Fabrication and characterization of a thick, viable bi-layered stem cell-derived surrogate for future myocardial tissue regeneration

• Published in: Biomedical materials (Bristol) Vol. 16; no. 3; p. 35007
• Main Authors: Pretorius, Danielle, Kahn-Krell, Asher M, LaBarge, Wesley C, Lou, Xi, Kannappan, Ramaswamy, Pollard, Andrew E, Fast, Vladimir G, Berry, Joel L, Eberhardt, Alan W, Zhang, Jianyi
• Format: Journal Article
• Language: English
• Published: England 01.05.2021
• Subjects: Animals; Endothelial Cells; Humans; Induced Pluripotent Stem Cells; Mice; Myocardium; Myocytes, Cardiac; Tissue Engineering - methods; cardiac regeneration; tissue engineering; vascularization; layer-by-layer; stem cell; viscoelasticity

Cardiac tissue surrogates show promise for restoring mechanical and electrical function in infarcted left ventricular (LV) myocardium. For these cardiac surrogates to be useful , they are required to support synchronous and forceful contraction over the infarcted region. These design requirements ne...