Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women

• Published in: Experimental gerontology Vol. 65; pp. 1 - 7
• Main Authors: Markofski, Melissa M., Dickinson, Jared M., Drummond, Micah J., Fry, Christopher S., Fujita, Satoshi, Gundermann, David M., Glynn, Erin L., Jennings, Kristofer, Paddon-Jones, Douglas, Reidy, Paul T., Sheffield-Moore, Melinda, Timmerman, Kyle L., Rasmussen, Blake B., Volpi, Elena
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.05.2015
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Aging - physiology; Female; Gender; Humans; Male; Mechanistic Target of Rapamycin Complex 1; Middle Aged; mTOR; Multiprotein Complexes - metabolism; Muscle Contraction - physiology; Muscle Proteins - biosynthesis; Muscle Proteins - metabolism; Muscle, Skeletal - physiology; Phosphorylation - physiology; Protein metabolism; Ribosomal Protein S6 Kinases, 70-kDa - metabolism; Sarcopenia; Sex Factors; Signal Transduction - physiology; Stable isotopes; TOR Serine-Threonine Kinases - metabolism; Aging; mTOR; Sarcopenia; Protein metabolism; Gender; Stable isotopes

The rate of muscle loss with aging is higher in men than women. However, women have smaller muscles throughout the adult life. Protein content is a major determinant of skeletal muscle size. This study was designed to determine if age and sex differentially impact basal muscle protein synthesis and...