Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 6; no. 4; pp. 537 - 544
• Main Authors: Zhang, Liming, Xia, Jingguang, Zhao, Qinghuan, Liu, Liwei, Zhang, Zhijun
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 22.02.2010; WILEY‐VCH Verlag
• Subjects: Antineoplastic Agents - pharmacology; Antitumor agents; Breast cancer; Camptothecin; Camptothecin - pharmacology; cancer therapy; Carbon - chemistry; Cell Line, Tumor; Cell Survival - drug effects; Cytotoxicity; Doxorubicin; Doxorubicin - pharmacology; Drug Carriers - chemistry; drug delivery; Drug Delivery Systems - methods; Folic acid; Folic Acid - chemistry; graphene oxide; Humans; Hydrophobicity; Microscopy, Atomic Force; nanomaterials; oxides; Rhodamines - metabolism; Solutions; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Stacking; sulfonic acid

A simple synthetic route for the preparation of functional nanoscale graphene oxide (NGO), a novel nanocarrier for the loading and targeted delivery of anticancer drugs, is reported. The NGO is functionalized with sulfonic acid groups, which render it stable in physiological solution, followed by co...