Assessing the occurrence of a stress syndrome in mussels ( Mytilus edulis) using a combined biomarker/gene expression approach

• Published in: Aquatic toxicology Vol. 78; no. 1; pp. S13 - S24
• Main Authors: Dondero, Francesco, Dagnino, Alessandro, Jonsson, Henrik, Caprì, Flavia, Gastaldi, Laura, Viarengo, Aldo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2006
• Subjects: abiotic stress; algorithms; Animals; Biomarkers; Biomarkers - analysis; Calcium-Transporting ATPases - drug effects; Calcium-Transporting ATPases - metabolism; Catalase - drug effects; Catalase - metabolism; Copper; Copper - toxicity; DNA Primers - chemistry; Environmental Exposure; enzyme activity; gene activation; gene expression; Gene Expression Profiling - veterinary; Glutathione Transferase - drug effects; Heavy metals; Lipids - analysis; Lipofuscin - analysis; Lysosomes - drug effects; Lysosomes - enzymology; Lysosomes - metabolism; Metallothionein - analysis; Metallothionein - genetics; Metallothionein - physiology; Microarray; microarray technology; Mussel; mussels; Mytilus edulis; Mytilus edulis - drug effects; Mytilus edulis - enzymology; Mytilus edulis - physiology; Norway; Oligonucleotide Array Sequence Analysis - methods; polymerase chain reaction; Reverse Transcriptase Polymerase Chain Reaction - veterinary; Risk assessment; Up-Regulation; Water Pollutants, Chemical - toxicity; water pollution; Norway; Biomarkers; Mussel; Copper; Microarray; Risk assessment; Heavy metals

A combination of biomarkers and gene expression analyses was used to investigate the occurrence of a stress syndrome in mussels ( Mytilus edulis) caged along a copper pollution gradient in the Visnes fjord, Norway. The stress level in mussels, as calculated by a novel algorithm (the “Expert System”)...