Systematic comparison of exosomal proteomes from human saliva and serum for the detection of lung cancer

• Published in: Analytica chimica acta Vol. 982; pp. 84 - 95
• Main Authors: Sun, Yan, Liu, Sha, Qiao, Zhi, Shang, Zhi, Xia, Zhijun, Niu, Xiaomin, Qian, Liqiang, Zhang, Yan, Fan, Liuyin, Cao, Cheng-Xi, Xiao, Hua
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 22.08.2017; Elsevier BV
• Subjects: analytical chemistry; Biomarkers; blood serum; Body fluids; Cancer; Circulating exosomes; Diagnostic systems; Exosomes; Exosomes - chemistry; Humans; isolation techniques; Lung cancer; Lung cancer detection; lung neoplasms; Lung Neoplasms - blood; Lung Neoplasms - diagnosis; medicine; monitoring; Patients; protein composition; Proteins; proteome; Proteome - chemistry; Proteomics; Quantitative proteomics; Saliva; Saliva - chemistry; Serum; Target detection; Lung cancer detection; Serum; Quantitative proteomics; Circulating exosomes; Saliva

Circulating tumor exosomes harbor plenty of cancer biological information, which have emerged as promising targets for cancer early detection and diagnosis. Human serum and saliva are unique diagnostic body fluids, which contain numerous circulating exosomes. It is necessary to establish standardize...