Familial Dilated Cardiomyopathy: A Novel MED9 Short Isoform Identification

• Published in: International journal of molecular sciences Vol. 25; no. 5; p. 3057
• Main Authors: Franzese, Monica, Zanfardino, Mario, Soricelli, Andrea, Coppola, Annapaola, Maiello, Ciro, Salvatore, Marco, Schiano, Concetta, Napoli, Claudio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2024; MDPI
• Subjects: Brief Report; Cardiac arrhythmia; Cardiomyopathy; Cardiomyopathy, Dilated; Cardiomyopathy, Dilated - genetics; Coronary heart disease; Development and progression; Ejection fraction; Gene expression; Genes; Genetic aspects; Genomes; Heart; Heart Transplantation; Humans; Mitochondrial DNA; Mutation; Pacemakers; Patients; Protein Isoforms; Proteins; RNA; RNA polymerase; RNA sequencing; Transplantation; RNA sequencing; atherosclerosis; mediator complex; heart failure; precision medicine; dilated cardiomyopathy

Familial dilated cardiomyopathy (DCM) is among the leading indications for heart transplantation. DCM alters the transcriptomic profile. The alteration or activation/silencing of physiologically operating transcripts may explain the onset and progression of this pathological state. The mediator comp...