Low genetic diversity of 'Plasmodium vivax' circumsporozoite surface protein in clinical isolates from southern Thailand

The genetic diversity within the circumsporozoite surface protein (PvCSP) of 'Plasmodium vivax', the predominant malaria species in Thailand, is primarily observed in the northwestern region along the Thailand-Myanmar border. However, asP. viva cases shift to southern provinces, particular...

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Published inTropical medicine and infectious disease Vol. 9; no. 5; pp. 1 - 13
Main Authors Khulmanee, Tachin, Thita, Thanyapit, Kritsiriwutinan, Kanyanan, Boonyuen, Usa, Saai, Aminoh, Inkabjan, Kanjana, Chakrabarti, Rimi, Rathod, Pradipsinh K, Krudsood, Srivicha, Mungthin, Mathirut, Patrapuvich, Rapatbhorn
Format Journal Article
LanguageEnglish
Published Basel, Switzerland MDPI 01.05.2024
MDPI AG
Subjects
circumsporozoite surface protein
Evaluation
Genetic diversity
Infections
Malaria
Malaria vaccine
Plasmodium vivax
Polymerase chain reaction
Polymorphism
Proteins
Thailand
Treatment
Myanmar (Burma)
Thailand
United States > US
Germany
Plasmodium vivax
circumsporozoite surface protein
Thailand
malaria
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Abstract The genetic diversity within the circumsporozoite surface protein (PvCSP) of 'Plasmodium vivax', the predominant malaria species in Thailand, is primarily observed in the northwestern region along the Thailand-Myanmar border. However, asP. viva cases shift to southern provinces, particularly Yala Province near the Thailand-Malaysia border, PvCSP diversity remains understudied. Between 2018 and 2020, 89P. viva isolates were collected in Yala Province, a significant malaria hotspot. Employing polymerase chain reaction amplification, restriction fragment length polymor- phism (PCR-RFLP), and DNA sequencing, the gene encoding PvCSP (Pvcsp) was analyzed. All Yala P. vivax isolates belonged to the VK210 type, distinct from strains in the western region near the Myanmar border. The central repeat region of Pvcsp revealed two common peptide repeat motifs-GDRADGQPA and GDRAAGQPA-across all southern isolates. Sequence analysis identified two subtypes, with S1 more prevalent (92%) than S2 (8%). This study underscores the limited diversity of VK210 variants of 'P. vivax' populations in southern Thailand. These baseline findings facilitate monitoring for potential new parasite variants, aiding in the future control and management of 'P. vivax' in the region.
AbstractList The genetic diversity within the circumsporozoite surface protein (PvCSP) of Plasmodium vivax, the predominant malaria species in Thailand, is primarily observed in the northwestern region along the Thailand–Myanmar border. However, as P. vivax cases shift to southern provinces, particularly Yala Province near the Thailand–Malaysia border, PvCSP diversity remains understudied. Between 2018 and 2020, 89 P. vivax isolates were collected in Yala Province, a significant malaria hotspot. Employing polymerase chain reaction amplification, restriction fragment length polymorphism (PCR-RFLP), and DNA sequencing, the gene encoding PvCSP (Pvcsp) was analyzed. All Yala P. vivax isolates belonged to the VK210 type, distinct from strains in the western region near the Myanmar border. The central repeat region of Pvcsp revealed two common peptide repeat motifs—GDRADGQPA and GDRAAGQPA—across all southern isolates. Sequence analysis identified two subtypes, with S1 more prevalent (92%) than S2 (8%). This study underscores the limited diversity of VK210 variants of P. vivax populations in southern Thailand. These baseline findings facilitate monitoring for potential new parasite variants, aiding in the future control and management of P. vivax in the region.
The genetic diversity within the circumsporozoite surface protein (PvCSP) of , the predominant malaria species in Thailand, is primarily observed in the northwestern region along the Thailand-Myanmar border. However, as cases shift to southern provinces, particularly Yala Province near the Thailand-Malaysia border, PvCSP diversity remains understudied. Between 2018 and 2020, 89 isolates were collected in Yala Province, a significant malaria hotspot. Employing polymerase chain reaction amplification, restriction fragment length polymorphism (PCR-RFLP), and DNA sequencing, the gene encoding PvCSP ( ) was analyzed. All Yala isolates belonged to the VK210 type, distinct from strains in the western region near the Myanmar border. The central repeat region of revealed two common peptide repeat motifs-GDRADGQPA and GDRAAGQPA-across all southern isolates. Sequence analysis identified two subtypes, with S1 more prevalent (92%) than S2 (8%). This study underscores the limited diversity of VK210 variants of populations in southern Thailand. These baseline findings facilitate monitoring for potential new parasite variants, aiding in the future control and management of in the region.
The genetic diversity within the circumsporozoite surface protein (PvCSP) of 'Plasmodium vivax', the predominant malaria species in Thailand, is primarily observed in the northwestern region along the Thailand-Myanmar border. However, asP. viva cases shift to southern provinces, particularly Yala Province near the Thailand-Malaysia border, PvCSP diversity remains understudied. Between 2018 and 2020, 89P. viva isolates were collected in Yala Province, a significant malaria hotspot. Employing polymerase chain reaction amplification, restriction fragment length polymor- phism (PCR-RFLP), and DNA sequencing, the gene encoding PvCSP (Pvcsp) was analyzed. All Yala P. vivax isolates belonged to the VK210 type, distinct from strains in the western region near the Myanmar border. The central repeat region of Pvcsp revealed two common peptide repeat motifs-GDRADGQPA and GDRAAGQPA-across all southern isolates. Sequence analysis identified two subtypes, with S1 more prevalent (92%) than S2 (8%). This study underscores the limited diversity of VK210 variants of 'P. vivax' populations in southern Thailand. These baseline findings facilitate monitoring for potential new parasite variants, aiding in the future control and management of 'P. vivax' in the region.
Author Srivicha Krudsood
Aminoh Saai
Tachin Khulmanee
Usa Boonyuen
Kanyanan Kritsiriwutinan
Rimi Chakrabarti
Rapatbhorn Patrapuvich
Mathirut Mungthin
Thanyapit Thita
Pradipsinh K Rathod
Kanjana Inkabjan
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Snippet The genetic diversity within the circumsporozoite surface protein (PvCSP) of 'Plasmodium vivax', the predominant malaria species in Thailand, is primarily...
The genetic diversity within the circumsporozoite surface protein (PvCSP) of , the predominant malaria species in Thailand, is primarily observed in the...
The genetic diversity within the circumsporozoite surface protein (PvCSP) of Plasmodium vivax, the predominant malaria species in Thailand, is primarily...
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SubjectTerms circumsporozoite surface protein
Evaluation
Genetic diversity
Infections
Malaria
Malaria vaccine
Plasmodium vivax
Polymerase chain reaction
Polymorphism
Proteins
Thailand
Treatment
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Title Low genetic diversity of 'Plasmodium vivax' circumsporozoite surface protein in clinical isolates from southern Thailand
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