Mechanism Repositioning Based on Integrative Pharmacology: Anti-Inflammatory Effect of Safflower in Myocardial Ischemia–Reperfusion Injury - Zhao, Feng; Jiang, Hong; Zhang, Tong; Chen, Hong; Li, Weijie; Li, Xin; Wang, Ping; Xu, Haiyu (International journal of molecular sciences, 2023)
Keywords: Analysis; Animals; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Anti-inflammatory drugs; Apoptosis; Cardiomyocytes; Carthamus tinctorius; Chemical compounds; Chromatography; Coronary vessels; Disease; Drug dosages; Drug therapy; Flavonoids; Genes; Heart; Heart attacks; Herbal medicine; Instrument industry; Interdisciplinary subjects; Ischemia; Liquid chromatography; Medical research; Medicine, Experimental; Mice; Myocardial ischemia; Myocardial Reperfusion Injury - metabolism; Pharmacology; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Superoxide; Superoxide Dismutase - pharmacology; Tandem Mass Spectrometry; Traditional Chinese medicine; United States; Massachusetts; China; LAD ligation; integrative pharmacology; myocardial ischemia–reperfusion injury; safflower; UPLC-QTOF-MS/MS; inflammation-related signaling pathways