Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction

Working memory impairments are a core aspect of schizophrenia, yet current medicines do not address such cognitive dysfunction. We have developed a model of these working memory deficits by acutely disrupting glutamatergic synaptic transmission by administration of the N-methyl- d-aspartate (NMDA) a...

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Bibliographic Details
Published inBehavioural brain research Vol. 212; no. 1; pp. 41 - 48
Main Authors Roberts, Brooke M., Holden, Daniel E., Shaffer, Christopher L., Seymour, Patricia A., Menniti, Frank S., Schmidt, Christopher J., Williams, Graham V., Castner, Stacy A.
Format Journal Article
LanguageEnglish
Published Shannon Elsevier B.V 01.09.2010
Elsevier
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