Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B
Botulinum neurotoxin type B (BoNT/B) recognizes nerve terminals by binding to 2 receptor components: a polysialoganglioside, predominantly GT1b, and synaptotagmin 1/2. It is widely thought that BoNT/B initially binds to GT1b then diffuses in the plane of the membrane to interact with synaptotagmin....
Saved in:
Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 36; pp. 18098 - 18108 |
---|---|
Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
National Academy of Sciences
03.09.2019
|
Series | PNAS Plus |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Be the first to leave a comment!