Association of Pre- and Perinatal Risk Factors With Tourette Syndrome or Chronic Tic Disorders in a Korean School-Age Population

• Published in: Journal of the Korean Academy of Child and Adolescent Psychiatry Vol. 34; no. 1; pp. 37 - 44
• Main Authors: Choi, Wooseok, Hong, Soon-beom, Kim, Johanna Inhynag, Lee, Jung, Jang, Soomin, Ahn, Yebin D, Lim, You Bin, Kim, Sumin, Oh, Mee Rim, Kim, Bung-Nyun
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한소아청소년정신의학회 2023; Korean Academy of Child and Adolescent Psychiatry; 대한소아청소년 정신의학회
• Subjects: Age differences; Birth weight; Cesarean section; Child & adolescent psychiatry; Children & youth; Education; Etiology; Families & family life; Mental disorders; Neurodevelopmental disorders; Original; Pathogenesis; Population; Pregnancy; Questionnaires; Regression analysis; Risk factors; Schizophrenia; Tourette syndrome; Variables; 정신과학; Pregnancy; Prenatal Exposure Delayed Effects; Chronic motor or vocal tic disorder; Delivery, Obstetric; Etiology; Tourette disorder; Risk factors
• ISSN: 1225-729X; 2233-9183; 2233-9183
• DOI: 10.5765/jkacap.220024

Tic disorders are highly heritable; however, growing evidence suggests that environmental factors play a significant role in their pathogenesis. Studies on these factors have been inconsistent, with conflicting results. Therefore, this study aimed to examine the associations of pre- and perinatal exposure to Tourette syndrome (TS) or chronic tic disorders (CTD) in Korean school-aged children. This case-control study used data from a large prospective cohort study. The primary outcome was TS/CTD diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) criteria and Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version-Korean Version. Demographic, pre-, and perinatal information was obtained from the maternal questionnaires. Data between the TS/CTD and control groups were compared using the chi-squared or Student's t-test, as appropriate. Two-step logistic regression analyses were used to test the association between TS/CTD and pre- and perinatal risk factors. We included of 223 children (78 with TS/CTD and 145 controls). Significant differences in the demographic data between the two groups were observed. The male sex ratio, mean parental age, parental final education level, and family history of tics were included as confounders. In the final adjusted multivariable model, TS/CTD was significantly associated with antiemetic exposure during pregnancy (odds ratio [OR]=16.61, 95% confidence interval [CI] 1.49-185.22, p=0.02) and medically assisted reproduction (OR=7.89, 95% CI 2.28-27.28, p=0.01). Antiemetic exposure and medically assisted reproduction are significantly associated with the risk of TS/CTD. These results should be replicated in future prospective and gene-by-environment studies.