Systematic comparison of exosomal proteomes from human saliva and serum for the detection of lung cancer

Circulating tumor exosomes harbor plenty of cancer biological information, which have emerged as promising targets for cancer early detection and diagnosis. Human serum and saliva are unique diagnostic body fluids, which contain numerous circulating exosomes. It is necessary to establish standardize...

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Published in	Analytica chimica acta Vol. 982; pp. 84 - 95
Main Authors	Sun, Yan, Liu, Sha, Qiao, Zhi, Shang, Zhi, Xia, Zhijun, Niu, Xiaomin, Qian, Liqiang, Zhang, Yan, Fan, Liuyin, Cao, Cheng-Xi, Xiao, Hua
Format	Journal Article
Language	English
Published	Netherlands Elsevier B.V 22.08.2017 Elsevier BV
Subjects	analytical chemistry Biomarkers blood serum Body fluids Cancer Circulating exosomes Diagnostic systems Exosomes Exosomes - chemistry Humans isolation techniques Lung cancer Lung cancer detection lung neoplasms Lung Neoplasms - blood Lung Neoplasms - diagnosis medicine monitoring Patients protein composition Proteins proteome Proteome - chemistry Proteomics Quantitative proteomics Saliva Saliva - chemistry Serum Target detection Lung cancer detection Serum Quantitative proteomics Circulating exosomes Saliva
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Abstract	Circulating tumor exosomes harbor plenty of cancer biological information, which have emerged as promising targets for cancer early detection and diagnosis. Human serum and saliva are unique diagnostic body fluids, which contain numerous circulating exosomes. It is necessary to establish standardized isolation method and compare their proteome profiling for translational medicine. High abundant proteins in these body fluids were removed before exosomes isolation and obtained exosomes were further confirmed by morphology analysis and surface biomarker test. Label free quantification was applied to systematically compare the protein profiling in saliva and serum exosomes. 319 and 994 exosomal proteins were identified from saliva and serum by LC-MS/MS, respectively. To explore their utility for cancer proteomics, we systematically compared the proteome of saliva and serum exosomes from healthy subjects and lung cancer patients. In particular, 11 potential candidates were coincidently discovered in both body fluids of lung cancer patients. Our finding enforced the hypothesis that cancer related proteins were presented in saliva and serum exosomes, which promoted the unique features of exosomes in our body fluids. A circulating exosomes based body fluid test could be easily established for monitoring cancer once these candidates were validated. [Display omitted] •319 and 994 exosomal proteins were identified from human saliva and serum, respectively.•Around 80% of salivary exosomal proteins were shared with serum exosomes.•11 exosomal proteins were coincidently discovered in saliva and serum for the detection of lung cancer.
AbstractList	Circulating tumor exosomes harbor plenty of cancer biological information, which have emerged as promising targets for cancer early detection and diagnosis. Human serum and saliva are unique diagnostic body fluids, which contain numerous circulating exosomes. It is necessary to establish standardized isolation method and compare their proteome profiling for translational medicine. High abundant proteins in these body fluids were removed before exosomes isolation and obtained exosomes were further confirmed by morphology analysis and surface biomarker test. Label free quantification was applied to systematically compare the protein profiling in saliva and serum exosomes. 319 and 994 exosomal proteins were identified from saliva and serum by LC-MS/MS, respectively. To explore their utility for cancer proteomics, we systematically compared the proteome of saliva and serum exosomes from healthy subjects and lung cancer patients. In particular, 11 potential candidates were coincidently discovered in both body fluids of lung cancer patients. Our finding enforced the hypothesis that cancer related proteins were presented in saliva and serum exosomes, which promoted the unique features of exosomes in our body fluids. A circulating exosomes based body fluid test could be easily established for monitoring cancer once these candidates were validated. [Display omitted] •319 and 994 exosomal proteins were identified from human saliva and serum, respectively.•Around 80% of salivary exosomal proteins were shared with serum exosomes.•11 exosomal proteins were coincidently discovered in saliva and serum for the detection of lung cancer. Circulating tumor exosomes harbor plenty of cancer biological information, which have emerged as promising targets for cancer early detection and diagnosis. Human serum and saliva are unique diagnostic body fluids, which contain numerous circulating exosomes. It is necessary to establish standardized isolation method and compare their proteome profiling for translational medicine. High abundant proteins in these body fluids were removed before exosomes isolation and obtained exosomes were further confirmed by morphology analysis and surface biomarker test. Label free quantification was applied to systematically compare the protein profiling in saliva and serum exosomes. 319 and 994 exosomal proteins were identified from saliva and serum by LC-MS/MS, respectively. To explore their utility for cancer proteomics, we systematically compared the proteome of saliva and serum exosomes from healthy subjects and lung cancer patients. In particular, 11 potential candidates were coincidently discovered in both body fluids of lung cancer patients. Our finding enforced the hypothesis that cancer related proteins were presented in saliva and serum exosomes, which promoted the unique features of exosomes in our body fluids. A circulating exosomes based body fluid test could be easily established for monitoring cancer once these candidates were validated. Circulating tumor exosomes harbor plenty of cancer biological information, which have emerged as promising targets for cancer early detection and diagnosis. Human serum and saliva are unique diagnostic body fluids, which contain numerous circulating exosomes. It is necessary to establish standardized isolation method and compare their proteome profiling for translational medicine. High abundant proteins in these body fluids were removed before exosomes isolation and obtained exosomes were further confirmed by morphology analysis and surface biomarker test. Label free quantification was applied to systematically compare the protein profiling in saliva and serum exosomes. 319 and 994 exosomal proteins were identified from saliva and serum by LC-MS/MS, respectively. To explore their utility for cancer proteomics, we systematically compared the proteome of saliva and serum exosomes from healthy subjects and lung cancer patients. In particular, 11 potential candidates were coincidently discovered in both body fluids of lung cancer patients. Our finding enforced the hypothesis that cancer related proteins were presented in saliva and serum exosomes, which promoted the unique features of exosomes in our body fluids. A circulating exosomes based body fluid test could be easily established for monitoring cancer once these candidates were validated.Circulating tumor exosomes harbor plenty of cancer biological information, which have emerged as promising targets for cancer early detection and diagnosis. Human serum and saliva are unique diagnostic body fluids, which contain numerous circulating exosomes. It is necessary to establish standardized isolation method and compare their proteome profiling for translational medicine. High abundant proteins in these body fluids were removed before exosomes isolation and obtained exosomes were further confirmed by morphology analysis and surface biomarker test. Label free quantification was applied to systematically compare the protein profiling in saliva and serum exosomes. 319 and 994 exosomal proteins were identified from saliva and serum by LC-MS/MS, respectively. To explore their utility for cancer proteomics, we systematically compared the proteome of saliva and serum exosomes from healthy subjects and lung cancer patients. In particular, 11 potential candidates were coincidently discovered in both body fluids of lung cancer patients. Our finding enforced the hypothesis that cancer related proteins were presented in saliva and serum exosomes, which promoted the unique features of exosomes in our body fluids. A circulating exosomes based body fluid test could be easily established for monitoring cancer once these candidates were validated.
Author	Xiao, Hua Fan, Liuyin Qiao, Zhi Cao, Cheng-Xi Niu, Xiaomin Shang, Zhi Xia, Zhijun Liu, Sha Zhang, Yan Qian, Liqiang Sun, Yan
Author_xml	– sequence: 1 givenname: Yan surname: Sun fullname: Sun, Yan organization: State Key Laboratory of Microbial Metabolism, Laboratory of Analytical Biochemistry and Bioseparation, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China – sequence: 2 givenname: Sha surname: Liu fullname: Liu, Sha organization: State Key Laboratory of Microbial Metabolism, Laboratory of Analytical Biochemistry and Bioseparation, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China – sequence: 3 givenname: Zhi surname: Qiao fullname: Qiao, Zhi organization: State Key Laboratory of Microbial Metabolism, Laboratory of Analytical Biochemistry and Bioseparation, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China – sequence: 4 givenname: Zhi surname: Shang fullname: Shang, Zhi organization: State Key Laboratory of Microbial Metabolism, Laboratory of Analytical Biochemistry and Bioseparation, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China – sequence: 5 givenname: Zhijun surname: Xia fullname: Xia, Zhijun organization: State Key Laboratory of Microbial Metabolism, Laboratory of Analytical Biochemistry and Bioseparation, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China – sequence: 6 givenname: Xiaomin surname: Niu fullname: Niu, Xiaomin organization: Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China – sequence: 7 givenname: Liqiang surname: Qian fullname: Qian, Liqiang organization: Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China – sequence: 8 givenname: Yan surname: Zhang fullname: Zhang, Yan organization: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China – sequence: 9 givenname: Liuyin surname: Fan fullname: Fan, Liuyin organization: State Key Laboratory of Microbial Metabolism, Laboratory of Analytical Biochemistry and Bioseparation, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China – sequence: 10 givenname: Cheng-Xi surname: Cao fullname: Cao, Cheng-Xi email: cxcao@sjtu.edu.cn organization: State Key Laboratory of Microbial Metabolism, Laboratory of Analytical Biochemistry and Bioseparation, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China – sequence: 11 givenname: Hua orcidid: 0000-0002-2831-0436 surname: Xiao fullname: Xiao, Hua email: huaxiao@sjtu.edu.cn organization: State Key Laboratory of Microbial Metabolism, Laboratory of Analytical Biochemistry and Bioseparation, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China
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Copyright	2017 Elsevier B.V. Copyright © 2017 Elsevier B.V. All rights reserved. Copyright Elsevier BV Aug 22, 2017
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Keywords	Lung cancer detection Serum Quantitative proteomics Circulating exosomes Saliva
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Snippet	Circulating tumor exosomes harbor plenty of cancer biological information, which have emerged as promising targets for cancer early detection and diagnosis....
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SubjectTerms	analytical chemistry Biomarkers blood serum Body fluids Cancer Circulating exosomes Diagnostic systems Exosomes Exosomes - chemistry Humans isolation techniques Lung cancer Lung cancer detection lung neoplasms Lung Neoplasms - blood Lung Neoplasms - diagnosis medicine monitoring Patients protein composition Proteins proteome Proteome - chemistry Proteomics Quantitative proteomics Saliva Saliva - chemistry Serum Target detection
Title	Systematic comparison of exosomal proteomes from human saliva and serum for the detection of lung cancer
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