Experimental Determination of the Absorption Rate of Unattached Radon Progeny from Respiratory Tract to Blood
An exposure methodology was developed for the determination of the absorption rate of unattached radon progeny deposited in the human respiratory tract to blood. Twenty-one volunteers were exposed in a radon chamber during well-controlled aerosol and radon progeny conditions, with predominantly unat...
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| Published in | Radiation protection dosimetry Vol. 102; no. 4; pp. 343 - 348 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Oxford University Press
01.01.2002
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| Abstract | An exposure methodology was developed for the determination of the absorption rate of unattached radon progeny deposited in the human respiratory tract to blood. Twenty-one volunteers were exposed in a radon chamber during well-controlled aerosol and radon progeny conditions, with predominantly unattached radon daughters. Special efforts were made to restrict the dose to the volunteers to an absolute maximum of 0.08 mSv. Measurements of radon gas and radon progeny in blood samples of these volunteers indicated absorption half times of 20 min to 60 min. Former determinations, mainly performed with much larger aerosol particles of diameters between 100 nm and 1000 nm, implied absorption half times around 10 h. This indicates that the absorption of radon decay products from ciliated airways into blood is dependent upon particle size and particle composition. |
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| AbstractList | An exposure methodology was developed for the determination of the absorption rate of unattached radon progeny deposited in the human respiratory tract to blood. Twenty-one volunteers were exposed in a radon chamber during well-controlled aerosol and radon progeny conditions, with predominantly unattached radon daughters. Special efforts were made to restrict the dose to the volunteers to an absolute maximum of 0.08 mSv. Measurements of radon gas and radon progeny in blood samples of these volunteers indicated absorption half times of 20 min to 60 min. Former determinations, mainly performed with much larger aerosol particles of diameters between 100 nm and 1,000 nm, implied absorption half times around 10 h. This indicates that the absorption of radon decay products from ciliated airways into blood is dependent upon particle size and particle composition. An exposure methodology was developed for the determination of the absorption rate of unattached radon progeny deposited in the human respiratory tract to blood. Twenty-one volunteers were exposed in a radon chamber during well-controlled aerosol and radon progeny conditions, with predominantly unattached radon daughters. Special efforts were made to restrict the dose to the volunteers to an absolute maximum of 0.08 mSv. Measurements of radon gas and radon progeny in blood samples of these volunteers indicated absorption half times of 20 min to 60 min. Former determinations, mainly performed with much larger aerosol particles of diameters between 100 nm and 1000 nm, implied absorption half times around 10 h. This indicates that the absorption of radon decay products from ciliated airways into blood is dependent upon particle size and particle composition. The design and development of an exposure technique for evaluating the absorption rate to blood of unattached radon progeny deposited in the human respiratory tract. Scientists experimentally exposed 21 subjects with predominantly unattached radon daughters in a radon chamber under well-controlled aerosol and radon progeny conditions. The study was designed to restrict exposure levels in volunteers to a maximum of 0.08 mSv. Data obtained from measurements of radon gas and radon progeny in blood samples of the volunteers showed absorption half times of 20-60 minutes. Findings from previous studies, which typically targeted much larger aerosol particles with diameters between 100-1000 nm, indicated absorption half times of approximately 10 hours. Implications of these findings are discussed. An exposure methodology was developed for the determination of the absorption rate of unattached radon progeny deposited in the human respiratory tract to blood. Twenty-one volunteers were exposed in a radon chamber during well-controlled aerosol and radon progeny conditions, with predominantly unattached radon daughters. Special efforts were made to restrict the dose to the volunteers to an absolute maximum of 0.08 mSv. Measurements of radon gas and radon progeny in blood samples of these volunteers indicated absorption half times of 20 min to 60 min. Former determinations, mainly performed with much larger aerosol particles of diameters between 100 nm and 1,000 nm, implied absorption half times around 10 h. This indicates that the absorption of radon decay products from ciliated airways into blood is dependent upon particle size and particle composition.An exposure methodology was developed for the determination of the absorption rate of unattached radon progeny deposited in the human respiratory tract to blood. Twenty-one volunteers were exposed in a radon chamber during well-controlled aerosol and radon progeny conditions, with predominantly unattached radon daughters. Special efforts were made to restrict the dose to the volunteers to an absolute maximum of 0.08 mSv. Measurements of radon gas and radon progeny in blood samples of these volunteers indicated absorption half times of 20 min to 60 min. Former determinations, mainly performed with much larger aerosol particles of diameters between 100 nm and 1,000 nm, implied absorption half times around 10 h. This indicates that the absorption of radon decay products from ciliated airways into blood is dependent upon particle size and particle composition. |
| Author | Müller, R. Vessù, G. Thrift, S. W. Marsh, J. Butterweck, G. Schuler, Ch Birchall, A. |
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| Snippet | An exposure methodology was developed for the determination of the absorption rate of unattached radon progeny deposited in the human respiratory tract to... The design and development of an exposure technique for evaluating the absorption rate to blood of unattached radon progeny deposited in the human respiratory... |
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| SubjectTerms | Absorption Administration, Inhalation Aerosols Biological and medical sciences Calibration Dose-Response Relationship, Radiation Environmental Monitoring - methods Humans Medical sciences Radiometry - methods Radon - pharmacokinetics Radon Daughters Respiratory System - metabolism Sensitivity and Specificity |
| Title | Experimental Determination of the Absorption Rate of Unattached Radon Progeny from Respiratory Tract to Blood |
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