Melatonin and Kidney Health: From Fetal Stage to Later Life

Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance gl...

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Published inInternational journal of molecular sciences Vol. 24; no. 9; p. 8105
Main Authors Tang, Kuo-Shu, Ho, Chun-Yi, Hsu, Chien-Ning, Tain, You-Lin
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 30.04.2023
MDPI
Subjects
Analysis
Animals
Breastfeeding & lactation
Chronic kidney failure
Circadian Rhythm
Endocrine system
Fetuses
Hypertension
Kidney
Kidney diseases
Melatonin
Melatonin - pharmacology
Melatonin - therapeutic use
Metabolism
Metabolites
Models, Animal
Physiology
Pineal Gland
Placenta
Pregnancy
Premature birth
Renal Insufficiency, Chronic - drug therapy
Review
Skin
Urine
Womens health
Taiwan
antioxidant
circadian rhythm
pregnancy
developmental origin of health and disease (DOHaD)
kidney disease
melatonin
developmental programming
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Abstract Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin’s effect on kidney development, its clinical uses in the early stage of life, animal models documenting preventive applications of melatonin on offspring’s kidney-related disease, and a thorough summary of therapeutic considerations concerning melatonin supplementation.
AbstractList Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin’s effect on kidney development, its clinical uses in the early stage of life, animal models documenting preventive applications of melatonin on offspring’s kidney-related disease, and a thorough summary of therapeutic considerations concerning melatonin supplementation.
Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin's effect on kidney development, its clinical uses in the early stage of life, animal models documenting preventive applications of melatonin on offspring's kidney-related disease, and a thorough summary of therapeutic considerations concerning melatonin supplementation.Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin's effect on kidney development, its clinical uses in the early stage of life, animal models documenting preventive applications of melatonin on offspring's kidney-related disease, and a thorough summary of therapeutic considerations concerning melatonin supplementation.
Audience Academic
Author Hsu, Chien-Ning
Tain, You-Lin
Tang, Kuo-Shu
Ho, Chun-Yi
AuthorAffiliation 3 Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
6 College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
2 Department of Pediatrics, Kaohsiung Municipal Feng Shan Hospital—Under the Management of Chang Gung Medical Foundation, Kaohsiung 830, Taiwan
4 School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
1 Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
5 Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
AuthorAffiliation_xml – name: 2 Department of Pediatrics, Kaohsiung Municipal Feng Shan Hospital—Under the Management of Chang Gung Medical Foundation, Kaohsiung 830, Taiwan
– name: 1 Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
– name: 4 School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
– name: 6 College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
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  fullname: Tain, You-Lin
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Issue 9
Keywords antioxidant
circadian rhythm
pregnancy
developmental origin of health and disease (DOHaD)
kidney disease
melatonin
developmental programming
Language English
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Snippet Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a...
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SubjectTerms Analysis
Animals
Breastfeeding & lactation
Chronic kidney failure
Circadian Rhythm
Endocrine system
Fetuses
Hypertension
Kidney
Kidney diseases
Melatonin
Melatonin - pharmacology
Melatonin - therapeutic use
Metabolism
Metabolites
Models, Animal
Physiology
Pineal Gland
Placenta
Pregnancy
Premature birth
Renal Insufficiency, Chronic - drug therapy
Review
Skin
Urine
Womens health
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Title Melatonin and Kidney Health: From Fetal Stage to Later Life
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Volume 24
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