Development of treatment concepts for the use of botulinum toxin a in children with cerebral palsy

• Published in: Toxins Vol. 2; no. 9; pp. 2258 - 2271
• Main Authors: Placzek, Richard, Siebold, Dagmar, Funk, Julia F
• Format: Journal Article Book Review
• Language: English
• Published: Switzerland MDPI AG 01.09.2010; MDPI
• Subjects: botulinum toxin A; Botulinum Toxins, Type A - adverse effects; Botulinum Toxins, Type A - therapeutic use; cerebral palsy; Cerebral Palsy - complications; Cerebral Palsy - drug therapy; Cerebral Palsy - physiopathology; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Injections, Intramuscular; key-muscle concept; Motor Activity - drug effects; Motor Activity - physiology; multi-level treatment; Muscle Spasticity - drug therapy; Muscle Spasticity - etiology; Muscle Spasticity - physiopathology; Muscle, Skeletal - drug effects; Muscle, Skeletal - physiopathology; Neuromuscular Agents - adverse effects; Neuromuscular Agents - therapeutic use; Review; cerebral palsy; multi-level treatment; botulinum toxin A; CP; key-muscle concept

The treatment of children with cerebral palsy with Botulinum toxin A injections is well established, safe and effective. However, a standardized injection strategy is still missing and the used dosage has escalated over the years. In the recent past, the recommended dosages in Europe were, however,...