Expression of HMGR and corresponding cholesterol content in tissues of two pig breeds
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is an essential enzyme in cholesterol biosynthesis. To study the expression of HMGR and corresponding cholesterol content in liver, adipose and muscle, six Chinese local breed (Huai pig) and Landrace pigs were selected. The results indicated that s...
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Published in | Animal (Cambridge, England) Vol. 3; no. 10; pp. 1436 - 1441 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Cambridge University Press
01.10.2009
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Abstract | The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is an essential enzyme in cholesterol biosynthesis. To study the expression of HMGR and corresponding cholesterol content in liver, adipose and muscle, six Chinese local breed (Huai pig) and Landrace pigs were selected. The results indicated that significant differences of cholesterol content in adipose (P < 0.01), liver (P < 0.05) and muscle (P < 0.01) tissues were detected between pigs of differing genetic backgrounds. HMGR mRNA expression were noted for adipose, liver and muscle of the two vastly differing genetics. Moreover cholesterol content differed (P < 0.01) among tissues across breed. Likewise, HMGR mRNA expression was different between adipose and liver tissues, muscle and liver tissues in both breeds; however, no difference was noted between adipose and muscle tissues. Results from this study indicate that cholesterol content and HMGR mRNA expression are higher in Huai pig tissues suggesting this gene is expressed in a breed- and tissue-dependent manner in pigs. Understanding the causes of variation in HMGR gene expression may provide crucial information about cholesterol biosynthesis. |
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AbstractList | The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is an essential enzyme in cholesterol biosynthesis. To study the expression of HMGR and corresponding cholesterol content in liver, adipose and muscle, six Chinese local breed (Huai pig) and Landrace pigs were selected. The results indicated that significant differences of cholesterol content in adipose (P < 0.01), liver (P < 0.05) and muscle (P < 0.01) tissues were detected between pigs of differing genetic backgrounds. HMGR mRNA expression were noted for adipose, liver and muscle of the two vastly differing genetics. Moreover cholesterol content differed (P < 0.01) among tissues across breed. Likewise, HMGR mRNA expression was different between adipose and liver tissues, muscle and liver tissues in both breeds; however, no difference was noted between adipose and muscle tissues. Results from this study indicate that cholesterol content and HMGR mRNA expression are higher in Huai pig tissues suggesting this gene is expressed in a breed- and tissue-dependent manner in pigs. Understanding the causes of variation in HMGR gene expression may provide crucial information about cholesterol biosynthesis. The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is an essential enzyme in cholesterol biosynthesis. To study the expression of HMGR and corresponding cholesterol content in liver, adipose and muscle, six Chinese local breed (Huai pig) and Landrace pigs were selected. The results indicated that significant differences of cholesterol content in adipose (P < 0.01), liver (P < 0.05) and muscle (P < 0.01) tissues were detected between pigs of differing genetic backgrounds. HMGR mRNA expression were noted for adipose, liver and muscle of the two vastly differing genetics. Moreover cholesterol content differed (P < 0.01) among tissues across breed. Likewise, HMGR mRNA expression was different between adipose and liver tissues, muscle and liver tissues in both breeds; however, no difference was noted between adipose and muscle tissues. Results from this study indicate that cholesterol content and HMGR mRNA expression are higher in Huai pig tissues suggesting this gene is expressed in a breed- and tissue-dependent manner in pigs. Understanding the causes of variation in HMGR gene expression may provide crucial information about cholesterol biosynthesis. The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is an essential enzyme in cholesterol biosynthesis. To study the expression of HMGR and corresponding cholesterol content in liver, adipose and muscle, six Chinese local breed (Huai pig) and Landrace pigs were selected. The results indicated that significant differences of cholesterol content in adipose (P < 0.01), liver (P < 0.05) and muscle (P < 0.01) tissues were detected between pigs of differing genetic backgrounds. HMGR mRNA expression were noted for adipose, liver and muscle of the two vastly differing genetics. Moreover cholesterol content differed (P < 0.01) among tissues across breed. Likewise, HMGR mRNA expression was different between adipose and liver tissues, muscle and liver tissues in both breeds; however, no difference was noted between adipose and muscle tissues. Results from this study indicate that cholesterol content and HMGR mRNA expression are higher in Huai pig tissues suggesting this gene is expressed in a breed- and tissue-dependent manner in pigs. Understanding the causes of variation in HMGR gene expression may provide crucial information about cholesterol biosynthesis. [PUBLICATION ABSTRACT] |
Author | Wang, X.-F. Fang, W.-N. Lin, H.-C. Wang, A.-G. Fu, J.-L. Liu, G.-F. |
Author_xml | – sequence: 1 givenname: G.-F. surname: Liu fullname: Liu, G.-F. organization: 1College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China – sequence: 2 givenname: W.-N. surname: Fang fullname: Fang, W.-N. organization: 1College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China – sequence: 3 givenname: H.-C. surname: Lin fullname: Lin, H.-C. organization: 1College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China – sequence: 4 givenname: X.-F. surname: Wang fullname: Wang, X.-F. organization: 4Animal Husbandry & Veterinary Service Station, Beijing, 100107, China – sequence: 5 givenname: J.-L. surname: Fu fullname: Fu, J.-L. email: fujinlian@126.com organization: 1College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China – sequence: 6 givenname: A.-G. surname: Wang fullname: Wang, A.-G. email: agwang@cau.edu.cn organization: 1College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China |
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CitedBy_id | crossref_primary_10_1007_s11033_012_1999_8 crossref_primary_10_1590_1806_9061_2020_1261 crossref_primary_10_3390_foods13050798 crossref_primary_10_1016_j_gene_2011_12_051 |
Cites_doi | 10.1006/bbrc.2000.3100 10.1038/3327 10.1007/s10540-006-9010-3 10.1001/jama.1984.03340270043026 10.1007/BF01534897 10.1172/JCI0216381 10.1093/ajcn/68.3.545 10.1530/rep.1.00657 10.3181/00379727-182-42331 10.1016/S0021-9258(17)39242-6 10.3382/ps.0541075 10.1016/S0309-1740(98)00126-0 10.1016/S0309-1740(03)00012-3 10.1016/S0021-9258(18)37775-5 10.1038/nrd1112 10.1016/j.bbaexp.2003.09.011 10.1016/S0167-4781(02)00624-3 10.1007/BF00284585 10.2174/1568013033483366 10.1042/bj3600363 10.1016/S0021-9258(18)92835-8 10.1056/NEJM199511163332001 10.1016/S1388-1981(00)00134-7 |
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Snippet | The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is an essential enzyme in cholesterol biosynthesis. To study the expression of HMGR and corresponding... |
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SubjectTerms | 3-hydroxy-3-methylglutaryl-CoA reductase cholesterol mRNA expression Physiology and functional biology of systems pig |
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Title | Expression of HMGR and corresponding cholesterol content in tissues of two pig breeds |
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