Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies

• Published in: The Lancet (British edition) Vol. 370; no. 9596; pp. 1422 - 1431
• Main Authors: Wenzel, Sally, Wilbraham, Darren, Fuller, Rick, Getz, Elise Burmeister, Longphre, Malinda
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 20.10.2007; Elsevier Limited
• Subjects: Adult; Anti-Asthmatic Agents - adverse effects; Anti-Asthmatic Agents - therapeutic use; Asthma; Asthma - drug therapy; Bronchial Provocation Tests - methods; Cells; Clinical medicine; Clinical trials; Cytokines; Data analysis; Double-Blind Method; Drugs; Eczema; Female; Forced Expiratory Volume - drug effects; Humans; Inhalation; Interleukin-4 - analogs & derivatives; Interleukin-4 - metabolism; Internal Medicine; Male; Receptors, Interleukin-4 - antagonists & inhibitors; Skin diseases

Increases in T helper (Th) 2 cytokine concentrations have been seen in atopic asthma, with interleukin 4 and interleukin 13 thought to have a role in the physiological response to allergen challenge. Our aim was to assess the therapeutic effect of pitrakinra, an interleukin-4 variant that targets al...