A Glimpse into Humoral Response and Related Therapeutic Approaches of Takayasu’s Arteritis

• Published in: International journal of molecular sciences Vol. 25; no. 12; p. 6528
• Main Authors: Guo, Shuning, Tian, Yixiao, Li, Jing, Zeng, Xiaofeng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.06.2024; MDPI
• Subjects: Animals; Antibodies; Antigens; Autoantibodies; Autoantibodies - immunology; Autoimmunity; B cells; B-Lymphocytes - immunology; Blood coagulation factors; Cells; Coronary vessels; Development and progression; Disease; Granulomas; Health aspects; Humans; Immunity, Humoral; Immunology; Immunotherapy; Inflammation; Lymphocytes; Monoclonal antibodies; Pathogenesis; Review; Rituximab - therapeutic use; T cells; Takayasu Arteritis - drug therapy; Takayasu Arteritis - immunology; Takayasu Arteritis - therapy; China; India; autoreactive B cell; Takayasu’s arteritis; rituximab; humoral response

Takayasu’s arteritis (TAK) manifests as an insidiously progressive and debilitating form of granulomatous inflammation including the aorta and its major branches. The precise etiology of TAK remains elusive, with current understanding suggesting an autoimmune origin primarily driven by T cells. Nota...