Low-dose Rasburicase in Hematologic Malignancies

• Published in: Indian journal of pediatrics Vol. 82; no. 5; pp. 458 - 461
• Main Authors: Jayabose, Somasundaram, Kumar, Vignesh, Dhanabalan, Rajeswari, Rajan, Priya, Rathnam, Krishnakumar, Viswanathan, T. Kasi
• Format: Journal Article
• Language: English
• Published: India Springer India 01.05.2015
• Subjects: Adolescent; Child; Child, Preschool; Female; Gout Suppressants - administration & dosage; Gout Suppressants - adverse effects; Gynecology; Hematologic Neoplasms - drug therapy; Humans; India; Infant; Male; Medicine; Medicine & Public Health; Original Article; Pediatrics; Retrospective Studies; Tumor Lysis Syndrome - drug therapy; Urate Oxidase - administration & dosage; Urate Oxidase - adverse effects; Uric Acid - blood; Young Adult; Hyperphosphatemia; Hyperuricemia; Rasburicase; Tumor lysis syndrome; Lymphoma; Leukemia

Objective To define the efficacy and safety of low-dose rasburicase in children from south India with hematologic malignancies. Methods This study is a retrospective analysis of data on 41 children with hematologic malignacies with laboratory evidence of tumor lysis syndrome (TLS) or clinical featur...