Circulating filarial antigen detection in brugian filariasis
Human lymphatic filariasis (LF) is a major cause of disability globally. The success of global elimination programmes for LF depends upon effectiveness of tools for diagnosis and treatment. In this study on stage-specific antigen detection in brugian filariasis, L3, adult worm (AW) and microfilarial...
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| Published in | Parasitology Vol. 143; no. 3; pp. 350 - 357 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Cambridge, UK
Cambridge University Press
01.03.2016
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| Abstract | Human lymphatic filariasis (LF) is a major cause of disability globally. The success of global elimination programmes for LF depends upon effectiveness of tools for diagnosis and treatment. In this study on stage-specific antigen detection in brugian filariasis, L3, adult worm (AW) and microfilarial antigenaemia were detected in around 90–95% of microfilariae carriers (MF group), 50–70% of adenolymphangitis (ADL) patients, 10–25% of chronic pathology (CP) patients and 10–15% of endemic normal (EN) controls. The sensitivity of the circulating filarial antigen (CFA) detection in serum samples from MF group was up to 95%. In sera from ADL patients, unexpectedly, less antigen reactivity was observed. In CP group all the CFA positive individuals were from CP grade I and II only and none from grade III or IV, suggesting that with chronicity the AWs lose fecundity and start to disintegrate and die. Amongst EN subject, 10–15% had CFA indicating that few of them harbour filarial AWs, thus they might not be truly immune as has been conventionally believed. The specificity for antigen detection was 100% when tested with sera from various other protozoan and non-filarial helminthic infections. |
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| AbstractList | Human lymphatic filariasis (LF) is a major cause of disability globally. The success of global elimination programmes for LF depends upon effectiveness of tools for diagnosis and treatment. In this study on stage-specific antigen detection in brugian filariasis, L3, adult worm (AW) and microfilarial antigenaemia were detected in around 90–95% of microfilariae carriers (MF group), 50–70% of adenolymphangitis (ADL) patients, 10–25% of chronic pathology (CP) patients and 10–15% of endemic normal (EN) controls. The sensitivity of the circulating filarial antigen (CFA) detection in serum samples from MF group was up to 95%. In sera from ADL patients, unexpectedly, less antigen reactivity was observed. In CP group all the CFA positive individuals were from CP grade I and II only and none from grade III or IV, suggesting that with chronicity the AWs lose fecundity and start to disintegrate and die. Amongst EN subject, 10–15% had CFA indicating that few of them harbour filarial AWs, thus they might not be truly immune as has been conventionally believed. The specificity for antigen detection was 100% when tested with sera from various other protozoan and non-filarial helminthic infections. SUMMARYHuman lymphatic filariasis (LF) is a major cause of disability globally. The success of global elimination programmes for LF depends upon effectiveness of tools for diagnosis and treatment. In this study on stage-specific antigen detection in brugian filariasis, L3, adult worm (AW) and microfilarial antigenaemia were detected in around 90–95% of microfilariae carriers (MF group), 50–70% of adenolymphangitis (ADL) patients, 10–25% of chronic pathology (CP) patients and 10–15% of endemic normal (EN) controls. The sensitivity of the circulating filarial antigen (CFA) detection in serum samples from MF group was up to 95%. In sera from ADL patients, unexpectedly, less antigen reactivity was observed. In CP group all the CFA positive individuals were from CP grade I and II only and none from grade III or IV, suggesting that with chronicity the AWs lose fecundity and start to disintegrate and die. Amongst EN subject, 10–15% had CFA indicating that few of them harbour filarial AWs, thus they might not be truly immune as has been conventionally believed. The specificity for antigen detection was 100% when tested with sera from various other protozoan and non-filarial helminthic infections. SUMMARY Human lymphatic filariasis (LF) is a major cause of disability globally. The success of global elimination programmes for LF depends upon effectiveness of tools for diagnosis and treatment. In this study on stage-specific antigen detection in brugian filariasis, L3, adult worm (AW) and microfilarial antigenaemia were detected in around 90-95% of microfilariae carriers (MF group), 50-70% of adenolymphangitis (ADL) patients, 10-25% of chronic pathology (CP) patients and 10-15% of endemic normal (EN) controls. The sensitivity of the circulating filarial antigen (CFA) detection in serum samples from MF group was up to 95%. In sera from ADL patients, unexpectedly, less antigen reactivity was observed. In CP group all the CFA positive individuals were from CP grade I and II only and none from grade III or IV, suggesting that with chronicity the AWs lose fecundity and start to disintegrate and die. Amongst EN subject, 10-15% had CFA indicating that few of them harbour filarial AWs, thus they might not be truly immune as has been conventionally believed. The specificity for antigen detection was 100% when tested with sera from various other protozoan and non-filarial helminthic infections. |
| Author | TRIPATHI, PRAVEEN KUMAR SHENOY, RANGANATHA KRISHNA MALLA, NANCY BHATTACHARYA, SHAILJA MISRA MAHAJAN, RAMESH CHANDER SEHGAL, RAKESH MEWARA, ABHISHEK |
| Author_xml | – sequence: 1 givenname: PRAVEEN KUMAR surname: TRIPATHI fullname: TRIPATHI, PRAVEEN KUMAR organization: Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India – sequence: 2 givenname: RAMESH CHANDER surname: MAHAJAN fullname: MAHAJAN, RAMESH CHANDER organization: Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India – sequence: 3 givenname: NANCY surname: MALLA fullname: MALLA, NANCY organization: Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India – sequence: 4 givenname: ABHISHEK surname: MEWARA fullname: MEWARA, ABHISHEK organization: Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India – sequence: 5 givenname: SHAILJA MISRA surname: BHATTACHARYA fullname: BHATTACHARYA, SHAILJA MISRA organization: Division of Parasitology, Central Drug Research Institute (CDRI), Lucknow, India – sequence: 6 givenname: RANGANATHA KRISHNA surname: SHENOY fullname: SHENOY, RANGANATHA KRISHNA organization: Department of Medicine, Filariasis Chemotherapy Unit, TD Medical College Hospital, Alleppey, Kerala, India – sequence: 7 givenname: RAKESH surname: SEHGAL fullname: SEHGAL, RAKESH email: sehgalpgi@gmail.com organization: Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26646772$$D View this record in MEDLINE/PubMed |
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| Keywords | stage-specific antigenaemia circulating filarial antigen (CFA) pre- and post-treatment kinetics Brugian filariasis |
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| Snippet | Human lymphatic filariasis (LF) is a major cause of disability globally. The success of global elimination programmes for LF depends upon effectiveness of... SUMMARY Human lymphatic filariasis (LF) is a major cause of disability globally. The success of global elimination programmes for LF depends upon effectiveness... SUMMARYHuman lymphatic filariasis (LF) is a major cause of disability globally. The success of global elimination programmes for LF depends upon effectiveness... |
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| SubjectTerms | Adult adults Animals antigen detection Antigens Antigens, Helminth - blood Asymptomatic Diseases blood serum Chronic illnesses Diethylcarbamazine - therapeutic use Drug dosages Edema Elephantiasis, Filarial - drug therapy Elephantiasis, Filarial - immunology Elephantiasis, Filarial - parasitology Elephantiasis, Filarial - physiopathology Fecundity Female Filariasis Humans India Infections Life Cycle Stages - immunology Male Medical education microfilariae Mosquitoes patients Protozoa Rabbits Tropical diseases Vector-borne diseases Wuchereria bancrofti - growth & development Wuchereria bancrofti - immunology Young Adult |
| Title | Circulating filarial antigen detection in brugian filariasis |
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