Relation of central adiposity and body mass index to the development of diabetes in the Diabetes Prevention Program

• Published in: The American journal of clinical nutrition Vol. 87; no. 5; pp. 1212 - 1218
• Main Authors: Bray, George A, Jablonski, Kathleen A, Fujimoto, Wilfred Y, Barrett-Connor, Elizabeth, Haffner, Steven, Hanson, Robert L, Hill, James O, Hubbard, Van, Kriska, Andrea, Stamm, Elizabeth, Pi-Sunyer, F. Xavier
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Nutrition 01.05.2008; American Society for Clinical Nutrition; American Society for Clinical Nutrition, Inc
• Subjects: abdominal fat; adipose tissue; Adult; adults; Biological and medical sciences; Body Composition - physiology; Body fat; Body Height - physiology; Body Mass Index; Diabetes; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - prevention & control; Diabetes Prevention Program; Disease prevention; drug therapy; Ethnicity; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Humans; Hypoglycemic Agents - therapeutic use; Intra-Abdominal Fat - anatomy & histology; Intra-Abdominal Fat - diagnostic imaging; Life Style; lifestyle; Lumbar Vertebrae; Male; Measurement; metformin; Metformin - therapeutic use; Middle Aged; Obesity - complications; Obesity - therapy; prediction; Predictive Value of Tests; Primary Prevention; Proportional Hazards Models; Risk; Risk Factors; Sex Factors; subcutaneous fat; Subcutaneous Fat - anatomy & histology; Subcutaneous Fat - diagnostic imaging; Time Factors; Tomography, X-Ray Computed - methods; Vertebrates: anatomy and physiology, studies on body, several organs or systems; visceral fat; waist circumference; Waist-Hip Ratio; waist-to-hip ratio; Endocrinopathy; Human; Prevention; Body mass index; Adiposity; Diabetes mellitus; Development

BACKGROUND: Greater central adiposity is related to the risk of diabetes. OBJECTIVE: We aimed to test the hypothesis that central adiposity measured by computed tomography (CT) is a better predictor of the risk of diabetes than is body mass index (BMI), waist circumference (WC), waist/hip ratio (WHR...