Sex-Biased Expression and Response of microRNAs in Neurological Diseases and Neurotrauma

• Published in: International journal of molecular sciences Vol. 25; no. 5; p. 2648
• Main Authors: Geleta, Urim, Prajapati, Paresh, Bachstetter, Adam, Nelson, Peter T., Wang, Wang-Xia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.02.2024; MDPI
• Subjects: Biosynthesis; Brain research; Development and progression; Disease; Estrogens; Female; Females; Gender differences; Gene expression; Genes; Genetic research; Gonadal Steroid Hormones; Health aspects; Hormones; Hormones, Sex; Humans; Male; Males; Medical research; Medicine, Experimental; MicroRNA; MicroRNAs; MicroRNAs - genetics; Nervous System Diseases; Pathogenesis; Physiological aspects; Proteins; Review; RNA polymerase; Schizophrenia; Senescence; Traumatic brain injury; Womens health; sex biased; traumatic brain injury; neurodegenerative diseases; microRNA; miR-223-3p; X chromosome

Neurological diseases and neurotrauma manifest significant sex differences in prevalence, progression, outcome, and therapeutic responses. Genetic predisposition, sex hormones, inflammation, and environmental exposures are among many physiological and pathological factors that impact the sex dispari...