Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index

• Published in: Journal of lipid research Vol. 43; no. 1; pp. 51 - 58
• Main Authors: Ledmyr, Helena, Karpe, Fredrik, Lundahl, Björn, McKinnon, Margaret, Skoglund-Andersson, Camilla, Ehrenborg, Ewa
• Format: Journal Article
• Language: English
• Published: United States Elsevier 01.01.2002
• Subjects: Alleles; Apolipoproteins B - blood; Body Mass Index; cardiovascular disease; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cholesterol - blood; Cohort Studies; Gene Frequency; Genetic Variation; Genotype; Humans; Insulin - blood; LDL cholesterol; Linkage Disequilibrium; Lipoproteins, LDL - blood; Male; microsomal triglyceride transfer protein; Middle Aged; Mutation, Missense; Point Mutation; polymorphism; Polymorphism, Genetic; Promoter Regions, Genetic; United Kingdom - ethnology

The microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins from liver and intestine. We set out to study the phenotypic modulation of all common genetic variants in the MTP gene. In addition, we aimed at characteri...