The Diverse Nature of the Molecular Interactions That Govern the COV-2 Variants’ Cell Receptor Affinity Ranking and Its Experimental Variability

• Published in: International journal of molecular sciences Vol. 25; no. 5; p. 2585
• Main Authors: Sussman, Fredy, Villaverde, Daniel S.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.02.2024; MDPI
• Subjects: Antibodies; Cell Membrane; COVID-19; Experiments; Glycoproteins; Humans; Mutation; Proteins; Rankings; Receptors, Cell Surface; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Vaccines; Virulence; molecular mechanism; COV-2; molecular mechanics calculations; spike–receptor affinities; variants of concern; variant infectivity

A critical determinant of infectivity and virulence of the most infectious and or lethal variants of concern (VOCs): Wild Type, Delta and Omicron is related to the binding interactions between the receptor-binding domain of the spike and its host receptor, the initial step in cell infection. It is o...