Expression of HMGR and corresponding cholesterol content in tissues of two pig breeds
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is an essential enzyme in cholesterol biosynthesis. To study the expression of HMGR and corresponding cholesterol content in liver, adipose and muscle, six Chinese local breed (Huai pig) and Landrace pigs were selected. The results indicated that s...
Saved in:
| Published in | Animal (Cambridge, England) Vol. 3; no. 10; pp. 1436 - 1441 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge, UK
Cambridge University Press
01.10.2009
Elsevier Limited Elsevier |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is an essential enzyme in cholesterol biosynthesis. To study the expression of HMGR and corresponding cholesterol content in liver, adipose and muscle, six Chinese local breed (Huai pig) and Landrace pigs were selected. The results indicated that significant differences of cholesterol content in adipose (P < 0.01), liver (P < 0.05) and muscle (P < 0.01) tissues were detected between pigs of differing genetic backgrounds. HMGR mRNA expression were noted for adipose, liver and muscle of the two vastly differing genetics. Moreover cholesterol content differed (P < 0.01) among tissues across breed. Likewise, HMGR mRNA expression was different between adipose and liver tissues, muscle and liver tissues in both breeds; however, no difference was noted between adipose and muscle tissues. Results from this study indicate that cholesterol content and HMGR mRNA expression are higher in Huai pig tissues suggesting this gene is expressed in a breed- and tissue-dependent manner in pigs. Understanding the causes of variation in HMGR gene expression may provide crucial information about cholesterol biosynthesis. |
|---|---|
| AbstractList | The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is an essential enzyme in cholesterol biosynthesis. To study the expression of HMGR and corresponding cholesterol content in liver, adipose and muscle, six Chinese local breed (Huai pig) and Landrace pigs were selected. The results indicated that significant differences of cholesterol content in adipose (P < 0.01), liver (P < 0.05) and muscle (P < 0.01) tissues were detected between pigs of differing genetic backgrounds. HMGR mRNA expression were noted for adipose, liver and muscle of the two vastly differing genetics. Moreover cholesterol content differed (P < 0.01) among tissues across breed. Likewise, HMGR mRNA expression was different between adipose and liver tissues, muscle and liver tissues in both breeds; however, no difference was noted between adipose and muscle tissues. Results from this study indicate that cholesterol content and HMGR mRNA expression are higher in Huai pig tissues suggesting this gene is expressed in a breed- and tissue-dependent manner in pigs. Understanding the causes of variation in HMGR gene expression may provide crucial information about cholesterol biosynthesis. The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is an essential enzyme in cholesterol biosynthesis. To study the expression of HMGR and corresponding cholesterol content in liver, adipose and muscle, six Chinese local breed (Huai pig) and Landrace pigs were selected. The results indicated that significant differences of cholesterol content in adipose (P < 0.01), liver (P < 0.05) and muscle (P < 0.01) tissues were detected between pigs of differing genetic backgrounds. HMGR mRNA expression were noted for adipose, liver and muscle of the two vastly differing genetics. Moreover cholesterol content differed (P < 0.01) among tissues across breed. Likewise, HMGR mRNA expression was different between adipose and liver tissues, muscle and liver tissues in both breeds; however, no difference was noted between adipose and muscle tissues. Results from this study indicate that cholesterol content and HMGR mRNA expression are higher in Huai pig tissues suggesting this gene is expressed in a breed- and tissue-dependent manner in pigs. Understanding the causes of variation in HMGR gene expression may provide crucial information about cholesterol biosynthesis. The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is an essential enzyme in cholesterol biosynthesis. To study the expression of HMGR and corresponding cholesterol content in liver, adipose and muscle, six Chinese local breed (Huai pig) and Landrace pigs were selected. The results indicated that significant differences of cholesterol content in adipose (P < 0.01), liver (P < 0.05) and muscle (P < 0.01) tissues were detected between pigs of differing genetic backgrounds. HMGR mRNA expression were noted for adipose, liver and muscle of the two vastly differing genetics. Moreover cholesterol content differed (P < 0.01) among tissues across breed. Likewise, HMGR mRNA expression was different between adipose and liver tissues, muscle and liver tissues in both breeds; however, no difference was noted between adipose and muscle tissues. Results from this study indicate that cholesterol content and HMGR mRNA expression are higher in Huai pig tissues suggesting this gene is expressed in a breed- and tissue-dependent manner in pigs. Understanding the causes of variation in HMGR gene expression may provide crucial information about cholesterol biosynthesis. [PUBLICATION ABSTRACT] |
| Author | Wang, X.-F. Fang, W.-N. Lin, H.-C. Wang, A.-G. Fu, J.-L. Liu, G.-F. |
| Author_xml | – sequence: 1 givenname: G.-F. surname: Liu fullname: Liu, G.-F. organization: 1College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China – sequence: 2 givenname: W.-N. surname: Fang fullname: Fang, W.-N. organization: 1College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China – sequence: 3 givenname: H.-C. surname: Lin fullname: Lin, H.-C. organization: 1College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China – sequence: 4 givenname: X.-F. surname: Wang fullname: Wang, X.-F. organization: 4Animal Husbandry & Veterinary Service Station, Beijing, 100107, China – sequence: 5 givenname: J.-L. surname: Fu fullname: Fu, J.-L. email: fujinlian@126.com organization: 1College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China – sequence: 6 givenname: A.-G. surname: Wang fullname: Wang, A.-G. email: agwang@cau.edu.cn organization: 1College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22444938$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kU2PFCEQhonZjfuhP8CLIV48jVI03cDRbNbdTdaY7EfijdBQPTLpgRZ6ov57mZ1xYjSeihTv-1DFe0aOYopIyCtg74CBfH8PsgXZADCtNeNt-4ycblsL2fAvR4czwAk5K2XFWKtBiOfkhHMhhG7UKXm8_DFlLCWkSNNArz9d3VEbPXUp1_aUog9xSd3XNGKZMaex3sQZ40xDpHMoZYNla5y_JzqFJe0zoi8vyPFgx4Iv9_WcPH68fLi4Xtx-vrq5-HC7cEKxeYHKO-BSCIbCC6Vda63oG9YOSjFgFrlW3LOubXvVOWw8IA5qaLXrpdND15yTmx3XJ7syUw5rm3-aZIN5aqS8NDbPwY1o0LO-k5577ZyQvrMgpW4cb3qGvJbKertjTTl9q1vNZh2Kw3G0EdOmGF0HBKmYrso3fylXaZNjXdSArt_dwZMIdiKXUykZh8N4wMw2PfNPetXzeg_e9Gv0B8fvuKqg2UPtus_BL_GPp_-L_QVeTqUj |
| CitedBy_id | crossref_primary_10_1007_s11033_012_1999_8 crossref_primary_10_1590_1806_9061_2020_1261 crossref_primary_10_3390_foods13050798 crossref_primary_10_1016_j_gene_2011_12_051 |
| Cites_doi | 10.1006/bbrc.2000.3100 10.1038/3327 10.1007/s10540-006-9010-3 10.1001/jama.1984.03340270043026 10.1007/BF01534897 10.1172/JCI0216381 10.1093/ajcn/68.3.545 10.1530/rep.1.00657 10.3181/00379727-182-42331 10.1016/S0021-9258(17)39242-6 10.3382/ps.0541075 10.1016/S0309-1740(98)00126-0 10.1016/S0309-1740(03)00012-3 10.1016/S0021-9258(18)37775-5 10.1038/nrd1112 10.1016/j.bbaexp.2003.09.011 10.1016/S0167-4781(02)00624-3 10.1007/BF00284585 10.2174/1568013033483366 10.1042/bj3600363 10.1016/S0021-9258(18)92835-8 10.1056/NEJM199511163332001 10.1016/S1388-1981(00)00134-7 |
| ContentType | Journal Article |
| Copyright | Copyright © The Animal Consortium 2009 |
| Copyright_xml | – notice: Copyright © The Animal Consortium 2009 |
| DBID | NPM AAYXX CITATION 3V. 7T5 7T7 7X7 7XB 88A 88E 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P64 PQEST PQQKQ PQUKI PRINS RC3 7X8 DOA |
| DOI | 10.1017/S1751731109990255 |
| DatabaseName | PubMed CrossRef ProQuest Central (Corporate) Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts MEDLINE - Academic Directory of Open Access Journals |
| DatabaseTitle | PubMed CrossRef ProQuest Central Student Technology Research Database ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest Biology Journals (Alumni Edition) ProQuest Central Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection AIDS and Cancer Research Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts Engineering Research Database ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed ProQuest Central Student |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: BENPR name: AUTh Library subscriptions: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Agriculture |
| DocumentTitleAlternate | HMGR and cholesterol content in pig Liu, Fang, Lin, Wang, Fu and Wang |
| EISSN | 1751-732X |
| EndPage | 1441 |
| ExternalDocumentID | oai_doaj_org_article_ed0b67d2d9cc47d6a17793c23b0e2c23 1873514681 10_1017_S1751731109990255 22444938 |
| Genre | Journal Article |
| GroupedDBID | --- -E. .FH 0E1 0R~ 0SF 23M 3V. 4.4 5GY 5VS 74X 74Y 7X7 7~V 88A 88E 8CJ 8FE 8FH 8FI 8FJ 8R4 8R5 AAAZR AABES AABWE AACJH AAEDW AAEED AAFWJ AAGFV AAKTX AARAB AATID AAUKB AAXUO ABBXD ABFBI ABKKG ABKMT ABMWE ABMYL ABQTM ABROB ABUWG ABWCF ABZCX ACBEK ACBMC ACCHT ACGFS ACIMK ACPRK ACQFJ ACQPF ACREK ACUIJ ACUYZ ACWGA ACZBM ACZUX ADBBV ADFEC ADGEJ ADOCW ADOVH AEBAK AEHGV AENEX AENGE AEXQZ AEYYC AFFUJ AFKQG AFKRA AFLOS AFLVW AFPKN AFRAH AFUTZ AGOOT AHLTW AHMBA AHQXX AIGNW AIHIV AIOIP AISIE AJ7 AJCYY AJPFC AJQAS AKRWK ALMA_UNASSIGNED_HOLDINGS ALWZO AMRAJ ANPSP ARABE ATUCA AUXHV AZGZS BBLKV BBNVY BENPR BGHMG BHPHI BMAJL BPHCQ BRIRG BVXVI C0O CAG CBIIA CCPQU CFAFE COF CS3 D1J DC4 DIK DOHLZ EBS EJD F5P FDB FYUFA GROUPED_DOAJ HCIFZ HG- HMCUK HST HZ~ I.6 IH6 IOEEP IS6 I~P J36 J38 J3A JHPGK JKPOH JQKCU JVRFK KCGVB KFECR L98 LK8 LW7 M-V M0L M1P M7P NIKVX O9- PQQKQ PROAC PSQYO Q2X RAMDC RCA RR0 S6- S6U SAAAG SY4 T9M TR2 UKHRP UT1 UU6 WQ3 WXY WYP Y6R ZYDXJ ~KM AAHBH AALRI ADVLN AFJKZ AITUG ALIPV CTKSN NPM AAYXX CITATION 7T5 7T7 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. P64 PQEST PQUKI PRINS RC3 7X8 |
| ID | FETCH-LOGICAL-c480t-e8dc127440e4d489c5aa4b305f88010ae2982d0655b86ce3d1eef8f59cb7c9f63 |
| IEDL.DBID | BENPR |
| ISSN | 1751-7311 |
| IngestDate | Tue Oct 22 15:09:28 EDT 2024 Fri Aug 16 04:18:57 EDT 2024 Thu Oct 10 16:52:45 EDT 2024 Thu Sep 26 19:10:13 EDT 2024 Sat Sep 28 07:49:43 EDT 2024 Wed Mar 13 05:51:44 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Keywords | cholesterol 3-hydroxy-3-methylglutaryl-CoA reductase mRNA expression pig |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c480t-e8dc127440e4d489c5aa4b305f88010ae2982d0655b86ce3d1eef8f59cb7c9f63 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://doaj.org/article/ed0b67d2d9cc47d6a17793c23b0e2c23 |
| PMID | 22444938 |
| PQID | 197316109 |
| PQPubID | 39409 |
| PageCount | 6 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_ed0b67d2d9cc47d6a17793c23b0e2c23 proquest_miscellaneous_948917809 proquest_journals_197316109 crossref_primary_10_1017_S1751731109990255 pubmed_primary_22444938 cambridge_journals_10_1017_S1751731109990255 |
| PublicationCentury | 2000 |
| PublicationDate | 2009-10-01 |
| PublicationDateYYYYMMDD | 2009-10-01 |
| PublicationDate_xml | – month: 10 year: 2009 text: 2009-10-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Cambridge, UK |
| PublicationPlace_xml | – name: Cambridge, UK – name: England – name: Kidlington |
| PublicationTitle | Animal (Cambridge, England) |
| PublicationTitleAlternate | Animal |
| PublicationYear | 2009 |
| Publisher | Cambridge University Press Elsevier Limited Elsevier |
| Publisher_xml | – name: Cambridge University Press – name: Elsevier Limited – name: Elsevier |
| References | Lee (10.1017/S1751731109990255_bib0012) 1986 Myant (10.1017/S1751731109990255_bib0016) 1990; 66 Sato (10.1017/S1751731109990255_bib0020) 2003; 1630 Tabas (10.1017/S1751731109990255_bib0026) 2002; 110 Ha (10.1017/S1751731109990255_bib007) 2003; 1625 Istvan (10.1017/S1751731109990255_bib0010) 2000; 1529 Lord (10.1017/S1751731109990255_bib0014) 2006; 131 Simonet (10.1017/S1751731109990255_bib0023) 1988; 263 Leveille (10.1017/S1751731109990255_bib0013) 1975; 54 Harris (10.1017/S1751731109990255_bib008) 2004; 66 Luskey (10.1017/S1751731109990255_bib0015) 1985; 260 Fink (10.1017/S1751731109990255_bib006) 1998; 4 Sundaresan (10.1017/S1751731109990255_bib0025) 1989; 15 Tobert (10.1017/S1751731109990255_bib0028) 2003; 2 Duckworth (10.1017/S1751731109990255_bib004) 1991; 266 Van (10.1017/S1751731109990255_bib0030) 1991; 285 (10.1017/S1751731109990255_bib0021) 1994; 344 Jiang (10.1017/S1751731109990255_bib0011) 2006; 26 Pond (10.1017/S1751731109990255_bib0018) 1986; 182 10.1017/S1751731109990255_bib0031 Ness (10.1017/S1751731109990255_bib0017) 2003; 3 Dodds (10.1017/S1751731109990255_bib003) 1982; 41 Rasmusseen (10.1017/S1751731109990255_bib0019) 2001; 360 Favy (10.1017/S1751731109990255_bib005) 2000; 274 Shepherd (10.1017/S1751731109990255_bib0022) 1995; 333 10.1017/S1751731109990255_bib0029 Stanton (10.1017/S1751731109990255_bib0024) 1986 (10.1017/S1751731109990255_bib0027) 1984; 251 Baum (10.1017/S1751731109990255_bib001) 1998; 68 Humphries (10.1017/S1751731109990255_bib009) 1985; 71 Dorado (10.1017/S1751731109990255_bib002) 1999; 51 |
| References_xml | – volume: 274 start-page: 73 year: 2000 ident: 10.1017/S1751731109990255_bib005 article-title: Real-time PCR quantification of full-length and exon 11 spliced BRCA1 transcripts in human breast cancer cell lines publication-title: Biochemical and Biophysical Research Communications doi: 10.1006/bbrc.2000.3100 contributor: fullname: Favy – volume: 4 start-page: 1329 year: 1998 ident: 10.1017/S1751731109990255_bib006 article-title: Real-time quantitative RT-PCR after laser-assisted cell picking publication-title: Nature Medicine doi: 10.1038/3327 contributor: fullname: Fink – volume: 26 start-page: 171 year: 2006 ident: 10.1017/S1751731109990255_bib0011 article-title: Molecular cloning of a HMG-CoA reductase gene from Eucommia ulmoides Oliver publication-title: Bioscience Reports doi: 10.1007/s10540-006-9010-3 contributor: fullname: Jiang – volume: 251 start-page: 365 year: 1984 ident: 10.1017/S1751731109990255_bib0027 article-title: II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering publication-title: The Journal of American Medical Association doi: 10.1001/jama.1984.03340270043026 – volume: 15 start-page: 465 year: 1989 ident: 10.1017/S1751731109990255_bib0025 article-title: Genes for HMG-CoA reductase and serotonin 1a receptor are on mouse chromosome 13 publication-title: Somatic Cell and Molecular Genetics doi: 10.1007/BF01534897 contributor: fullname: Sundaresan – ident: 10.1017/S1751731109990255_bib0031 – volume: 110 start-page: 583 year: 2002 ident: 10.1017/S1751731109990255_bib0026 article-title: Cholesterol in health and disease publication-title: The Journal of Clinical Investigation doi: 10.1172/JCI0216381 contributor: fullname: Tabas – volume: 68 start-page: 545 year: 1998 ident: 10.1017/S1751731109990255_bib001 article-title: Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density-lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women publication-title: The American journal of Clinical Nutrition doi: 10.1093/ajcn/68.3.545 contributor: fullname: Baum – volume: 131 start-page: 929 year: 2006 ident: 10.1017/S1751731109990255_bib0014 article-title: Modulation of peroxisome proliferator-activated receptord and ?transcripts in swine endometrial tissue during early gestation publication-title: Reproduction doi: 10.1530/rep.1.00657 contributor: fullname: Lord – volume: 182 start-page: 221 year: 1986 ident: 10.1017/S1751731109990255_bib0018 article-title: Heritability of plasma cholesterol and triglyceride concentrations in swine publication-title: Proceedings of the Society for Experimental Biology and Medicine doi: 10.3181/00379727-182-42331 contributor: fullname: Pond – year: 1986 ident: 10.1017/S1751731109990255_bib0024 contributor: fullname: Stanton – volume: 260 start-page: 10271 year: 1985 ident: 10.1017/S1751731109990255_bib0015 article-title: Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation publication-title: The Journal of Biological Chemistry doi: 10.1016/S0021-9258(17)39242-6 contributor: fullname: Luskey – volume: 54 start-page: 1075 year: 1975 ident: 10.1017/S1751731109990255_bib0013 article-title: Lipid biosynthesis in the chick. A consideration of site of synthesis, influence of diet and possible regulatory mechanisms publication-title: Poultry Science doi: 10.3382/ps.0541075 contributor: fullname: Leveille – volume: 285 start-page: 417 year: 1991 ident: 10.1017/S1751731109990255_bib0030 article-title: Lipoprotein structure and metabolism during progression and regression of atherosclerosis in pigs fed with fish oil-derived fatty acids publication-title: Advances in Experimental Medicine and Biology contributor: fullname: Van – volume: 66 start-page: 1015 year: 1990 ident: 10.1017/S1751731109990255_bib0016 article-title: Current approaches to the genetics of coronary heart disease (CHD) including an account of work done at Hammersmith Hospital publication-title: Bollettino della Società italiana di biologia sperimentale contributor: fullname: Myant – volume: 51 start-page: 321 year: 1999 ident: 10.1017/S1751731109990255_bib002 article-title: Cholesterol and fat contents of Spanish commercial pork cuts publication-title: Meat Science doi: 10.1016/S0309-1740(98)00126-0 contributor: fullname: Dorado – ident: 10.1017/S1751731109990255_bib0029 – volume: 66 start-page: 55 year: 2004 ident: 10.1017/S1751731109990255_bib008 article-title: Evaluation of fat sources on cholesterol and lipoproteins using pigs selected for high or low serum cholesterol publication-title: Meat Science doi: 10.1016/S0309-1740(03)00012-3 contributor: fullname: Harris – volume: 263 start-page: 12448 year: 1988 ident: 10.1017/S1751731109990255_bib0023 article-title: Transcriptional and post-transcriptional regulation of rat hepatic 3-hydroxy-3-methylglutaryl-CoA reductase by thyroid hormones publication-title: The Journal of Biological Chemistry doi: 10.1016/S0021-9258(18)37775-5 contributor: fullname: Simonet – volume: 2 start-page: 517 year: 2003 ident: 10.1017/S1751731109990255_bib0028 article-title: Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors publication-title: Nature Reviews Drug Discovery doi: 10.1038/nrd1112 contributor: fullname: Tobert – volume: 344 start-page: 1383 year: 1994 ident: 10.1017/S1751731109990255_bib0021 article-title: Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) publication-title: Lancet – volume: 1630 start-page: 96 year: 2003 ident: 10.1017/S1751731109990255_bib0020 article-title: Changes in mRNA expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7 alpha-hydroxylase in chickens publication-title: Biochimica Biophysica Acta doi: 10.1016/j.bbaexp.2003.09.011 contributor: fullname: Sato – volume: 1625 start-page: 253 year: 2003 ident: 10.1017/S1751731109990255_bib007 article-title: Molecular characterization of three 3-hydroxy-3-methylglutaryl-CoA reductase genes including pathogen-induced Hmg2 from pepper (Capsicum annuum) publication-title: Biochima Biophysica Acta doi: 10.1016/S0167-4781(02)00624-3 contributor: fullname: Ha – volume: 71 start-page: 254 year: 1985 ident: 10.1017/S1751731109990255_bib009 article-title: The isolation, characterization, and chromosomal assignment of the gene for human hydroxyl 3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) publication-title: Human Genetics doi: 10.1007/BF00284585 contributor: fullname: Humphries – volume: 3 start-page: 219 year: 2003 ident: 10.1017/S1751731109990255_bib0017 article-title: Physiological and pharmacological regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase publication-title: Current Medicinal Chemistry-Imunology, Endocrine & Metabolic Agents doi: 10.2174/1568013033483366 contributor: fullname: Ness – volume: 360 start-page: 363 year: 2001 ident: 10.1017/S1751731109990255_bib0019 article-title: Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells publication-title: The Biochemical Journal doi: 10.1042/bj3600363 contributor: fullname: Rasmusseen – volume: 266 start-page: 9413 year: 1991 ident: 10.1017/S1751731109990255_bib004 article-title: Effect of hydrophobic bile acid on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and mRNA levels in the rat publication-title: The Journal of Biological Chemistry doi: 10.1016/S0021-9258(18)92835-8 contributor: fullname: Duckworth – volume: 333 start-page: 1301 year: 1995 ident: 10.1017/S1751731109990255_bib0022 article-title: Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group publication-title: The New England Journal of Medicine doi: 10.1056/NEJM199511163332001 contributor: fullname: Shepherd – volume: 41 start-page: 247 year: 1982 ident: 10.1017/S1751731109990255_bib003 article-title: The pig model for biomedical research publication-title: Federation Proceeding contributor: fullname: Dodds – volume: 1529 start-page: 9 year: 2000 ident: 10.1017/S1751731109990255_bib0010 article-title: The structure of the catalytic portion of human HMG-CoA reductase publication-title: Biochimica Biophysica Acta doi: 10.1016/S1388-1981(00)00134-7 contributor: fullname: Istvan – year: 1986 ident: 10.1017/S1751731109990255_bib0012 contributor: fullname: Lee |
| SSID | ssj0059144 |
| Score | 1.904807 |
| Snippet | The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is an essential enzyme in cholesterol biosynthesis. To study the expression of HMGR and corresponding... |
| SourceID | doaj proquest crossref pubmed cambridge |
| SourceType | Open Website Aggregation Database Index Database Publisher |
| StartPage | 1436 |
| SubjectTerms | 3-hydroxy-3-methylglutaryl-CoA reductase cholesterol mRNA expression Physiology and functional biology of systems pig |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NS-VADB8WT7sHcT_U58cyB0-LxU47nY-jiu5DcA_LPvBWZiapCNI-fBX98zcz7Xu8RdTLngrTlIYkk2RI5hfGjkAbCsqlJO_nXCwz-szlqsnASKCIgyBEvCh8_UtNZ_LqprpZG_UVe8IGeOBBcCcIuVcaCrAhSA3KCU0mFYrS51jQI3lfUS0PU4MPrqxIY1wpNopMl0Is65kRLDouxrWYG8WMeh1V4Z_olED8X888UwS63GKbY-rITweWP7MP2H5hn05vH0b4DPzKZhfPY2Nry7uGT69__uauBR7SDI55l66w8OjxEkBCd89jqzrFHX7X8j7pYBE_7J86Pr-75XReRlh8Y7PLiz_n02wcnJAFafI-QwNBJOg_lCCNDZVz0tPObmi3itxhYU0BlHxU3qiAJQjExjSVDV4H26hym220XYu7jJcRAI7OSKQ5LTFHoxqBlWqUB-sRYMKOV8KrR_Nf1EPrmK5fyHrCfizlW88HOI23iM-iBlaEEQk7LZB91KN91O_Zx4TtL_W3xl8a2EU_mjC-ekv7KhZLXIvd46K2JDehTSTZGbS-4oOyHiltafb-B3_77GMqUKX-wAO20T884iHlOb3_nkz6L7GG9Kw priority: 102 providerName: Directory of Open Access Journals |
| Title | Expression of HMGR and corresponding cholesterol content in tissues of two pig breeds |
| URI | https://www.cambridge.org/core/product/identifier/S1751731109990255/type/journal_article https://www.ncbi.nlm.nih.gov/pubmed/22444938 https://www.proquest.com/docview/197316109 https://search.proquest.com/docview/948917809 https://doaj.org/article/ed0b67d2d9cc47d6a17793c23b0e2c23 |
| Volume | 3 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9swEBdr87I9lH0vbRf0sKcxM8uW9fE00pIurLSMsLC8GUs6h8Kw09il-_OnU-TQMdYngywJcaf7kO70O0I-OKm8Uc65135VhWFGk1SpqBOnuPMWBxxj-FD46lrMl_zbqljF3JwuplUOOjEoatdavCP_zEKNJZbqL5vbBItGYXA1VtA4IKOMcYzSjs5m198XgyouNAvVXL2JZIkfzoawJmJGYyO2oYuEjvVDcIW_jFTA8v-_AxoM0cVzchQ9SDrdsfwFeQLNS_Jsut5GFA14RZaz3zG_taFtTedXXxe0ahy1oRTHpg0vWSgqvoCT0P6imLHuzQ-9aWgfWNHhwP6-pZubNfXHZnDda7K8mP04nyexfkJiuUr7BJSzLCAAAndcaVtUFTdewGsvtCytINMqc94HKYwSFnLHAGpVF9oaaXUt8jfksGkbeEdojjhw_qjkGSg5pKBEzaAQtTBOG3BuTD7tiVdGKejKXQaZLP-h9Zh8HOhbbnaoGo91PkMO7DsiIHZoaLfrMspXCS41QrrMaWu5dKJi0msem-Umhcx_xuRk4N-D9Q17akzo_q8XL4yZVA20d12pPd2YVNjl7Y7r-3V454dznavjR6c-IU9DACrk_52Sw357B--9H9ObCTmQKzkho-nl4uflJO7dSbgV-AMhBfA3 |
| link.rule.ids | 315,786,790,870,2115,12083,21416,27955,27956,31752,31753,33777,33778,43343,43838 |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagHKAHxLtLefjACRERJ44fJ1SqlgW6PaCutLfIj8mqEkqWTSr4-Xi8TlSE2lMkZxxZM56HM-NvCHnnpQpOueTB-hmDaUabmVw0mVfcB48DnjG8KLw4F_Ml_7aqVqk2p09llaNNjIbadw7_kX9ksccSy_Wnza8Mm0ZhcjV10LhL7vGy5LjN5Wo6b1WaxV6uwUGyLExmY1ITEaNxEMcwQMKw-jq0wj8uKiL53xx-Rjd0-og8TPEjPdoJ_DG5A-0Tsn-03iYMDXhKlid_UnVrS7uGzhdfflDTeupiI45NF--xUDR7ESWh-0mxXj04H3rZ0iEKoseJw--Obi7XNByawffPyPL05OJ4nqXuCZnjKh8yUN6xiP8H3HOlXWUMt0G9m6CyLDdQaFX4EIFUVgkHpWcAjWoq7ax0uhHlc7LXdi0cEFoiClw4KAXxSQ45KNEwqEQjrNcWvJ-RDxPz6qQDfb2rH5P1f7yekfcjf-vNDlPjNuLPKIGJEOGw40C3XddJu2rwuRXSF147x6UXhslgd1xR2hyK8JiRw1F-19Y37qgZodPboFyYMTEtdFd9rQPfmFRI8mIn9WkdIfThXJfq5a2ffkvuzy8WZ_XZ1_Pvh-RBTEXFSsBXZG_YXsHrENEM9k3ct38BtFDuPw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Expression+of+HMGR+and+corresponding+cholesterol+content+in+tissues+of+two+pig+breeds&rft.jtitle=Animal+%28Cambridge%2C+England%29&rft.au=Liu%2C+G.-F.&rft.au=Fang%2C+W.-N.&rft.au=Lin%2C+H.-C.&rft.au=Wang%2C+X.-F.&rft.date=2009-10-01&rft.issn=1751-7311&rft.volume=3&rft.issue=10&rft.spage=1436&rft.epage=1441&rft_id=info:doi/10.1017%2FS1751731109990255&rft.externalDBID=n%2Fa&rft.externalDocID=10_1017_S1751731109990255 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1751-7311&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1751-7311&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1751-7311&client=summon |