Organocatalyzed Enantioselective [3+2] Cycloaddition Reactions for Synthesis of Dispiro[benzothiophenone-indandione-pyrrolidine] Derivatives

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 20; p. 4856
• Main Authors: Liu, Hong-Yan, Du, Da-Ming
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.10.2024; MDPI
• Subjects: 2-arylidene-1,3-indandione; asymmetric catalysis; benzothiophenone; Cancer; Chlorine; Clinical medicine; Diffraction; Fluorine; Medical research; Performance evaluation; Solvents; spirocyclic compounds; squaramide; thiourea; X-rays; thiourea; asymmetric catalysis; squaramide; 2-arylidene-1,3-indandione; spirocyclic compounds; benzothiophenone

An organocatalytic enantioselective [3+2] cycloaddition reaction involving 2-arylidene-1,3-indandiones and N-2,2-difluoroethylbenzothiophenone imines was developed. This approach efficiently afforded dispiro[benzothiophenone-indandione-pyrrolidine]s, featuring three stereocenters, in 84–98% yields w...