Human intestinal microbial metabolism of naringin
Naringin, a major flavonoid in citrus fruits, has been proved to be a promising antitussive candidate. It undertakes complicated metabolism. In this study, human intestinal microbial metabolism of naringin was studied in vitro. Six persons’ fecal water, which have intestinal microbial enzyme, were u...
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| Published in | European journal of drug metabolism and pharmacokinetics Vol. 40; no. 3; pp. 363 - 367 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Springer International Publishing
01.09.2015
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| Abstract | Naringin, a major flavonoid in citrus fruits, has been proved to be a promising antitussive candidate. It undertakes complicated metabolism. In this study, human intestinal microbial metabolism of naringin was studied in vitro. Six persons’ fecal water, which have intestinal microbial enzyme, were used in the first experiment. Naringin was metabolized by fecal water into naringenin. Subsequently, 3-(4-hydroxyphenyl)propionic acid (4-HPPA) was produced with naringenin degradation by a person’s fecal water. However, 4-HPPA was not detected after naringenin degradation by the other 5 subjects’ fecal water and the reason might be that the degrading velocity of 4-HPPA exceeded the producing velocity. To confirm the difference in degrading 4-HPPA among human feces, 22 healthy persons’ feces were used for incubation. In this second experiment, 15 persons’ feces could degrade 4-HPPA, but the other 7 subjects’ could not. Human feces showed different ability of degrading 4-HPPA, and there are no gender differences. These results may be helpful for explaining findings in pharmacological and toxicological studies and are groundwork for clinical studies. |
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| AbstractList | Naringin, a major flavonoid in citrus fruits, has been proved to be a promising antitussive candidate. It undertakes complicated metabolism. In this study, human intestinal microbial metabolism of naringin was studied in vitro. Six persons' fecal water, which have intestinal microbial enzyme, were used in the first experiment. Naringin was metabolized by fecal water into naringenin. Subsequently, 3-(4-hydroxyphenyl)propionic acid (4-HPPA) was produced with naringenin degradation by a person's fecal water. However, 4-HPPA was not detected after naringenin degradation by the other 5 subjects' fecal water and the reason might be that the degrading velocity of 4-HPPA exceeded the producing velocity. To confirm the difference in degrading 4-HPPA among human feces, 22 healthy persons' feces were used for incubation. In this second experiment, 15 persons' feces could degrade 4-HPPA, but the other 7 subjects' could not. Human feces showed different ability of degrading 4-HPPA, and there are no gender differences. These results may be helpful for explaining findings in pharmacological and toxicological studies and are groundwork for clinical studies. Naringin, a major flavonoid in citrus fruits, has been proved to be a promising antitussive candidate. It undertakes complicated metabolism. In this study, human intestinal microbial metabolism of naringin was studied in vitro. Six persons' fecal water, which have intestinal microbial enzyme, were used in the first experiment. Naringin was metabolized by fecal water into naringenin. Subsequently, 3-(4-hydroxyphenyl)propionic acid (4-HPPA) was produced with naringenin degradation by a person's fecal water. However, 4-HPPA was not detected after naringenin degradation by the other 5 subjects' fecal water and the reason might be that the degrading velocity of 4-HPPA exceeded the producing velocity. To confirm the difference in degrading 4-HPPA among human feces, 22 healthy persons' feces were used for incubation. In this second experiment, 15 persons' feces could degrade 4-HPPA, but the other 7 subjects' could not. Human feces showed different ability of degrading 4-HPPA, and there are no gender differences. These results may be helpful for explaining findings in pharmacological and toxicological studies and are groundwork for clinical studies.Naringin, a major flavonoid in citrus fruits, has been proved to be a promising antitussive candidate. It undertakes complicated metabolism. In this study, human intestinal microbial metabolism of naringin was studied in vitro. Six persons' fecal water, which have intestinal microbial enzyme, were used in the first experiment. Naringin was metabolized by fecal water into naringenin. Subsequently, 3-(4-hydroxyphenyl)propionic acid (4-HPPA) was produced with naringenin degradation by a person's fecal water. However, 4-HPPA was not detected after naringenin degradation by the other 5 subjects' fecal water and the reason might be that the degrading velocity of 4-HPPA exceeded the producing velocity. To confirm the difference in degrading 4-HPPA among human feces, 22 healthy persons' feces were used for incubation. In this second experiment, 15 persons' feces could degrade 4-HPPA, but the other 7 subjects' could not. Human feces showed different ability of degrading 4-HPPA, and there are no gender differences. These results may be helpful for explaining findings in pharmacological and toxicological studies and are groundwork for clinical studies. |
| Author | Su, Weiwei Zhang, Kejian Zou, Wei Chen, Si Liu, Menghua Luo, Yulong Wang, Sheng Nie, Yichu Cheng, Guohua |
| Author_xml | – sequence: 1 givenname: Wei surname: Zou fullname: Zou, Wei organization: Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Science, Sun Yat-sen University – sequence: 2 givenname: Yulong surname: Luo fullname: Luo, Yulong organization: Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Science, Sun Yat-sen University – sequence: 3 givenname: Menghua surname: Liu fullname: Liu, Menghua organization: Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Science, Sun Yat-sen University – sequence: 4 givenname: Si surname: Chen fullname: Chen, Si organization: Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Science, Sun Yat-sen University – sequence: 5 givenname: Sheng surname: Wang fullname: Wang, Sheng organization: Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Science, Sun Yat-sen University – sequence: 6 givenname: Yichu surname: Nie fullname: Nie, Yichu organization: Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Science, Sun Yat-sen University – sequence: 7 givenname: Guohua surname: Cheng fullname: Cheng, Guohua organization: Pharmacy College, Jinan University – sequence: 8 givenname: Weiwei surname: Su fullname: Su, Weiwei email: lssswwhk@gmail.com organization: Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Science, Sun Yat-sen University – sequence: 9 givenname: Kejian surname: Zhang fullname: Zhang, Kejian email: zkj5566@sohu.com organization: School of Pharmaceutical Sciences, Sun Yat-Sen University |
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| Cites_doi | 10.1016/j.ejphar.2012.06.040 10.1007/s00203-004-0676-2 10.1042/bj1301161 10.1007/BF03216747 10.1002/bdd.1775 10.1128/AEM.71.10.6077-6085.2005 10.1007/BF02973933 10.1016/j.anaerobe.2005.11.002 10.1016/j.intimp.2011.05.022 10.1128/MMBR.65.4.523-569.2001 10.1089/jmf.2012.2251 10.1055/s-0030-1250117 10.1007/s002030050010 10.1006/bbrc.2001.5001 10.1055/s-0031-1299746 10.1124/dmd.32.4.387 10.1007/s00394-003-0397-3 10.1016/j.intimp.2012.04.019 10.1016/j.freeradbiomed.2003.09.022 10.1021/jf0108056 10.1159/000139228 10.1007/s11101-008-9095-3 10.1016/0891-5849(90)90045-K 10.1016/j.etap.2011.01.006 10.1248/cpb.49.1640 10.1093/jn/135.1.48 10.1093/jn/136.6.1477 10.1093/jn/131.10.2648 |
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| Keywords | 3-(4-Hydroxyphenyl)propionic acid Naringin Metabolism Human intestinal microbiota |
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| Snippet | Naringin, a major flavonoid in citrus fruits, has been proved to be a promising antitussive candidate. It undertakes complicated metabolism. In this study,... |
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| SubjectTerms | Bacteria - metabolism Biomedical and Life Sciences Biomedicine Feces - chemistry Female Flavanones - metabolism Flavonoids - metabolism Human Physiology Humans Intestines - metabolism Intestines - microbiology Male Medical Biochemistry Pharmaceutical Sciences/Technology Pharmacology/Toxicology Pharmacy Phenylpropionates - metabolism Short Communication |
| Title | Human intestinal microbial metabolism of naringin |
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