Adaptive and Innate Cytotoxic Effectors in Chronic Lymphocytic Leukaemia (CLL) Subjects with Stable Disease

• Published in: International journal of molecular sciences Vol. 24; no. 11; p. 9596
• Main Authors: Rubino, Valentina, Carriero, Flavia, Palatucci, Anna Teresa, Giovazzino, Angela, Leone, Stefania, Nicolella, Valerio, Calabrò, Martina, Montanaro, Rosangela, Brancaleone, Vincenzo, Pane, Fabrizio, Chiurazzi, Federico, Ruggiero, Giuseppina, Terrazzano, Giuseppe
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.05.2023; MDPI
• Subjects: Antigens; Antineoplastic Agents; B-Lymphocytes; Biological response modifiers; Cells; Cloning; Cytotoxicity; Ferrone, Soldano; Histocompatibility antigens; Histocompatibility Antigens Class I; HLA histocompatibility antigens; Humans; Interferon; Killer Cells, Natural; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; T-Lymphocytes, Cytotoxic; Tumor Microenvironment; immune activation profile; NK cells; chronic lymphocytic leukaemia; cytotoxic T cells; HLA class I molecules
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms24119596

Chronic lymphocytic leukaemia (CLL) is characterised by the expansion of a neoplastic mature B cell clone. CLL clinical outcome is very heterogeneous, with some subjects never requiring therapy and some showing an aggressive disease. Genetic and epigenetic alterations and pro-inflammatory microenvir...