. 519 - 526 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.08.2015
Oxford University Press John Wiley and Sons Inc |
Subjects | |
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Abstract | Summary
Background
We hypothesized that regulatory T cells (Tregs) are involved in the immunological abnormalities seen in patients with polymorphic light eruption (PLE).
Objectives
To investigate the number and suppressive function of peripheral Tregs in patients with PLE compared with healthy controls.
Methods
Blood sampling was done in 30 patients with PLE [seeking or not seeking 311‐nm ultraviolet (UV)B photohardening] as well as 19 healthy controls at two time points: TP1, March to June (before phototherapy); and TP2, May to August (after phototherapy). We compared the number of CD4+CD25highCD127−FoxP3+ Tregs by flow cytometry and their function by assessing FoxP3 mRNA levels and effector T cell/Treg suppression assays.
Results
Tregs isolated from healthy controls significantly suppressed the proliferation of effector T cells at TP1 by 68% (P = 0·0156). In contrast, Tregs from patients with PLE entirely lacked the capacity to suppress effector T‐cell proliferation at that time point. The medical photohardening seen in 23 patients with PLE resulted in a significant increase in the median percentage of circulating Tregs [both as a proportion of all lymphocytes; 65 6% increase (P = 0·0049), and as a proportion of CD4+ T cells; 32.5% increase (P = 0·0049)]. This was accompanied by an increase in the expression of FoxP3 mRNA (P = 0·0083) and relative immunosuppressive function of Tregs (P = 0·083) comparing the two time points in representative subsets of patients with healthy controls tested. Seven patients with PLE not receiving 311‐nm UVB also exhibited an increase in the number of Tregs but this was not statistically significant. No significant differences in Treg numbers were observed in healthy subjects between the two time points.
Conclusions
An impaired Treg function is likely to play a role in PLE pathogenesis. A UV‐induced increase in the number of Tregs (either naturally or therapeutically) may be a compensatory mechanism by which the immune system counteracts the susceptibility to PLE.
What's already known about this topic?
Patients with polymorphic light eruption (PLE) display immunological abnormalities.
Previous studies have shown that they are resistant to the immune suppressive effects of sunlight.
What does this study add?
We found that the number and suppressive function of regulatory T cells (Tregs) are crucial in the pathogenesis of PLE.
An increase in Treg levels (after photohardening) might be a compensatory mechanism by which the immune system intends to counteract the susceptibility to PLE formation. |
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AbstractList | We hypothesized that regulatory T cells (Tregs) are involved in the immunological abnormalities seen in patients with polymorphic light eruption (PLE).
To investigate the number and suppressive function of peripheral Tregs in patients with PLE compared with healthy controls.
Blood sampling was done in 30 patients with PLE [seeking or not seeking 311-nm ultraviolet (UV)B photohardening] as well as 19 healthy controls at two time points: TP1, March to June (before phototherapy); and TP2, May to August (after phototherapy). We compared the number of CD4(+) CD25(high) CD127(-) FoxP3(+) Tregs by flow cytometry and their function by assessing FoxP3 mRNA levels and effector T cell/Treg suppression assays.
Tregs isolated from healthy controls significantly suppressed the proliferation of effector T cells at TP1 by 68% (P = 0·0156). In contrast, Tregs from patients with PLE entirely lacked the capacity to suppress effector T-cell proliferation at that time point. The medical photohardening seen in 23 patients with PLE resulted in a significant increase in the median percentage of circulating Tregs [both as a proportion of all lymphocytes; 65 6% increase (P = 0·0049), and as a proportion of CD4(+) T cells; 32.5% increase (P = 0·0049)]. This was accompanied by an increase in the expression of FoxP3 mRNA (P = 0·0083) and relative immunosuppressive function of Tregs (P = 0·083) comparing the two time points in representative subsets of patients with healthy controls tested. Seven patients with PLE not receiving 311-nm UVB also exhibited an increase in the number of Tregs but this was not statistically significant. No significant differences in Treg numbers were observed in healthy subjects between the two time points.
An impaired Treg function is likely to play a role in PLE pathogenesis. A UV-induced increase in the number of Tregs (either naturally or therapeutically) may be a compensatory mechanism by which the immune system counteracts the susceptibility to PLE. Summary Background We hypothesized that regulatory T cells (Tregs) are involved in the immunological abnormalities seen in patients with polymorphic light eruption (PLE). Objectives To investigate the number and suppressive function of peripheral Tregs in patients with PLE compared with healthy controls. Methods Blood sampling was done in 30 patients with PLE [seeking or not seeking 311‐nm ultraviolet (UV)B photohardening] as well as 19 healthy controls at two time points: TP1, March to June (before phototherapy); and TP2, May to August (after phototherapy). We compared the number of CD4+CD25highCD127−FoxP3+ Tregs by flow cytometry and their function by assessing FoxP3 mRNA levels and effector T cell/Treg suppression assays. Results Tregs isolated from healthy controls significantly suppressed the proliferation of effector T cells at TP1 by 68% (P = 0·0156). In contrast, Tregs from patients with PLE entirely lacked the capacity to suppress effector T‐cell proliferation at that time point. The medical photohardening seen in 23 patients with PLE resulted in a significant increase in the median percentage of circulating Tregs [both as a proportion of all lymphocytes; 65 6% increase (P = 0·0049), and as a proportion of CD4+ T cells; 32.5% increase (P = 0·0049)]. This was accompanied by an increase in the expression of FoxP3 mRNA (P = 0·0083) and relative immunosuppressive function of Tregs (P = 0·083) comparing the two time points in representative subsets of patients with healthy controls tested. Seven patients with PLE not receiving 311‐nm UVB also exhibited an increase in the number of Tregs but this was not statistically significant. No significant differences in Treg numbers were observed in healthy subjects between the two time points. Conclusions An impaired Treg function is likely to play a role in PLE pathogenesis. A UV‐induced increase in the number of Tregs (either naturally or therapeutically) may be a compensatory mechanism by which the immune system counteracts the susceptibility to PLE. What's already known about this topic? Patients with polymorphic light eruption (PLE) display immunological abnormalities. Previous studies have shown that they are resistant to the immune suppressive effects of sunlight. What does this study add? We found that the number and suppressive function of regulatory T cells (Tregs) are crucial in the pathogenesis of PLE. An increase in Treg levels (after photohardening) might be a compensatory mechanism by which the immune system intends to counteract the susceptibility to PLE formation. BackgroundWe hypothesized that regulatory T cells (Tregs) are involved in the immunological abnormalities seen in patients with polymorphic light eruption (PLE).ObjectivesTo investigate the number and suppressive function of peripheral Tregs in patients with PLE compared with healthy controls.MethodsBlood sampling was done in 30 patients with PLE [seeking or not seeking 311‐nm ultraviolet (UV)B photohardening] as well as 19 healthy controls at two time points: TP1, March to June (before phototherapy); and TP2, May to August (after phototherapy). We compared the number of CD4+CD25highCD127−FoxP3+ Tregs by flow cytometry and their function by assessing FoxP3 mRNA levels and effector T cell/Treg suppression assays.ResultsTregs isolated from healthy controls significantly suppressed the proliferation of effector T cells at TP1 by 68% (P = 0·0156). In contrast, Tregs from patients with PLE entirely lacked the capacity to suppress effector T‐cell proliferation at that time point. The medical photohardening seen in 23 patients with PLE resulted in a significant increase in the median percentage of circulating Tregs [both as a proportion of all lymphocytes; 65 6% increase (P = 0·0049), and as a proportion of CD4+ T cells; 32.5% increase (P = 0·0049)]. This was accompanied by an increase in the expression of FoxP3 mRNA (P = 0·0083) and relative immunosuppressive function of Tregs (P = 0·083) comparing the two time points in representative subsets of patients with healthy controls tested. Seven patients with PLE not receiving 311‐nm UVB also exhibited an increase in the number of Tregs but this was not statistically significant. No significant differences in Treg numbers were observed in healthy subjects between the two time points.ConclusionsAn impaired Treg function is likely to play a role in PLE pathogenesis. A UV‐induced increase in the number of Tregs (either naturally or therapeutically) may be a compensatory mechanism by which the immune system counteracts the susceptibility to PLE. BACKGROUNDWe hypothesized that regulatory T cells (Tregs) are involved in the immunological abnormalities seen in patients with polymorphic light eruption (PLE). OBJECTIVESTo investigate the number and suppressive function of peripheral Tregs in patients with PLE compared with healthy controls. METHODSBlood sampling was done in 30 patients with PLE [seeking or not seeking 311-nm ultraviolet (UV)B photohardening] as well as 19 healthy controls at two time points: TP1, March to June (before phototherapy); and TP2, May to August (after phototherapy). We compared the number of CD4(+) CD25(high) CD127(-) FoxP3(+) Tregs by flow cytometry and their function by assessing FoxP3 mRNA levels and effector T cell/Treg suppression assays. RESULTSTregs isolated from healthy controls significantly suppressed the proliferation of effector T cells at TP1 by 68% (P = 0·0156). In contrast, Tregs from patients with PLE entirely lacked the capacity to suppress effector T-cell proliferation at that time point. The medical photohardening seen in 23 patients with PLE resulted in a significant increase in the median percentage of circulating Tregs [both as a proportion of all lymphocytes; 65 6% increase (P = 0·0049), and as a proportion of CD4(+) T cells; 32.5% increase (P = 0·0049)]. This was accompanied by an increase in the expression of FoxP3 mRNA (P = 0·0083) and relative immunosuppressive function of Tregs (P = 0·083) comparing the two time points in representative subsets of patients with healthy controls tested. Seven patients with PLE not receiving 311-nm UVB also exhibited an increase in the number of Tregs but this was not statistically significant. No significant differences in Treg numbers were observed in healthy subjects between the two time points. CONCLUSIONSAn impaired Treg function is likely to play a role in PLE pathogenesis. A UV-induced increase in the number of Tregs (either naturally or therapeutically) may be a compensatory mechanism by which the immune system counteracts the susceptibility to PLE. What's already known about this topic? Patients with polymorphic light eruption (PLE) display immunological abnormalities. Previous studies have shown that they are resistant to the immune suppressive effects of sunlight. What does this study add? We found that the number and suppressive function of regulatory T cells (Tregs) are crucial in the pathogenesis of PLE. An increase in Treg levels (after photohardening) might be a compensatory mechanism by which the immune system intends to counteract the susceptibility to PLE formation. |
Author | Reginato, E. Bambach, I. Wolf, P. Schweintzger, N. Gruber-Wackernagel, A. Byrne, S.N. Quehenberger, F. |
AuthorAffiliation | 4 Cellular Photoimmunology Group Infectious Diseases and Immunology Sydney Medical School The Charles Perkins Centre Hub at The University of Sydney Australia 3 Institute for Medical Informatics, Statistics and Documentation Medical University of Graz Auenbrugger Platz 8 A‐8036 Graz Austria 1 Research Unit for Photodermatology Department of Dermatology Medical University of Graz Auenbrugger Platz 8 A‐8036 Graz Austria 2 Center for Medical Research Medical University of Graz Auenbrugger Platz 8 A‐8036 Graz Austria |
AuthorAffiliation_xml | – name: 1 Research Unit for Photodermatology Department of Dermatology Medical University of Graz Auenbrugger Platz 8 A‐8036 Graz Austria – name: 2 Center for Medical Research Medical University of Graz Auenbrugger Platz 8 A‐8036 Graz Austria – name: 4 Cellular Photoimmunology Group Infectious Diseases and Immunology Sydney Medical School The Charles Perkins Centre Hub at The University of Sydney Australia – name: 3 Institute for Medical Informatics, Statistics and Documentation Medical University of Graz Auenbrugger Platz 8 A‐8036 Graz Austria |
Author_xml | – sequence: 1 givenname: N. surname: Schweintzger fullname: Schweintzger, N. organization: Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Auenbrugger Platz 8, A-8036, Graz, Austria – sequence: 2 givenname: A. surname: Gruber-Wackernagel fullname: Gruber-Wackernagel, A. organization: Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Auenbrugger Platz 8, A-8036, Graz, Austria – sequence: 3 givenname: E. surname: Reginato fullname: Reginato, E. organization: Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Auenbrugger Platz 8, A-8036, Graz, Austria – sequence: 4 givenname: I. surname: Bambach fullname: Bambach, I. organization: Center for Medical Research, Medical University of Graz, Auenbrugger Platz 8, A-8036, Graz, Austria – sequence: 5 givenname: F. surname: Quehenberger fullname: Quehenberger, F. organization: Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Auenbrugger Platz 8, A-8036, Graz, Austria – sequence: 6 givenname: S.N. surname: Byrne fullname: Byrne, S.N. organization: Cellular Photoimmunology Group, Infectious Diseases and Immunology, Sydney Medical School, The Charles Perkins Centre Hub at The University of Sydney, Australia – sequence: 7 givenname: P. surname: Wolf fullname: Wolf, P. email: peter.wolf@medunigraz.at organization: Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Auenbrugger Platz 8, A-8036, Graz, Austria |
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Cites_doi | 10.1016/j.jaci.2011.06.005 10.1046/j.1523-1747.2000.00080.x 10.1111/bjd.13479 10.4049/jimmunol.0903719 10.1111/j.1600-0781.2008.00343.x 10.1038/jid.2010.181 10.1046/j.1523-1747.2000.00079.x 10.1039/c2pp25188d 10.1046/j.0022-202X.2004.22201.x 10.1084/jem.187.12.2045 10.1111/j.1365-2133.2011.10333.x 10.1039/c1pp05009e 10.1111/bjd.13325 10.1046/j.1365-2133.2001.03897.x 10.1046/j.0022-202X.2004.22213.x 10.1111/exd.12687 10.1016/S0091-6749(03)01869-4 10.1191/096120301678416024 10.1046/j.1468-3083.2002.00443.x 10.1038/nri2785 10.1038/jid.2010.59 10.1111/bjd.12608 10.1002/dmrr.1276 10.1046/j.1529-8019.2003.01605.x 10.1073/pnas.0603642103 10.1038/jid.2008.14 10.1016/j.immuni.2009.05.002 10.4049/jimmunol.174.1.164 10.1046/j.1365-2133.2001.04339.x 10.1039/C2PP25187F 10.4049/jimmunol.175.12.8392 10.1016/j.jaci.2012.03.001 10.4049/jimmunol.178.4.2579 10.4049/jimmunol.1001657 10.1007/s00403-004-0508-x 10.1038/ni1503 10.1111/j.1600-0781.2011.00644.x 10.1111/j.1468-3083.2011.04431.x 10.1016/j.jaci.2004.01.772 10.4049/jimmunol.180.7.4648 10.1007/s00403-003-0437-0 10.1111/j.1600-0625.2009.00859.x 10.1038/nature05010 10.2340/00015555-0229 10.1046/j.1365-4362.2002.01467.x 10.1111/j.1365-2133.2004.06128.x 10.4049/jimmunol.180.5.3065 10.1111/exd.12427 10.1111/j.1600-0625.2011.01264.x 10.1016/j.det.2014.03.012 10.1038/jid.2009.250 |
ContentType | Journal Article |
Copyright | 2015 The Authors. published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. 2015 The Authors. British Journal of Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. Copyright © 2015 British Association of Dermatologists |
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Notes | ArticleID:BJD13930 FWF Austrian Science Fund - No. KLI 132-B00 Österreichische Nationalbank Anniversary Fund Medical University of Graz istex:ACA46C1A0FB55380DB400987F5682BB73BA43282 ark:/67375/WNG-B9L162HW-Z Fig S1. Flow diagram showing numbers of patients with polymorphic light eruption and healthy controls at each stage of the study.Fig S2. Peripheral blood mononuclear cells of patients and healthy controls were stained with antibodies for CD4, CD127, CD25 and FoxP3.Table S1. Characteristics of PLE patients.Table S2. Median percentages of CD4+CD25highCD127-FoxP3+ Tregs in PLE patients and healthy controls, as assessed by flow cytometry. Conflicts of interest Funding sources This work was supported by the Österreichische Nationalbank Anniversary Fund project no. 13279 and Austrian Science Fund (FWF): project number KLI 132‐B00. N.S. and E.R. were supported through the PhD programme of the Medical University of Graz, Graz, Austria. None declared. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 N.S. and A.G.‐W. contributed equally to this work. |
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References | Hart PH, Grimbaldeston MA, Swift GJ et al. Dermal mast cells determine susceptibility to ultraviolet B-induced systemic suppression of contact hypersensitivity responses in mice. J Exp Med 1998; 187:2045-53. Schwarz A, Schwarz T. UVR-induced regulatory T cells switch antigen-presenting cells from a stimulatory to a regulatory phenotype. J Invest Dermatol 2010; 130:1914-21. Gruber-Wackernagel A, Heinemann A, Konya V et al. Photohardening restores the impaired neutrophil responsiveness to chemoattractants leukotriene B4 and formyl-methionyl-leucyl-phenylalanin in patients with polymorphic light eruption. Exp Dermatol 2011; 20:473-6. Aubin F. Why is polymorphous light eruption so common in young women? Arch Dermatol Res 2004; 296:240-1. Widyarini S, Domanski D, Painter N et al. Estrogen receptor signaling protects against immune suppression by UV radiation exposure. Proc Natl Acad Sci U S A 2006; 103:12837-42. Miyara M, Amoura Z, Parizot C et al. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 2005; 175:8392-400. Milliken SVI, Wassall H, Lewis BJ et al. Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function. J Allergy Clin Immunol 2012; 129:1554-61. Chacón-Salinas R, Limón-Flores AY, Chávez-Blanco AD et al. Mast cell-derived IL-10 suppresses germinal center formation by affecting T follicular helper cell function. J Immunol 2011; 186:25-31. Millard TP, Kondeatis E, Cox A et al. A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo. Br J Dermatol 2001; 145:229-36. Millard TP, Lewis CM, Khamashta MA et al. Familial clustering of polymorphic light eruption in relatives of patients with lupus erythematosus: evidence of a shared pathogenesis. Br J Dermatol 2001; 144:334-8. Byrne SN, Limón-Flores AY, Ullrich SE. Mast cell migration from the skin to the draining lymph nodes upon ultraviolet irradiation represents a key step in the induction of immune suppression. J Immunol 2008; 180:4648-55. McGregor JM, Grabczynska S, Vaughan R et al. Genetic modeling of abnormal photosensitivity in families with polymorphic light eruption and actinic prurigo. J Invest Dermatol 2000; 115:471-6. Bock G, Prietl B, Mader JK et al. The effect of vitamin D supplementation on peripheral regulatory T cells and β cell function in healthy humans: a randomized controlled trial. Diabetes Metab Res Rev 2011; 27:942-5. Tutrone WD, Spann CT, Scheinfeld N et al. Polymorphic light eruption. Dermatol Ther 2003; 16:28-39. Zirbs M, Pürner C, Buters JTM et al. GSTM1, GSTT1 and GSTP1 gene polymorphism in polymorphous light eruption. J Eur Acad Dermatol Venereol 2013; 27:157-62. Wolf P, Byrne SN, Gruber-Wackernagel A. New insights into the mechanisms of polymorphic light eruption: resistance to ultraviolet radiation-induced immune suppression as an aetiological factor. Exp Dermatol 2009; 18:350-6. Stratigos A, Antoniou C, Katsambas A. Polymorphous light eruption. J Eur Acad Dermatol Venereol 2002; 16:193-206. Hofer A, Legat FJ, Gruber-Wackernagel A et al. Topical liposomal DNA-repair enzymes in polymorphic light eruption. Photochem Photobiol Sci 2011; 10:1118-28. Millard TP, Bataille V, Snieder H et al. The heritability of polymorphic light eruption. J Invest Dermatol 2000; 115:467-70. Lu L-F, Lind EF, Gondek DC et al. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 2006; 442:997-1002. Ibbotson SH, Bilsland D, Cox NH et al. An update and guidance on narrowband ultraviolet B phototherapy: a British Photodermatology Group Workshop Report. Br J Dermatol 2004; 151:283-97. Singh TP, Schön MP, Wallbrecht K et al. 8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis-like skin disorder. J Immunol 2010; 184:7257-67. Curotto de Lafaille MA, Lafaille JJ. Natural and adaptive Foxp3+ regulatory T cells: more of the same or a division of labor? Immunity 2009; 30:626-35. Rhodes LE, Bock M, Janssens AS et al. Polymorphic light eruption occurs in 18% of Europeans and does not show higher prevalence with increasing latitude: multicenter survey of 6,895 individuals residing from the Mediterranean to Scandinavia. J Invest Dermatol 2010; 130:626-8. Hönigsmann H. Polymorphous light eruption. Photodermatol Photoimmunol Photomed 2008; 24:155-61. Ou L-S, Goleva E, Hall C et al. T regulatory cells in atopic dermatitis and subversion of their activity by superantigens. J Allergy Clin Immunol 2004; 113:756-63. Palmer RA, Friedmann PS. Ultraviolet radiation causes less immunosuppression in patients with polymorphic light eruption than in controls. J Invest Dermatol 2004; 122:291-4. Millard TP, Kondeatis E, Vaughan RW et al. Polymorphic light eruption and the HLA DRB1*0301 extended haplotype are independent risk factors for cutaneous lupus erythematosus. Lupus 2001; 10:473-9. Grimbaldeston MA, Nakae S, Kalesnikoff J et al. Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nat Immunol 2007; 8:1095-104. Rhodes LE, Webb AR, Berry JL et al. Sunlight exposure behaviour and vitamin D status in photosensitive patients: longitudinal comparative study with healthy individuals at U.K. latitude. Br J Dermatol 2014; 171:1478-86. Wolf P, Gruber-Wackernagel A, Rinner B et al. Phototherapeutic hardening modulates systemic cytokine levels in patients with polymorphic light eruption. Photochem Photobiol Sci 2013; 12:166-73. Umetsu DT, Akbari O, Dekruyff RH. Regulatory T cells control the development of allergic disease and asthma. J Allergy Clin Immunol 2003; 112:480-7. Hiramoto K, Tanaka H, Yanagihara N et al. Effect of 17beta-estradiol on immunosuppression induced by ultraviolet B irradiation. Arch Dermatol Res 2004; 295:307-11. Wolf P, Gruber-Wackernagel A, Bambach I et al. Photohardening of polymorphic light eruption patients decreases baseline epidermal Langerhans cell density while increasing mast cell numbers in the papillary dermis. Exp Dermatol 2014; 23:428-30. Koulu LM, Laihia JK, Peltoniemi H-H et al. UV-induced tolerance to a contact allergen is impaired in polymorphic light eruption. J Invest Dermatol 2010; 130:2578-82. Prietl B, Pilz S, Wolf M et al. Vitamin D supplementation and regulatory T cells in apparently healthy subjects: vitamin D treatment for autoimmune diseases? Isr Med Assoc J 2010; 12:136-9. Lim HW, Snauwaert JJL. Vitamin D and photodermatoses. Br J Dermatol 2014; 171:1297-8. Guarrera M, Rebora A. Serum antioxidant capacity in polymorphic light eruption. Acta Derm Venereol 2007; 87:228-30. Naleway AL. Polymorphous light eruption. Int J Dermatol 2002; 41:377-83. Gruber-Wackernagel A, Obermayer-Pietsch B, Byrne SN et al. Patients with polymorphic light eruption have decreased serum levels of 25-hydroxyvitamin-D3 that increase upon 311 nm UVB photohardening. Photochem Photobiol Sci 2012; 11:1831-6. Schwarz A, Navid F, Sparwasser T et al. In vivo reprogramming of UV radiation-induced regulatory T-cell migration to inhibit the elicitation of contact hypersensitivity. J Allergy Clin Immunol 2011; 128:826-33. Sugiyama H, Gyulai R, Toichi E et al. Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation. J Immunol 2005; 174:164-73. Millard TP, Fryer AA, McGregor JM. A protective effect of glutathione-S-transferase GSTP1*Val(105) against polymorphic light eruption. J Invest Dermatol 2008; 128:1901-5. Valencia X, Yarboro C, Illei G et al. Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 2007; 178:2579-88. Reid SM, Robinson M, Kerr AC et al. Prevalence and predictors of low vitamin D status in patients referred to a tertiary photodiagnostic service: a retrospective study. Photodermatol Photoimmunol Photomed 2012; 28:91-6. Gruber-Wackernagel A, Bambach I, Legat FJ et al. Randomized double-blinded placebo-controlled intra-individual trial on topical treatment with a 1,25-dihydroxyvitamin D₃ analogue in polymorphic light eruption. Br J Dermatol 2011; 165:152-63. Maeda A, Beissert S, Schwarz T et al. Phenotypic and functional characterization of ultraviolet radiation-induced regulatory T cells. J Immunol 2008; 180:3065-71. Gruber-Wackernagel A, Byrne SN, Wolf P. Polymorphous light eruption: clinic aspects and pathogenesis. Dermatol Clin 2014; 32:315-34. Van de Pas CB, Kelly DA, Seed PT et al. Ultraviolet-radiation-induced erythema and suppression of contact hypersensitivity responses in patients with polymorphic light eruption. J Invest Dermatol 2004; 122:295-9. Sakaguchi S, Miyara M, Costantino CM et al. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 2010; 10:490-500. Schweintzger N, BambachI, Reginato E et al. Mast cells are required for phototolerance induction and scratching abatement. Exp Dermatol 2015; 24:491-30. Gambichler T, Terras S, Kampilafkos P et al. T regulatory cells and related immunoregulatory factors in polymorphic light eruption following ultraviolet al challenge. Br J Dermatol 2013; 169:1288-94. 2002; 16 2001; 144 2010; 12 2004; 122 2010; 10 2001; 145 2005; 174 2005; 175 2013; 27 2000; 115 2013; 169 2003; 16 2011; 10 2008; 128 2010; 184 2014; 171 2003; 112 2012; 11 2014; 23 2012; 129 2015; 24 2008; 180 2007; 178 2004; 296 2009; 30 2011; 128 2004; 113 2002; 41 2013; 12 2004; 295 2004; 151 2007; 8 2011; 20 2010; 130 2008; 24 2012; 28 2007; 87 1998; 187 2011; 27 2006; 442 2014; 32 2009; 18 2006; 103 2011; 165 2001; 10 2011; 186 26346086 - Br J Dermatol. 2015 Aug;173(2):330-1 e_1_2_6_51_1 e_1_2_6_53_1 e_1_2_6_32_1 e_1_2_6_30_1 e_1_2_6_19_1 e_1_2_6_13_1 e_1_2_6_36_1 e_1_2_6_11_1 e_1_2_6_17_1 e_1_2_6_15_1 e_1_2_6_38_1 e_1_2_6_43_1 e_1_2_6_20_1 e_1_2_6_41_1 e_1_2_6_9_1 e_1_2_6_5_1 e_1_2_6_7_1 e_1_2_6_24_1 e_1_2_6_3_1 e_1_2_6_22_1 e_1_2_6_28_1 e_1_2_6_45_1 e_1_2_6_26_1 e_1_2_6_47_1 e_1_2_6_52_1 e_1_2_6_10_1 e_1_2_6_31_1 e_1_2_6_50_1 e_1_2_6_14_1 e_1_2_6_35_1 e_1_2_6_12_1 e_1_2_6_33_1 e_1_2_6_18_1 e_1_2_6_39_1 e_1_2_6_16_1 e_1_2_6_37_1 Guarrera M (e_1_2_6_34_1) 2007; 87 e_1_2_6_42_1 e_1_2_6_21_1 e_1_2_6_40_1 Prietl B (e_1_2_6_49_1) 2010; 12 e_1_2_6_8_1 e_1_2_6_4_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_48_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_29_1 e_1_2_6_44_1 e_1_2_6_27_1 e_1_2_6_46_1 |
References_xml | – volume: 12 start-page: 136 year: 2010 end-page: 9 article-title: Vitamin D supplementation and regulatory T cells in apparently healthy subjects: vitamin D treatment for autoimmune diseases? publication-title: Isr Med Assoc J – volume: 295 start-page: 307 year: 2004 end-page: 11 article-title: Effect of 17beta‐estradiol on immunosuppression induced by ultraviolet B irradiation publication-title: Arch Dermatol Res – volume: 130 start-page: 1914 year: 2010 end-page: 21 article-title: UVR‐induced regulatory T cells switch antigen‐presenting cells from a stimulatory to a regulatory phenotype publication-title: J Invest Dermatol – volume: 10 start-page: 490 year: 2010 end-page: 500 article-title: FOXP3+ regulatory T cells in the human immune system publication-title: Nat Rev Immunol – volume: 27 start-page: 942 year: 2011 end-page: 5 article-title: The effect of vitamin D supplementation on peripheral regulatory T cells and β cell function in healthy humans: a randomized controlled trial publication-title: Diabetes Metab Res Rev – volume: 16 start-page: 193 year: 2002 end-page: 206 article-title: Polymorphous light eruption publication-title: J Eur Acad Dermatol Venereol – volume: 115 start-page: 467 year: 2000 end-page: 70 article-title: The heritability of polymorphic light eruption publication-title: J Invest Dermatol – volume: 122 start-page: 291 year: 2004 end-page: 4 article-title: Ultraviolet radiation causes less immunosuppression in patients with polymorphic light eruption than in controls publication-title: J Invest Dermatol – volume: 128 start-page: 1901 year: 2008 end-page: 5 article-title: A protective effect of glutathione‐S‐transferase GSTP1*Val(105) against polymorphic light eruption publication-title: J Invest Dermatol – volume: 169 start-page: 1288 year: 2013 end-page: 94 article-title: T regulatory cells and related immunoregulatory factors in polymorphic light eruption following ultraviolet al challenge publication-title: Br J Dermatol – volume: 10 start-page: 1118 year: 2011 end-page: 28 article-title: Topical liposomal DNA‐repair enzymes in polymorphic light eruption publication-title: Photochem Photobiol Sci – volume: 11 start-page: 1831 year: 2012 end-page: 6 article-title: Patients with polymorphic light eruption have decreased serum levels of 25‐hydroxyvitamin‐D3 that increase upon 311 nm UVB photohardening publication-title: Photochem Photobiol Sci – volume: 165 start-page: 152 year: 2011 end-page: 63 article-title: Randomized double‐blinded placebo‐controlled intra‐individual trial on topical treatment with a 1,25‐dihydroxyvitamin D₃ analogue in polymorphic light eruption publication-title: Br J Dermatol – volume: 23 start-page: 428 year: 2014 end-page: 30 article-title: Photohardening of polymorphic light eruption patients decreases baseline epidermal Langerhans cell density while increasing mast cell numbers in the papillary dermis publication-title: Exp Dermatol – volume: 103 start-page: 12837 year: 2006 end-page: 42 article-title: Estrogen receptor signaling protects against immune suppression by UV radiation exposure publication-title: Proc Natl Acad Sci U S A – volume: 174 start-page: 164 year: 2005 end-page: 73 article-title: Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation publication-title: J Immunol – volume: 442 start-page: 997 year: 2006 end-page: 1002 article-title: Mast cells are essential intermediaries in regulatory T‐cell tolerance publication-title: Nature – volume: 180 start-page: 4648 year: 2008 end-page: 55 article-title: Mast cell migration from the skin to the draining lymph nodes upon ultraviolet irradiation represents a key step in the induction of immune suppression publication-title: J Immunol – volume: 20 start-page: 473 year: 2011 end-page: 6 article-title: Photohardening restores the impaired neutrophil responsiveness to chemoattractants leukotriene B4 and formyl‐methionyl‐leucyl‐phenylalanin in patients with polymorphic light eruption publication-title: Exp Dermatol – volume: 296 start-page: 240 year: 2004 end-page: 1 article-title: Why is polymorphous light eruption so common in young women? publication-title: Arch Dermatol Res – volume: 30 start-page: 626 year: 2009 end-page: 35 article-title: Natural and adaptive Foxp3+ regulatory T cells: more of the same or a division of labor? publication-title: Immunity – volume: 187 start-page: 2045 year: 1998 end-page: 53 article-title: Dermal mast cells determine susceptibility to ultraviolet B‐induced systemic suppression of contact hypersensitivity responses in mice publication-title: J Exp Med – volume: 112 start-page: 480 year: 2003 end-page: 7 article-title: Regulatory T cells control the development of allergic disease and asthma publication-title: J Allergy Clin Immunol – volume: 115 start-page: 471 year: 2000 end-page: 6 article-title: Genetic modeling of abnormal photosensitivity in families with polymorphic light eruption and actinic prurigo publication-title: J Invest Dermatol – volume: 12 start-page: 166 year: 2013 end-page: 73 article-title: Phototherapeutic hardening modulates systemic cytokine levels in patients with polymorphic light eruption publication-title: Photochem Photobiol Sci – volume: 122 start-page: 295 year: 2004 end-page: 9 article-title: Ultraviolet‐radiation‐induced erythema and suppression of contact hypersensitivity responses in patients with polymorphic light eruption publication-title: J Invest Dermatol – volume: 32 start-page: 315 year: 2014 end-page: 34 article-title: Polymorphous light eruption: clinic aspects and pathogenesis publication-title: Dermatol Clin – volume: 145 start-page: 229 year: 2001 end-page: 36 article-title: A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo publication-title: Br J Dermatol – volume: 113 start-page: 756 year: 2004 end-page: 63 article-title: T regulatory cells in atopic dermatitis and subversion of their activity by superantigens publication-title: J Allergy Clin Immunol – volume: 24 start-page: 155 year: 2008 end-page: 61 article-title: Polymorphous light eruption publication-title: Photodermatol Photoimmunol Photomed – volume: 28 start-page: 91 year: 2012 end-page: 6 article-title: Prevalence and predictors of low vitamin D status in patients referred to a tertiary photodiagnostic service: a retrospective study publication-title: Photodermatol Photoimmunol Photomed – volume: 171 start-page: 1297 year: 2014 end-page: 8 article-title: Vitamin D and photodermatoses publication-title: Br J Dermatol – volume: 151 start-page: 283 year: 2004 end-page: 97 article-title: An update and guidance on narrowband ultraviolet B phototherapy: a British Photodermatology Group Workshop Report publication-title: Br J Dermatol – volume: 27 start-page: 157 year: 2013 end-page: 62 article-title: GSTM1, GSTT1 and GSTP1 gene polymorphism in polymorphous light eruption publication-title: J Eur Acad Dermatol Venereol – volume: 178 start-page: 2579 year: 2007 end-page: 88 article-title: Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus publication-title: J Immunol – volume: 175 start-page: 8392 year: 2005 end-page: 400 article-title: Global natural regulatory T cell depletion in active systemic lupus erythematosus publication-title: J Immunol – volume: 18 start-page: 350 year: 2009 end-page: 6 article-title: New insights into the mechanisms of polymorphic light eruption: resistance to ultraviolet radiation‐induced immune suppression as an aetiological factor publication-title: Exp Dermatol – volume: 171 start-page: 1478 year: 2014 end-page: 86 article-title: Sunlight exposure behaviour and vitamin D status in photosensitive patients: longitudinal comparative study with healthy individuals at U.K. latitude publication-title: Br J Dermatol – volume: 144 start-page: 334 year: 2001 end-page: 8 article-title: Familial clustering of polymorphic light eruption in relatives of patients with lupus erythematosus: evidence of a shared pathogenesis publication-title: Br J Dermatol – volume: 10 start-page: 473 year: 2001 end-page: 9 article-title: Polymorphic light eruption and the HLA DRB1*0301 extended haplotype are independent risk factors for cutaneous lupus erythematosus publication-title: Lupus – volume: 8 start-page: 1095 year: 2007 end-page: 104 article-title: Mast cell‐derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B publication-title: Nat Immunol – volume: 41 start-page: 377 year: 2002 end-page: 83 article-title: Polymorphous light eruption publication-title: Int J Dermatol – volume: 130 start-page: 626 year: 2010 end-page: 8 article-title: Polymorphic light eruption occurs in 18% of Europeans and does not show higher prevalence with increasing latitude: multicenter survey of 6,895 individuals residing from the Mediterranean to Scandinavia publication-title: J Invest Dermatol – volume: 87 start-page: 228 year: 2007 end-page: 30 article-title: Serum antioxidant capacity in polymorphic light eruption publication-title: Acta Derm Venereol – volume: 24 start-page: 491 year: 2015 end-page: 30 article-title: Mast cells are required for phototolerance induction and scratching abatement publication-title: Exp Dermatol – volume: 180 start-page: 3065 year: 2008 end-page: 71 article-title: Phenotypic and functional characterization of ultraviolet radiation‐induced regulatory T cells publication-title: J Immunol – volume: 129 start-page: 1554 year: 2012 end-page: 61 article-title: Effects of ultraviolet light on human serum 25‐hydroxyvitamin D and systemic immune function publication-title: J Allergy Clin Immunol – volume: 16 start-page: 28 year: 2003 end-page: 39 article-title: Polymorphic light eruption publication-title: Dermatol Ther – volume: 186 start-page: 25 year: 2011 end-page: 31 article-title: Mast cell‐derived IL‐10 suppresses germinal center formation by affecting T follicular helper cell function publication-title: J Immunol – volume: 128 start-page: 826 year: 2011 end-page: 33 article-title: reprogramming of UV radiation‐induced regulatory T‐cell migration to inhibit the elicitation of contact hypersensitivity publication-title: J Allergy Clin Immunol – volume: 184 start-page: 7257 year: 2010 end-page: 67 article-title: 8‐methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL‐23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis‐like skin disorder publication-title: J Immunol – volume: 130 start-page: 2578 year: 2010 end-page: 82 article-title: UV‐induced tolerance to a contact allergen is impaired in polymorphic light eruption publication-title: J Invest Dermatol – ident: e_1_2_6_12_1 doi: 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Snippet | Summary
Background
We hypothesized that regulatory T cells (Tregs) are involved in the immunological abnormalities seen in patients with polymorphic light... We hypothesized that regulatory T cells (Tregs) are involved in the immunological abnormalities seen in patients with polymorphic light eruption (PLE). To... BackgroundWe hypothesized that regulatory T cells (Tregs) are involved in the immunological abnormalities seen in patients with polymorphic light eruption... BACKGROUNDWe hypothesized that regulatory T cells (Tregs) are involved in the immunological abnormalities seen in patients with polymorphic light eruption... What's already known about this topic? Patients with polymorphic light eruption (PLE) display immunological abnormalities. Previous studies have shown that... |
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SubjectTerms | Adolescent Adult Aged CD25 antigen CD4 antigen Cell proliferation Cell Proliferation - physiology Effector cells Female Flow cytometry Forkhead Transcription Factors - metabolism Foxp3 protein Gene expression Humans Immune system Immunoregulation Light therapy Lymphocytes Lymphocytes T Male Middle Aged mRNA Original Photobiology Photosensitivity Disorders - immunology Photosensitivity Disorders - metabolism Photosensitivity Disorders - radiotherapy Phototherapy Seasons Skin eruptions Statistical analysis T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - physiology Ultraviolet Therapy - methods Up-Regulation - physiology Young Adult |
Title | Levels and function of regulatory T cells in patients with polymorphic light eruption: relation to photohardening |
URI | https://api.istex.fr/ark:/67375/WNG-B9L162HW-Z/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fbjd.13930 https://www.ncbi.nlm.nih.gov/pubmed/26032202 https://www.proquest.com/docview/2311142424/abstract/ https://search.proquest.com/docview/1710657395 https://pubmed.ncbi.nlm.nih.gov/PMC4564948 |
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