Menstrual blood-derived mesenchymal stem cells differentiate into functional hepatocyte-like cells

• Published in: Journal of Zhejiang University. B. Science Vol. 14; no. 11; pp. 961 - 972
• Main Authors: Mou, Xiao-zhou, Lin, Jian, Chen, Jin-yang, Li, Yi-fei, Wu, Xiao-xing, Xiang, Bing-yu, Li, Cai-yun, Ma, Ju-ming, Xiang, Charlie
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2013; Springer Nature B.V; Zhejiang University Press
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Cell Differentiation; Cell Separation; End Stage Liver Disease - therapy; Hepatocytes - cytology; Hepatocytes - transplantation; Humans; Male; Menstruation - blood; Mesenchymal Stromal Cells - cytology; Mice; Mice, Inbred BALB C; Hepatocyte; Menstrual blood-derived mesenchymal stem cell (MenSC); Intrasplenic transplantation; Differentiation; Partial hepatectomy; Q813; R51

Orthotopic liver transplantation （OLT） is the only proven effective treatment for both end-stage and me- tabolic liver diseases. Hepatocyte transplantation is a promising alternative for OLT, but the lack of available donor livers has hampered its clinical application. Hepatocyte-like cells （HLCs） d...