Brown Adipose Tissue Activation in Humans Increases Plasma Levels of Lipid Mediators

• Published in: The journal of clinical endocrinology and metabolism Vol. 109; no. 7; pp. 1837 - 1849
• Main Authors: Walker, Mary E, Kodani, Sean D, Mena, Hebe Agustina, Tseng, Yu-Hua, Cypess, Aaron M, Spite, Matthew
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.07.2024
• Subjects: Acetanilides - pharmacology; Adiponectin; Adipose tissue (brown); Adipose Tissue, Brown - drug effects; Adipose Tissue, Brown - metabolism; Adipose tissues; Adrenergic beta-3 Receptor Agonists - pharmacology; Adrenergic receptors; Adult; Autocrine signalling; Body fat; Clinical; Cold; Cold Temperature; Docosahexaenoic Acids - blood; Fatty acids; Female; Healthy Volunteers; Humans; Hydroxyeicosatetraenoic Acids - blood; Hydroxyeicosatetraenoic Acids - metabolism; Lipid metabolism; Lipid Metabolism - drug effects; Lipids; Lipoxygenase; Liquid chromatography; Mass spectroscopy; Metabolic rate; Middle Aged; Mirabegron; PD-1 protein; Plasma levels; Prostaglandin E2; Prostaglandin endoperoxide synthase; Prostaglandins E; Respiratory quotient; Thermogenesis; Thermogenesis - drug effects; Thermogenesis - physiology; Thiazoles - pharmacology; Type 2 diabetes; Young Adult; brown adipose tissue; cold-exposure; lipid mediators

Abstract Context Activation of brown adipose tissue (BAT) thermogenesis improves insulin sensitivity and is beneficial in obesity. Emerging evidence indicates that BAT activation increases lipid mediators that play autocrine and endocrine roles to regulate metabolism and inflammation. Objective The...