Multilocus Sequence Typing of Streptococcus pyogenes Representing Most Known emm Types and Distinctions among Subpopulation Genetic Structures

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Published inJournal of Bacteriology Vol. 186; no. 13; pp. 4285 - 4294
Main Authors McGregor, Karen F., Spratt, Brian G., Kalia, Awdhesh, Bennett, Alicia, Bilek, Nicole, Beall, Bernard, Bessen, Debra E.
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.07.2004
Subjects
Antigens, Bacterial - classification
Bacterial Outer Membrane Proteins - classification
Bacteriology
Biological and medical sciences
Carrier Proteins - classification
Chromosome Mapping
Fundamental and applied biological sciences. Psychology
Gene loci
Genetic diversity
Genetic structure
Genetic Variation
Microbiology
Miscellaneous
Population genetics
Population Genetics and Evolution
Streptococcus pyogenes
Streptococcus pyogenes - classification
Streptococcus pyogenes - genetics
Subpopulations
Tissues
Streptococcaceae
Microbiology
Bacteria
Micrococcales
Genotype
Genetics
Streptococcus pyogenes
Bacteriology
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Abstract Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JB About JB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0021-9193 Online ISSN: 1098-5530 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JB .asm.org, visit: JB       
AbstractList A long-term goal is to characterize the full range of genetic diversity within Streptococcus pyogenes as it exists in the world today. Since the emm locus is subject to strong diversifying selection, emm type was used as a guide for identifying a genetically diverse set of strains. This report contains a description of multilocus sequence typing based on seven housekeeping loci for 495 isolates representing 158 emm types, yielding 238 unique combinations of sequence type and emm type. A genotypic marker for tissue site preference ( emm pattern) revealed that only 17% of the emm types displayed the marker representing strong preference for infection at the throat and that 39% of emm types had the marker for skin tropism, whereas 41% of emm types harbored the marker for no obvious tissue site preference. As a group, the emm types bearing the emm pattern marker indicative of no obvious tissue site preference were far less likely to have two distinct emm types associated with the same sequence type than either of the two subpopulations having markers for strong tissue tropisms ( P < 0.002). In addition, all genetic diversification events clearly ascribed to a recombinational mechanism involved strains of only two of the emm pattern-defined subpopulations, those representing skin specialists and generalists. The findings suggest that the population genetic structure differs for the tissue-defined subpopulations of S. pyogenes . The observed differences may partly reflect differential host immune selection pressures.
A long-term goal is to characterize the full range of genetic diversity within Streptococcus pyogenes as it exists in the world today. Since the emm locus is subject to strong diversifying selection, emm type was used as a guide for identifying a genetically diverse set of strains. This report contains a description of multilocus sequence typing based on seven housekeeping loci for 495 isolates representing 158 emm types, yielding 238 unique combinations of sequence type and emm type. A genotypic marker for tissue site preference (emm pattern) revealed that only 17% of the emm types displayed the marker representing strong preference for infection at the throat and that 39% of emm types had the marker for skin tropism, whereas 41% of emm types harbored the marker for no obvious tissue site preference. As a group, the emm types bearing the emm pattern marker indicative of no obvious tissue site preference were far less likely to have two distinct emm types associated with the same sequence type than either of the two subpopulations having markers for strong tissue tropisms (P < 0.002). In addition, all genetic diversification events clearly ascribed to a recombinational mechanism involved strains of only two of the emm pattern- defined subpopulations, those representing skin specialists and generalists. The findings suggest that the population genetic structure differs for the tissue- defined subpopulations of S. pyogenes. The observed differences may partly reflect differential host immune selection pressures.
Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JB About JB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0021-9193 Online ISSN: 1098-5530 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JB .asm.org, visit: JB       
A long-term goal is to characterize the full range of genetic diversity within Streptococcus pyogenes as it exists in the world today. Since the emm locus is subject to strong diversifying selection, emm type was used as a guide for identifying a genetically diverse set of strains. This report contains a description of multilocus sequence typing based on seven housekeeping loci for 495 isolates representing 158 emm types, yielding 238 unique combinations of sequence type and emm type. A genotypic marker for tissue site preference (emm pattern) revealed that only 17% of the emm types displayed the marker representing strong preference for infection at the throat and that 39% of emm types had the marker for skin tropism, whereas 41% of emm types harbored the marker for no obvious tissue site preference. As a group, the emm types bearing the emm pattern marker indicative of no obvious tissue site preference were far less likely to have two distinct emm types associated with the same sequence type than either of the two subpopulations having markers for strong tissue tropisms (P < 0.002). In addition, all genetic diversification events clearly ascribed to a recombinational mechanism involved strains of only two of the emm pattern-defined subpopulations, those representing skin specialists and generalists. The findings suggest that the population genetic structure differs for the tissue-defined subpopulations of S. pyogenes. The observed differences may partly reflect differential host immune selection pressures. [PUBLICATION ABSTRACT]
Author Bernard Beall
Alicia Bennett
Awdhesh Kalia
Debra E. Bessen
Brian G. Spratt
Nicole Bilek
Karen F. McGregor
AuthorAffiliation Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom, 1 Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, 2 Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, 3 Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, 4 Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 5
AuthorAffiliation_xml – name: Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom, 1 Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, 2 Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, 3 Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, 4 Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 5
Author_xml – sequence: 1
  givenname: Karen F.
  surname: McGregor
  fullname: McGregor, Karen F.
  organization: Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
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  givenname: Brian G.
  surname: Spratt
  fullname: Spratt, Brian G.
  organization: Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
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  givenname: Awdhesh
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  fullname: Kalia, Awdhesh
  organization: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut
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  givenname: Alicia
  surname: Bennett
  fullname: Bennett, Alicia
  organization: Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut
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  organization: Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
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  organization: Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia
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  givenname: Debra E.
  surname: Bessen
  fullname: Bessen, Debra E.
  organization: Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, Department of Microbiology and Immunology, New York Medical College, Valhalla, New York
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Issue 13
Keywords Streptococcaceae
Microbiology
Bacteria
Micrococcales
Genotype
Genetics
Streptococcus pyogenes
Bacteriology
Language English
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Corresponding author. Mailing address: New York Medical College, Department of Microbiology & Immunology, Valhalla, NY 10595. Phone: (914) 594-4193. Fax: (914) 594-4176. E-mail: debra_bessen@nymc.edu.
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A long-term goal is to characterize the full range of genetic diversity within Streptococcus pyogenes as it exists in the world today. Since the emm locus is...
A long-term goal is to characterize the full range of genetic diversity within Streptococcus pyogenes as it exists in the world today. Since the emm locus is...
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StartPage 4285
SubjectTerms Antigens, Bacterial - classification
Bacterial Outer Membrane Proteins - classification
Bacteriology
Biological and medical sciences
Carrier Proteins - classification
Chromosome Mapping
Fundamental and applied biological sciences. Psychology
Gene loci
Genetic diversity
Genetic structure
Genetic Variation
Microbiology
Miscellaneous
Population genetics
Population Genetics and Evolution
Streptococcus pyogenes
Streptococcus pyogenes - classification
Streptococcus pyogenes - genetics
Subpopulations
Tissues
Title Multilocus Sequence Typing of Streptococcus pyogenes Representing Most Known emm Types and Distinctions among Subpopulation Genetic Structures
URI http://jb.asm.org/content/186/13/4285.abstract
https://www.ncbi.nlm.nih.gov/pubmed/15205431
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https://www.proquest.com/docview/17987727
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https://pubmed.ncbi.nlm.nih.gov/PMC421626
Volume 186
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