Selection of Payloads for Antibody–Drug Conjugates Targeting Ubiquitously Expressed Tumor-Associated Antigens: a Case Study

• Published in: The AAPS journal Vol. 24; no. 4; p. 70
• Main Authors: Yao, Bing, Gao, Xiao, Dan, Mo, Yuan, Can, Hu, Xixin, Sun, Zhaopeng, Hui, Xiwu, Liu, Boning, Ouyang, Pingkai, Chen, Guoguang
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 27.05.2022; Springer
• Subjects: Antibodies; Antigens; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biopharmaceutics; Biotechnology; Case studies; Drug therapy; Ethylenediaminetetraacetic acid; Health aspects; Pancreatic cancer; Pharmacology/Toxicology; Pharmacy; Research Article; Viral antibodies; DXd; therapeutic window; Trop-2; antibody–drug conjugate

The main objective of this work was to demonstrate which kind of payload is the suitable choice for antibody–drug conjugates directed to widely expressed tumor-associated antigen. Trop-2 is overexpressed in various solid tumors, but it is also present on the epithelium of several normal tissues. A w...