Multiple Roles of the Stress Sensor GCN2 in Immune Cells

• Published in: International journal of molecular sciences Vol. 24; no. 5; p. 4285
• Main Authors: Zhao, Chenxu, Guo, Han, Hou, Yangxiao, Lei, Tong, Wei, Dong, Zhao, Yong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.02.2023; MDPI
• Subjects: Amino acids; Amino Acids - metabolism; Cell cycle; Endoplasmic reticulum; Genetic translation; Heat shock proteins; Homeostasis; Humans; Kinases; Oxidative stress; Phosphatase; Phosphorylation; Physiological aspects; Protein kinases; Protein Serine-Threonine Kinases - metabolism; Protein synthesis; Review; Roles; Signal Transduction; Stress, Physiological; T cells; T-Lymphocyte Subsets - metabolism; Transfer RNA; Yeast; immune system; GCN2; stress; tumor; protein kinase

The serine/threonine-protein kinase general control nonderepressible 2 (GCN2) is a well-known stress sensor that responds to amino acid starvation and other stresses, making it critical to the maintenance of cellular and organismal homeostasis. More than 20 years of research has revealed the molecul...