Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosin

• Published in: BMC pharmacology & toxicology Vol. 25; no. 1; p. 30
• Main Authors: Tian, Chunyan, Liu, Qi, Zhang, Xiaoyu, Li, Zhuying
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.04.2024; BioMed Central
• Subjects: Albumin; Analysis; Animal models; Antibodies; Arginase; Asthma; Astragalus membranaceus; Bioflavonoids; Biotechnology industry; Bronchus; Cell activation; Cell culture; Cells; Chitinase; Cloning; Cytokines; Drug development; Eosinophils; Flavones; Flavonoids; Health aspects; House dust; In vivo methods and tests; Inflammation; Interleukin 10; Interleukin 13; Interleukin 4; Interleukin 5; Interleukins; Kinases; Laboratory animals; Lavage; Leukocytes (eosinophilic); Leukocytes (neutrophilic); Lungs; Lymphocytes; Lymphoid cells; Macrophages; Mannose; Monocytes; Ovalbumin; Polarization; Respiratory tract diseases; Tumorigenicity; Japan; China; Beijing China; United States > US; Group 2 innate lymphoid cells; Calycosin; Macrophages; Asthma

Calycosin, a flavonoid compound extracted from Astragalus membranaceus, has shown anti-asthma benefits in house dust mite-induced asthma. Recent studies have suggested that innate-type cells, including group 2 innate lymphoid cells (ILC2s) and macrophages, serve as incentives for type 2 immunity and...