Evaluation of Autonomic Nervous System Dysfunction in Childhood Obesity and Prader–Willi Syndrome

The autonomic nervous system (ANS) may play a role in the distribution of body fat and the development of obesity and its complications. Features of individuals with Prader–Willi syndrome (PWS) impacted by PWS molecular genetic classes suggest alterations in ANS function; however, these have been ra...

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Published inInternational journal of molecular sciences Vol. 24; no. 9; p. 8013
Main Authors Richer, Lawrence P., Tan, Qiming, Butler, Merlin G., Avedzi, Hayford M., DeLorey, Darren S., Peng, Ye, Tun, Hein M., Sharma, Arya M., Ainsley, Steven, Orsso, Camila E., Triador, Lucila, Freemark, Michael, Haqq, Andrea M.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 28.04.2023
MDPI
Subjects
Appetite
Autonomic Nervous System
Blood pressure
Body Mass Index
Case-Control Studies
Child
Childhood
Eating behavior
Female
Food
Gene expression
Heart
Heart beat
Heart rate
Hormones
Humans
Hypothalamus
Male
Metabolism
Nervous system
Obesity
Obesity in children
Pediatric Obesity - complications
Peptides
Prader-Willi Syndrome - complications
Sleep
Weight control
Alberta
autonomic nervous system (ANS)
genetics
Prader–Willi syndrome (PWS)
childhood obesity
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Abstract The autonomic nervous system (ANS) may play a role in the distribution of body fat and the development of obesity and its complications. Features of individuals with Prader–Willi syndrome (PWS) impacted by PWS molecular genetic classes suggest alterations in ANS function; however, these have been rarely studied and presented with conflicting results. The aim of this study was to investigate if the ANS function is altered in PWS. In this case-control study, we assessed ANS function in 20 subjects with PWS (6 males/14 females; median age 10.5 years) and 27 body mass index (BMI) z-score-matched controls (19 males/8 females; median age 12.8 years). Standardized non-invasive measures of cardiac baroreflex function, heart rate, blood pressure, heart rate variability, quantitative sudomotor axon reflex tests, and a symptom questionnaire were completed. The increase in heart rate in response to head-up tilt testing was blunted (p < 0.01) in PWS compared to controls. Besides a lower heart rate ratio with Valsalva in PWS (p < 0.01), no significant differences were observed in other measures of cardiac function or sweat production. Findings suggest possible altered sympathetic function in PWS.
AbstractList The autonomic nervous system (ANS) may play a role in the distribution of body fat and the development of obesity and its complications. Features of individuals with Prader-Willi syndrome (PWS) impacted by PWS molecular genetic classes suggest alterations in ANS function; however, these have been rarely studied and presented with conflicting results. The aim of this study was to investigate if the ANS function is altered in PWS. In this case-control study, we assessed ANS function in 20 subjects with PWS (6 males/14 females; median age 10.5 years) and 27 body mass index (BMI) z-score-matched controls (19 males/8 females; median age 12.8 years). Standardized non-invasive measures of cardiac baroreflex function, heart rate, blood pressure, heart rate variability, quantitative sudomotor axon reflex tests, and a symptom questionnaire were completed. The increase in heart rate in response to head-up tilt testing was blunted ( < 0.01) in PWS compared to controls. Besides a lower heart rate ratio with Valsalva in PWS ( < 0.01), no significant differences were observed in other measures of cardiac function or sweat production. Findings suggest possible altered sympathetic function in PWS.
The autonomic nervous system (ANS) may play a role in the distribution of body fat and the development of obesity and its complications. Features of individuals with Prader–Willi syndrome (PWS) impacted by PWS molecular genetic classes suggest alterations in ANS function; however, these have been rarely studied and presented with conflicting results. The aim of this study was to investigate if the ANS function is altered in PWS. In this case-control study, we assessed ANS function in 20 subjects with PWS (6 males/14 females; median age 10.5 years) and 27 body mass index (BMI) z-score-matched controls (19 males/8 females; median age 12.8 years). Standardized non-invasive measures of cardiac baroreflex function, heart rate, blood pressure, heart rate variability, quantitative sudomotor axon reflex tests, and a symptom questionnaire were completed. The increase in heart rate in response to head-up tilt testing was blunted (p < 0.01) in PWS compared to controls. Besides a lower heart rate ratio with Valsalva in PWS (p < 0.01), no significant differences were observed in other measures of cardiac function or sweat production. Findings suggest possible altered sympathetic function in PWS.
The autonomic nervous system (ANS) may play a role in the distribution of body fat and the development of obesity and its complications. Features of individuals with Prader-Willi syndrome (PWS) impacted by PWS molecular genetic classes suggest alterations in ANS function; however, these have been rarely studied and presented with conflicting results. The aim of this study was to investigate if the ANS function is altered in PWS. In this case-control study, we assessed ANS function in 20 subjects with PWS (6 males/14 females; median age 10.5 years) and 27 body mass index (BMI) z-score-matched controls (19 males/8 females; median age 12.8 years). Standardized non-invasive measures of cardiac baroreflex function, heart rate, blood pressure, heart rate variability, quantitative sudomotor axon reflex tests, and a symptom questionnaire were completed. The increase in heart rate in response to head-up tilt testing was blunted (p < 0.01) in PWS compared to controls. Besides a lower heart rate ratio with Valsalva in PWS (p < 0.01), no significant differences were observed in other measures of cardiac function or sweat production. Findings suggest possible altered sympathetic function in PWS.The autonomic nervous system (ANS) may play a role in the distribution of body fat and the development of obesity and its complications. Features of individuals with Prader-Willi syndrome (PWS) impacted by PWS molecular genetic classes suggest alterations in ANS function; however, these have been rarely studied and presented with conflicting results. The aim of this study was to investigate if the ANS function is altered in PWS. In this case-control study, we assessed ANS function in 20 subjects with PWS (6 males/14 females; median age 10.5 years) and 27 body mass index (BMI) z-score-matched controls (19 males/8 females; median age 12.8 years). Standardized non-invasive measures of cardiac baroreflex function, heart rate, blood pressure, heart rate variability, quantitative sudomotor axon reflex tests, and a symptom questionnaire were completed. The increase in heart rate in response to head-up tilt testing was blunted (p < 0.01) in PWS compared to controls. Besides a lower heart rate ratio with Valsalva in PWS (p < 0.01), no significant differences were observed in other measures of cardiac function or sweat production. Findings suggest possible altered sympathetic function in PWS.
The autonomic nervous system (ANS) may play a role in the distribution of body fat and the development of obesity and its complications. Features of individuals with Prader–Willi syndrome (PWS) impacted by PWS molecular genetic classes suggest alterations in ANS function; however, these have been rarely studied and presented with conflicting results. The aim of this study was to investigate if the ANS function is altered in PWS. In this case-control study, we assessed ANS function in 20 subjects with PWS (6 males/14 females; median age 10.5 years) and 27 body mass index (BMI) z-score-matched controls (19 males/8 females; median age 12.8 years). Standardized non-invasive measures of cardiac baroreflex function, heart rate, blood pressure, heart rate variability, quantitative sudomotor axon reflex tests, and a symptom questionnaire were completed. The increase in heart rate in response to head-up tilt testing was blunted ( p < 0.01) in PWS compared to controls. Besides a lower heart rate ratio with Valsalva in PWS ( p < 0.01), no significant differences were observed in other measures of cardiac function or sweat production. Findings suggest possible altered sympathetic function in PWS.
Audience Academic
Author Richer, Lawrence P.
Tun, Hein M.
Peng, Ye
Ainsley, Steven
Triador, Lucila
Haqq, Andrea M.
Freemark, Michael
Butler, Merlin G.
DeLorey, Darren S.
Sharma, Arya M.
Tan, Qiming
Avedzi, Hayford M.
Orsso, Camila E.
AuthorAffiliation 4 JC School of Public Health, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China
5 Department of Medicine, University of Alberta, Edmonton, AB T6G 2R3, Canada
1 Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada
7 Division of Pediatric Endocrinology, Duke University Medical Center, Durham, NC 27705, USA
6 Department of Agricultural Food & Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada
2 Departments of Psychiatry & Behavioral Sciences and Pediatrics, Kansas University Medical Center, Kansas City, KS 66160, USA
3 Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB T6G 2R3, Canada
AuthorAffiliation_xml – name: 5 Department of Medicine, University of Alberta, Edmonton, AB T6G 2R3, Canada
– name: 7 Division of Pediatric Endocrinology, Duke University Medical Center, Durham, NC 27705, USA
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– name: 4 JC School of Public Health, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China
– name: 6 Department of Agricultural Food & Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada
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CitedBy_id crossref_primary_10_3390_pediatric16010013
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crossref_primary_10_1016_j_ijpsycho_2024_112429
crossref_primary_10_1007_s10286_024_01083_8
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2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Keywords autonomic nervous system (ANS)
genetics
Prader–Willi syndrome (PWS)
childhood obesity
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Snippet The autonomic nervous system (ANS) may play a role in the distribution of body fat and the development of obesity and its complications. Features of...
SourceID pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 8013
SubjectTerms Appetite
Autonomic Nervous System
Blood pressure
Body Mass Index
Case-Control Studies
Child
Childhood
Eating behavior
Female
Food
Gene expression
Heart
Heart beat
Heart rate
Hormones
Humans
Hypothalamus
Male
Metabolism
Nervous system
Obesity
Obesity in children
Pediatric Obesity - complications
Peptides
Prader-Willi Syndrome - complications
Sleep
Weight control
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Title Evaluation of Autonomic Nervous System Dysfunction in Childhood Obesity and Prader–Willi Syndrome
URI https://www.ncbi.nlm.nih.gov/pubmed/37175718
https://www.proquest.com/docview/2812611936
https://www.proquest.com/docview/2813563410
https://pubmed.ncbi.nlm.nih.gov/PMC10179129
Volume 24
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