Plasma metabolomic profiling as a tool to identify predictive biomarkers of methotrexate efficacy in rheumatoid arthritis

• Published in: Seminars in arthritis and rheumatism Vol. 56; p. 152056
• Main Authors: Medcalf, Matthew R., Bantis, Leonidas E., Shi, Peng, Bhadbhade, Pooja, Gundry, Rebekah L., Mikuls, Ted R., England, Bryant R., O'Dell, James R., Funk, Ryan S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2022
• Subjects: Antirheumatic Agents - therapeutic use; Arthritis, Rheumatoid - drug therapy; Biomarker; Biomarkers; Drug Therapy, Combination; Humans; Metabolome; Metabolomics; Methotrexate; Methotrexate - therapeutic use; Plasma; Rheumatoid arthritis; Treatment Outcome; Metabolome; Metabolomics; Plasma; Biomarker; Methotrexate; Rheumatoid arthritis

Methotrexate (MTX) remains the first-choice disease-modifying therapy in rheumatoid arthritis (RA). However, clinical response is variable, and no reliable predictive biomarkers of efficacy currently exist. In this study, plasma metabolomic profiling is evaluated as a tool to identify pretreatment b...