Safety evaluation of fospropofol for sedation during minor surgical procedures

• Published in: Journal of clinical anesthesia Vol. 22; no. 4; pp. 260 - 267
• Main Authors: Gan, Tong J., MD, Berry, Bradley D., MD, Ekman, Evan F., MD, Muckerman, Richard C., MD, Shore, Neal, MD, Hardi, Robert, MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.06.2010; Elsevier; Elsevier Limited
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Airway management; Analgesics; Anesthesia; Anesthesia & Perioperative Care; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthetics, Intravenous - therapeutic use; Aqueous solutions; Biological and medical sciences; Drug Administration Schedule; Drug dosages; Drug therapy; Female; Fentanyl - therapeutic use; Fospropofol; Humans; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - adverse effects; Hypnotics and Sedatives - therapeutic use; Male; Medical sciences; Medical screening; Middle Aged; Minor surgery; Minor Surgical Procedures - methods; Moderate sedation; Pain; Pain Medicine; Patient safety; Propofol - administration & dosage; Propofol - adverse effects; Propofol - analogs & derivatives; Propofol - therapeutic use; Review boards; Young Adult; Fospropofol; Patient safety; Moderate sedation; Minor surgery; Human; General anesthetic; Surgery; Anesthesia; Prodrug; Sedation

Abstract Study Objective To evaluate the safety of intravenous (IV) fospropofol when used to provide minimal to moderate sedation in patients undergoing minor surgical procedures. Design Phase 3, open-label, single-arm study. Setting Multi-center. Patients 123 ASA physical status I, II, III, and IV...