Analysis of the relationship between replication of the Hokkaido genotype of Puumala orthohantavirus and autophagy

• Published in: Virus research Vol. 318; p. 198830
• Main Authors: Tamiya, Kazuma, Kobayashi, Shintaro, Yoshii, Kentaro, Kariwa, Hiroaki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2022; Elsevier
• Subjects: autophagosomes; Autophagy; fever; genes; genotype; Hantaviruses; Japan; lysosomes; nucleocapsid proteins; Puumala orthohantavirus; Viral replication; viruses; Viral replication; Autophagy; Hantaviruses

•Autophagy is induced by the Hokkaido genotype of Puumala orthohantavirus.•Autophagy suppresses the replication of Hokkaido genotype of Puumala orthohantavirus.•Lysosomal degradation is related to the expression of the nucleocapsid protein. Hantaviruses are potentially fatal zoonotic pathogens of th...