Protective effects of resveratrol on aging-induced cognitive impairment in rats

• Published in: Neurobiology of learning and memory Vol. 131; pp. 131 - 136
• Main Authors: Gocmez, Semil Selcen, Gacar, Nejat, Utkan, Tijen, Gacar, Gulcin, Scarpace, Philip J., Tumer, Nihal
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2016; Elsevier BV
• Subjects: Aging; Aging - drug effects; Aging - physiology; Animal cognition; Animals; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Avoidance Learning - drug effects; Avoidance Learning - physiology; Behavior, Animal - drug effects; Behavior, Animal - physiology; Cognitive Dysfunction - drug therapy; Cognitive Dysfunction - physiopathology; Cytokines - drug effects; Cytokines - metabolism; Disease Models, Animal; Inflammation - drug therapy; Inflammation - metabolism; Inflammatory cytokines; Learning and memory; Male; Neurobiology; Neurodegeneration; Polyphenols; Rats, Wistar; Resveratrol; Rodents; Spatial Learning - drug effects; Spatial Learning - physiology; Stilbenes - administration & dosage; Stilbenes - pharmacology; Learning and memory; Aging; Inflammatory cytokines; Resveratrol

•Aging impaired emotional and spatial learning and memory in rats.•Inflammatory cytokines were increased by aging.•Resveratrol reversed the aging impaired cognitive functions.•Resveratrol prevented elevations of inflammatory cytokines in aged rats.•Antiinflammatory effects of resveratrol can be prot...