Mechanism Repositioning Based on Integrative Pharmacology: Anti-Inflammatory Effect of Safflower in Myocardial Ischemia–Reperfusion Injury

• Published in: International journal of molecular sciences Vol. 24; no. 6; p. 5313
• Main Authors: Zhao, Feng, Jiang, Hong, Zhang, Tong, Chen, Hong, Li, Weijie, Li, Xin, Wang, Ping, Xu, Haiyu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.03.2023; MDPI
• Subjects: Analysis; Animals; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Anti-inflammatory drugs; Apoptosis; Cardiomyocytes; Carthamus tinctorius; Chemical compounds; Chromatography; Coronary vessels; Disease; Drug dosages; Drug therapy; Flavonoids; Genes; Heart; Heart attacks; Herbal medicine; Instrument industry; Interdisciplinary subjects; Ischemia; Liquid chromatography; Medical research; Medicine, Experimental; Mice; Myocardial ischemia; Myocardial Reperfusion Injury - metabolism; Pharmacology; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Superoxide; Superoxide Dismutase - pharmacology; Tandem Mass Spectrometry; Traditional Chinese medicine; United States; Massachusetts; China; LAD ligation; integrative pharmacology; myocardial ischemia–reperfusion injury; safflower; UPLC-QTOF-MS/MS; inflammation-related signaling pathways

Safflower (Carthamus tinctorius. L) possesses anti-tumor, anti-thrombotic, anti-oxidative, immunoregulatory, and cardio-cerebral protective effects. It is used clinically for the treatment of cardio-cerebrovascular disease in China. This study aimed to investigate the effects and mechanisms of actio...